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Network neighborhood for query Sequence : TXNL1_HUMAN

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TXNL1_HUMAN
SwissProt Accessions	O43396	Gene names	TXNL1, TRP32, TXL, TXNL
Domain Architecture
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TXNL1_HUMAN
θ value	1.72687e-168 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	O43396	Gene names	TXNL1, TRP32, TXL, TXNL
Domain Architecture
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

TXNL1_MOUSE
θ value	1.6163e-166 (rank : 2)	NC score	0.999664 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CDN6, O70379, Q3TI92	Gene names	Txnl1, Trp32, Txnl
Domain Architecture	No domain graphic available
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

THIO_HUMAN
θ value	1.058e-16 (rank : 3)	NC score	0.743788 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P10599, Q96KI3	Gene names	TXN, TRDX, TRX, TRX1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP).

THIO_MOUSE
θ value	1.80466e-16 (rank : 4)	NC score	0.754629 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	P10639, Q52KC4, Q9D8R0	Gene names	Txn, Txn1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF).

TXND2_HUMAN
θ value	4.16044e-13 (rank : 5)	NC score	0.358473 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	793	Shared Neighborhood Hits	25
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

TXND2_MOUSE
θ value	2.0648e-12 (rank : 6)	NC score	0.381819 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

TXND8_HUMAN
θ value	1.9326e-10 (rank : 7)	NC score	0.710360 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A555, Q5T934	Gene names	TXNDC8, SPTRX3, TRX6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

TXND8_MOUSE
θ value	3.29651e-10 (rank : 8)	NC score	0.683487 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	41	Shared Neighborhood Hits	25
SwissProt Accessions	Q69AB2, Q78Y03, Q80YE0, Q9CQ96	Gene names	Txndc8, Sptrx3, Trx6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

TXNL2_MOUSE
θ value	1.06045e-08 (rank : 9)	NC score	0.504736 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CQM9, Q9JLZ2	Gene names	Txnl2, Picot
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

TXNL2_HUMAN
θ value	1.80886e-08 (rank : 10)	NC score	0.499606 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

TXND5_HUMAN
θ value	3.19293e-05 (rank : 11)	NC score	0.313109 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9	Gene names	TXNDC5, TLP46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46).

THIOM_MOUSE
θ value	0.000786445 (rank : 12)	NC score	0.440895 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	45	Shared Neighborhood Hits	25
SwissProt Accessions	P97493, Q545D5	Gene names	Txn2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

THIOM_HUMAN
θ value	0.00102713 (rank : 13)	NC score	0.438309 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q99757, Q5JZA0, Q9UH29	Gene names	TXN2, TRX2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

TXND5_MOUSE
θ value	0.00228821 (rank : 14)	NC score	0.305863 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	Q91W90, Q8R1I6	Gene names	Txndc5, Tlp46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46) (Plasma cell- specific thioredoxin-related protein) (PC-TRP).

PDIA3_MOUSE
θ value	0.00390308 (rank : 15)	NC score	0.258079 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	P27773	Gene names	Pdia3, Erp, Erp60, Grp58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57).

PDIA3_HUMAN
θ value	0.00509761 (rank : 16)	NC score	0.250547 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	P30101, Q13453, Q14255, Q8IYF8, Q9UMU7	Gene names	PDIA3, ERP60, GRP58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57) (58 kDa glucose-regulated protein).

TXND3_HUMAN
θ value	0.125558 (rank : 17)	NC score	0.185051 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	70	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N427, Q9NZH1	Gene names	TXNDC3, NME8, SPTRX2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2) (NM23-H8).

ACON_MOUSE
θ value	0.813845 (rank : 18)	NC score	0.063109 (rank : 41)
Query Neighborhood Hits	30	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KI0	Gene names	Aco2
Domain Architecture	No domain graphic available
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

TXND3_MOUSE
θ value	0.813845 (rank : 19)	NC score	0.154228 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q715T0, Q80W74	Gene names	Txndc3, Sptrx2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2).

TXND4_MOUSE
θ value	0.813845 (rank : 20)	NC score	0.201661 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA5_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.204018 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q921X9	Gene names	Pdia5, Pdir
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

ACON_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.056892 (rank : 43)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q99798, O75809	Gene names	ACO2
Domain Architecture
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

PDIA4_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.206554 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

TXND4_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.190573 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BS26, O60319, Q5VWZ7, Q6UW14, Q8WX67	Gene names	TXNDC4, ERP44, KIAA0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA2_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.185443 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q13087, Q96KJ6, Q9BW95	Gene names	PDIA2, PDIP
Domain Architecture
Description	Protein disulfide-isomerase A2 precursor (EC 5.3.4.1) (PDIp).

CTNS_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.021979 (rank : 46)
Query Neighborhood Hits	30	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O60931, Q9UNK6	Gene names	CTNS
Domain Architecture
Description	Cystinosin.

IFT52_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.026815 (rank : 45)
Query Neighborhood Hits	30	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y366, Q5H8Z0, Q9H1G3, Q9H1G4, Q9H1H2	Gene names	IFT52, C20orf9, NGD5
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 52 homolog (Protein NGD5 homolog).

PDIA1_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.189613 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	56	Shared Neighborhood Hits	25
SwissProt Accessions	P07237, P30037, P32079, Q15205, Q6LDE5	Gene names	P4HB, PDI, PDIA1, PO4DB
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55).

NOL8_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.016695 (rank : 47)
Query Neighborhood Hits	30	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.

PDIA4_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.194985 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	P13667	Gene names	PDIA4, ERP70, ERP72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

CF010_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.064673 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	329	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SRN2, Q5SPI9, Q5SPJ0, Q5SPK9, Q5SPL0, Q5SRN3, Q5TG25, Q5TG26, Q8N4B6	Gene names	C6orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf10.

GLRX5_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.106663 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SX6, Q3YML0, Q86WY3, Q8IZ54	Gene names	GLRX5, C14orf87
Domain Architecture	No domain graphic available
Description	Glutaredoxin-related protein 5.

GLRX5_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.106499 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q80Y14, Q3YML1, Q9D6E9	Gene names	Glrx5
Domain Architecture	No domain graphic available
Description	Glutaredoxin-related protein 5.

PDIA1_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.188271 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	22
SwissProt Accessions	P09103	Gene names	P4hb, Pdia1
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55) (Erp59).

PDIA5_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.180205 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q14554	Gene names	PDIA5, PDIR
Domain Architecture
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

PDIA6_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.149114 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q15084, Q99778	Gene names	PDIA6, TXNDC7
Domain Architecture
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7).

PDIA6_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.149770 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	Q922R8, Q8BK54	Gene names	Pdia6, Txndc7
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 7).

QSC6L_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.063960 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZRP7, Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2	Gene names	QSCN6L1, QSOX2, SOXN
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1) (Neuroblastoma-derived sulfhydryl oxidase).

QSC6L_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.059966 (rank : 42)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2	Gene names	Qscn6l1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1).

QSCN6_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.063270 (rank : 40)
Query Neighborhood Hits	30	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

QSCN6_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.063390 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BND5, Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6	Gene names	Qscn6, Sox
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) (mSOx).

TXD10_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.128556 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	Q96JJ7, Q8N5J0, Q9NWJ9	Gene names	TXNDC10, KIAA1830, TMX3
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3).

TXD10_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.130310 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXZ1, Q3US84, Q6PGA1, Q6ZPH5, Q8BZB8	Gene names	Txndc10, Kiaa1830
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10).

TXND1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.096647 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H3N1, Q8N487, Q8NBN5, Q9Y4T6	Gene names	TXNDC1, TMX, TXNDC
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor (Transmembrane Trx- related protein) (Thioredoxin-related transmembrane protein).

TXND1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.077134 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VBT0, Q3UCI8, Q9CSD5	Gene names	Txndc1, Txndc
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor.

TXND6_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.162023 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XW9, Q7Z4A8, Q8N1V7	Gene names	TXNDC6, TXL2
Domain Architecture
Description	Thioredoxin domain-containing protein 6 (Thioredoxin-like protein 2) (Txl-2).

TXND9_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.051531 (rank : 44)
Query Neighborhood Hits	30	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	O14530, Q53RV8, Q6NSF5, Q9BRU6	Gene names	TXNDC9, APACD
Domain Architecture
Description	Thioredoxin domain-containing protein 9 (Protein 1-4) (ATP-binding protein associated with cell differentiation).

Hits sorted by NC score

TXNL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.72687e-168 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	O43396	Gene names	TXNL1, TRP32, TXL, TXNL
Domain Architecture
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

TXNL1_MOUSE
NC score	0.999664 (rank : 2)	θ value	1.6163e-166 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CDN6, O70379, Q3TI92	Gene names	Txnl1, Trp32, Txnl
Domain Architecture	No domain graphic available
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

THIO_MOUSE
NC score	0.754629 (rank : 3)	θ value	1.80466e-16 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	P10639, Q52KC4, Q9D8R0	Gene names	Txn, Txn1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF).

THIO_HUMAN
NC score	0.743788 (rank : 4)	θ value	1.058e-16 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P10599, Q96KI3	Gene names	TXN, TRDX, TRX, TRX1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP).

TXND8_HUMAN
NC score	0.710360 (rank : 5)	θ value	1.9326e-10 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A555, Q5T934	Gene names	TXNDC8, SPTRX3, TRX6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

TXND8_MOUSE
NC score	0.683487 (rank : 6)	θ value	3.29651e-10 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	41	Shared Neighborhood Hits	25
SwissProt Accessions	Q69AB2, Q78Y03, Q80YE0, Q9CQ96	Gene names	Txndc8, Sptrx3, Trx6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

TXNL2_MOUSE
NC score	0.504736 (rank : 7)	θ value	1.06045e-08 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CQM9, Q9JLZ2	Gene names	Txnl2, Picot
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

TXNL2_HUMAN
NC score	0.499606 (rank : 8)	θ value	1.80886e-08 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

THIOM_MOUSE
NC score	0.440895 (rank : 9)	θ value	0.000786445 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	45	Shared Neighborhood Hits	25
SwissProt Accessions	P97493, Q545D5	Gene names	Txn2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

THIOM_HUMAN
NC score	0.438309 (rank : 10)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q99757, Q5JZA0, Q9UH29	Gene names	TXN2, TRX2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

TXND2_MOUSE
NC score	0.381819 (rank : 11)	θ value	2.0648e-12 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

TXND2_HUMAN
NC score	0.358473 (rank : 12)	θ value	4.16044e-13 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	793	Shared Neighborhood Hits	25
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

TXND5_HUMAN
NC score	0.313109 (rank : 13)	θ value	3.19293e-05 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9	Gene names	TXNDC5, TLP46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46).

TXND5_MOUSE
NC score	0.305863 (rank : 14)	θ value	0.00228821 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	Q91W90, Q8R1I6	Gene names	Txndc5, Tlp46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46) (Plasma cell- specific thioredoxin-related protein) (PC-TRP).

PDIA3_MOUSE
NC score	0.258079 (rank : 15)	θ value	0.00390308 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	P27773	Gene names	Pdia3, Erp, Erp60, Grp58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57).

PDIA3_HUMAN
NC score	0.250547 (rank : 16)	θ value	0.00509761 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	P30101, Q13453, Q14255, Q8IYF8, Q9UMU7	Gene names	PDIA3, ERP60, GRP58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57) (58 kDa glucose-regulated protein).

PDIA4_MOUSE
NC score	0.206554 (rank : 17)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

PDIA5_MOUSE
NC score	0.204018 (rank : 18)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q921X9	Gene names	Pdia5, Pdir
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

TXND4_MOUSE
NC score	0.201661 (rank : 19)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA4_HUMAN
NC score	0.194985 (rank : 20)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	P13667	Gene names	PDIA4, ERP70, ERP72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

TXND4_HUMAN
NC score	0.190573 (rank : 21)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BS26, O60319, Q5VWZ7, Q6UW14, Q8WX67	Gene names	TXNDC4, ERP44, KIAA0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA1_HUMAN
NC score	0.189613 (rank : 22)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	56	Shared Neighborhood Hits	25
SwissProt Accessions	P07237, P30037, P32079, Q15205, Q6LDE5	Gene names	P4HB, PDI, PDIA1, PO4DB
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55).

PDIA1_MOUSE
NC score	0.188271 (rank : 23)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	22
SwissProt Accessions	P09103	Gene names	P4hb, Pdia1
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55) (Erp59).

PDIA2_HUMAN
NC score	0.185443 (rank : 24)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q13087, Q96KJ6, Q9BW95	Gene names	PDIA2, PDIP
Domain Architecture
Description	Protein disulfide-isomerase A2 precursor (EC 5.3.4.1) (PDIp).

TXND3_HUMAN
NC score	0.185051 (rank : 25)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	70	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N427, Q9NZH1	Gene names	TXNDC3, NME8, SPTRX2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2) (NM23-H8).

PDIA5_HUMAN
NC score	0.180205 (rank : 26)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q14554	Gene names	PDIA5, PDIR
Domain Architecture
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

TXND6_HUMAN
NC score	0.162023 (rank : 27)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XW9, Q7Z4A8, Q8N1V7	Gene names	TXNDC6, TXL2
Domain Architecture
Description	Thioredoxin domain-containing protein 6 (Thioredoxin-like protein 2) (Txl-2).

TXND3_MOUSE
NC score	0.154228 (rank : 28)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q715T0, Q80W74	Gene names	Txndc3, Sptrx2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2).

PDIA6_MOUSE
NC score	0.149770 (rank : 29)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	Q922R8, Q8BK54	Gene names	Pdia6, Txndc7
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 7).

PDIA6_HUMAN
NC score	0.149114 (rank : 30)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q15084, Q99778	Gene names	PDIA6, TXNDC7
Domain Architecture
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7).

TXD10_MOUSE
NC score	0.130310 (rank : 31)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	30	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXZ1, Q3US84, Q6PGA1, Q6ZPH5, Q8BZB8	Gene names	Txndc10, Kiaa1830
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10).

TXD10_HUMAN
NC score	0.128556 (rank : 32)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	Q96JJ7, Q8N5J0, Q9NWJ9	Gene names	TXNDC10, KIAA1830, TMX3
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3).

GLRX5_HUMAN
NC score	0.106663 (rank : 33)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SX6, Q3YML0, Q86WY3, Q8IZ54	Gene names	GLRX5, C14orf87
Domain Architecture	No domain graphic available
Description	Glutaredoxin-related protein 5.

GLRX5_MOUSE
NC score	0.106499 (rank : 34)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q80Y14, Q3YML1, Q9D6E9	Gene names	Glrx5
Domain Architecture	No domain graphic available
Description	Glutaredoxin-related protein 5.

TXND1_HUMAN
NC score	0.096647 (rank : 35)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H3N1, Q8N487, Q8NBN5, Q9Y4T6	Gene names	TXNDC1, TMX, TXNDC
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor (Transmembrane Trx- related protein) (Thioredoxin-related transmembrane protein).

TXND1_MOUSE
NC score	0.077134 (rank : 36)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VBT0, Q3UCI8, Q9CSD5	Gene names	Txndc1, Txndc
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor.

CF010_HUMAN
NC score	0.064673 (rank : 37)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	329	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SRN2, Q5SPI9, Q5SPJ0, Q5SPK9, Q5SPL0, Q5SRN3, Q5TG25, Q5TG26, Q8N4B6	Gene names	C6orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf10.

QSC6L_HUMAN
NC score	0.063960 (rank : 38)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZRP7, Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2	Gene names	QSCN6L1, QSOX2, SOXN
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1) (Neuroblastoma-derived sulfhydryl oxidase).

QSCN6_MOUSE
NC score	0.063390 (rank : 39)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	30	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BND5, Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6	Gene names	Qscn6, Sox
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) (mSOx).

QSCN6_HUMAN
NC score	0.063270 (rank : 40)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	30	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

ACON_MOUSE
NC score	0.063109 (rank : 41)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KI0	Gene names	Aco2
Domain Architecture	No domain graphic available
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

QSC6L_MOUSE
NC score	0.059966 (rank : 42)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2	Gene names	Qscn6l1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1).

ACON_HUMAN
NC score	0.056892 (rank : 43)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q99798, O75809	Gene names	ACO2
Domain Architecture
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

TXND9_HUMAN
NC score	0.051531 (rank : 44)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	30	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	O14530, Q53RV8, Q6NSF5, Q9BRU6	Gene names	TXNDC9, APACD
Domain Architecture
Description	Thioredoxin domain-containing protein 9 (Protein 1-4) (ATP-binding protein associated with cell differentiation).

IFT52_HUMAN
NC score	0.026815 (rank : 45)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y366, Q5H8Z0, Q9H1G3, Q9H1G4, Q9H1H2	Gene names	IFT52, C20orf9, NGD5
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 52 homolog (Protein NGD5 homolog).

CTNS_HUMAN
NC score	0.021979 (rank : 46)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O60931, Q9UNK6	Gene names	CTNS
Domain Architecture
Description	Cystinosin.

NOL8_MOUSE
NC score	0.016695 (rank : 47)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.