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Network neighborhood for query Sequence : ACON_HUMAN

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ACON_HUMAN
SwissProt Accessions	Q99798, O75809	Gene names	ACO2
Domain Architecture
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ACON_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q99798, O75809	Gene names	ACO2
Domain Architecture
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

ACON_MOUSE
θ value	0 (rank : 2)	NC score	0.999510 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q99KI0	Gene names	Aco2
Domain Architecture	No domain graphic available
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB1_MOUSE
θ value	7.25919e-50 (rank : 3)	NC score	0.793923 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P28271, Q99K54	Gene names	Aco1, Ireb1, Irebp
Domain Architecture
Description	Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB1_HUMAN
θ value	6.14528e-49 (rank : 4)	NC score	0.793021 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P21399, Q14652	Gene names	ACO1, IREB1
Domain Architecture
Description	Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB2_MOUSE
θ value	2.58786e-39 (rank : 5)	NC score	0.769720 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q811J3, O70235	Gene names	Ireb2, Irp2
Domain Architecture	No domain graphic available
Description	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2).

IREB2_HUMAN
θ value	4.88048e-38 (rank : 6)	NC score	0.765874 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P48200, Q13095	Gene names	IREB2
Domain Architecture
Description	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2).

TXNL1_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.056892 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	O43396	Gene names	TXNL1, TRP32, TXL, TXNL
Domain Architecture
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

TXNL1_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.056967 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDN6, O70379, Q3TI92	Gene names	Txnl1, Trp32, Txnl
Domain Architecture	No domain graphic available
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

SNX21_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.041577 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q969T3, Q5JZH6, Q9BR16	Gene names	SNX21, C20orf161, SNXL
Domain Architecture
Description	Sorting nexin-21 (Sorting nexin L) (SNX-L).

PHOS_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.037190 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QW08	Gene names	Pdc, Rpr1
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (Rod photoreceptor 1) (RPR-1).

PUM2_MOUSE
θ value	5.27518 (rank : 11)	NC score	0.016167 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7	Gene names	Pum2, Kiaa0235
Domain Architecture
Description	Pumilio homolog 2.

GRIP1_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.006992 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	241	Shared Neighborhood Hits	2
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

ZFHX2_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.004460 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	1178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

BCAR1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.006319 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	438	Shared Neighborhood Hits	2
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

K0460_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.013843 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

PUM2_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.014242 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

Hits sorted by NC score

ACON_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q99798, O75809	Gene names	ACO2
Domain Architecture
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

ACON_MOUSE
NC score	0.999510 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q99KI0	Gene names	Aco2
Domain Architecture	No domain graphic available
Description	Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB1_MOUSE
NC score	0.793923 (rank : 3)	θ value	7.25919e-50 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P28271, Q99K54	Gene names	Aco1, Ireb1, Irebp
Domain Architecture
Description	Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB1_HUMAN
NC score	0.793021 (rank : 4)	θ value	6.14528e-49 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P21399, Q14652	Gene names	ACO1, IREB1
Domain Architecture
Description	Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

IREB2_MOUSE
NC score	0.769720 (rank : 5)	θ value	2.58786e-39 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q811J3, O70235	Gene names	Ireb2, Irp2
Domain Architecture	No domain graphic available
Description	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2).

IREB2_HUMAN
NC score	0.765874 (rank : 6)	θ value	4.88048e-38 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P48200, Q13095	Gene names	IREB2
Domain Architecture
Description	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2).

TXNL1_MOUSE
NC score	0.056967 (rank : 7)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDN6, O70379, Q3TI92	Gene names	Txnl1, Trp32, Txnl
Domain Architecture	No domain graphic available
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

TXNL1_HUMAN
NC score	0.056892 (rank : 8)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	O43396	Gene names	TXNL1, TRP32, TXL, TXNL
Domain Architecture
Description	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein).

SNX21_HUMAN
NC score	0.041577 (rank : 9)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q969T3, Q5JZH6, Q9BR16	Gene names	SNX21, C20orf161, SNXL
Domain Architecture
Description	Sorting nexin-21 (Sorting nexin L) (SNX-L).

PHOS_MOUSE
NC score	0.037190 (rank : 10)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QW08	Gene names	Pdc, Rpr1
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (Rod photoreceptor 1) (RPR-1).

PUM2_MOUSE
NC score	0.016167 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7	Gene names	Pum2, Kiaa0235
Domain Architecture
Description	Pumilio homolog 2.

PUM2_HUMAN
NC score	0.014242 (rank : 12)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

K0460_HUMAN
NC score	0.013843 (rank : 13)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

GRIP1_MOUSE
NC score	0.006992 (rank : 14)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	241	Shared Neighborhood Hits	2
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

BCAR1_MOUSE
NC score	0.006319 (rank : 15)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	438	Shared Neighborhood Hits	2
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ZFHX2_HUMAN
NC score	0.004460 (rank : 16)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	1178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.