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Network neighborhood for query Sequence : NSF_HUMAN

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NSF_HUMAN
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NSF_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

NSF_MOUSE
θ value	0 (rank : 2)	NC score	0.999700 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

TERA_HUMAN
θ value	1.28137e-46 (rank : 3)	NC score	0.933130 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	66
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
θ value	1.67352e-46 (rank : 4)	NC score	0.933070 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	66
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

PRS8_HUMAN
θ value	2.05049e-36 (rank : 5)	NC score	0.926538 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
θ value	2.05049e-36 (rank : 6)	NC score	0.926538 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PEX1_HUMAN
θ value	2.96089e-35 (rank : 7)	NC score	0.924029 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

NVL_HUMAN
θ value	3.86705e-35 (rank : 8)	NC score	0.916468 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	112	Shared Neighborhood Hits	65
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_MOUSE
θ value	5.584e-34 (rank : 9)	NC score	0.916938 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	110	Shared Neighborhood Hits	64
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

PRS4_HUMAN
θ value	5.584e-34 (rank : 10)	NC score	0.924363 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
θ value	5.584e-34 (rank : 11)	NC score	0.924363 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS10_HUMAN
θ value	9.52487e-34 (rank : 12)	NC score	0.924971 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
θ value	9.52487e-34 (rank : 13)	NC score	0.924971 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

ATAD2_MOUSE
θ value	1.98606e-31 (rank : 14)	NC score	0.864963 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

PEX6_MOUSE
θ value	1.98606e-31 (rank : 15)	NC score	0.909686 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PRS6A_HUMAN
θ value	3.3877e-31 (rank : 16)	NC score	0.918997 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6A_MOUSE
θ value	4.42448e-31 (rank : 17)	NC score	0.919118 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

ATAD2_HUMAN
θ value	2.19584e-30 (rank : 18)	NC score	0.847277 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	322	Shared Neighborhood Hits	58
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

PRS6B_MOUSE
θ value	2.19584e-30 (rank : 19)	NC score	0.918769 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

PEX6_HUMAN
θ value	2.86786e-30 (rank : 20)	NC score	0.908766 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	65
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PRS6B_HUMAN
θ value	8.3442e-30 (rank : 21)	NC score	0.918163 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

AFG31_MOUSE
θ value	5.40856e-29 (rank : 22)	NC score	0.903067 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

PRS7_HUMAN
θ value	7.06379e-29 (rank : 23)	NC score	0.920244 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	61
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
θ value	7.06379e-29 (rank : 24)	NC score	0.920235 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	61
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

AFG32_HUMAN
θ value	9.2256e-29 (rank : 25)	NC score	0.898679 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
θ value	1.57365e-28 (rank : 26)	NC score	0.898248 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

KATL1_MOUSE
θ value	3.62785e-25 (rank : 27)	NC score	0.884752 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_HUMAN
θ value	4.73814e-25 (rank : 28)	NC score	0.884697 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

YMEL1_HUMAN
θ value	2.35151e-24 (rank : 29)	NC score	0.890614 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	59
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

SPG7_HUMAN
θ value	3.07116e-24 (rank : 30)	NC score	0.897765 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

YMEL1_MOUSE
θ value	4.01107e-24 (rank : 31)	NC score	0.892871 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

KTNA1_HUMAN
θ value	5.79196e-23 (rank : 32)	NC score	0.879257 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	64
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

KTNA1_MOUSE
θ value	3.75424e-22 (rank : 33)	NC score	0.876233 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

VPS4A_HUMAN
θ value	1.33526e-19 (rank : 34)	NC score	0.862238 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
θ value	1.33526e-19 (rank : 35)	NC score	0.862230 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

SPAST_HUMAN
θ value	2.27762e-19 (rank : 36)	NC score	0.868029 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
θ value	2.27762e-19 (rank : 37)	NC score	0.866928 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

VPS4B_MOUSE
θ value	4.29542e-18 (rank : 38)	NC score	0.861197 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_HUMAN
θ value	5.60996e-18 (rank : 39)	NC score	0.861575 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

ATAD1_HUMAN
θ value	1.63225e-17 (rank : 40)	NC score	0.886797 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
θ value	1.63225e-17 (rank : 41)	NC score	0.886797 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

TRP13_HUMAN
θ value	7.34386e-10 (rank : 42)	NC score	0.717165 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

FIGN_MOUSE
θ value	2.79066e-09 (rank : 43)	NC score	0.802212 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

TRP13_MOUSE
θ value	2.79066e-09 (rank : 44)	NC score	0.717898 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

FIGN_HUMAN
θ value	1.06045e-08 (rank : 45)	NC score	0.795910 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

ATD3B_HUMAN
θ value	8.97725e-08 (rank : 46)	NC score	0.602335 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	340	Shared Neighborhood Hits	60
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

BCS1_HUMAN
θ value	1.29631e-06 (rank : 47)	NC score	0.679993 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

ATD3A_HUMAN
θ value	2.21117e-06 (rank : 48)	NC score	0.608436 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

BCS1_MOUSE
θ value	4.92598e-06 (rank : 49)	NC score	0.668576 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

ATAD3_MOUSE
θ value	2.44474e-05 (rank : 50)	NC score	0.586287 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	326	Shared Neighborhood Hits	61
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

CLPX_MOUSE
θ value	0.00102713 (rank : 51)	NC score	0.437986 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_HUMAN
θ value	0.00134147 (rank : 52)	NC score	0.438924 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

THNSL_HUMAN
θ value	0.365318 (rank : 53)	NC score	0.118932 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

LONM_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.407836 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

RUVB1_HUMAN
θ value	0.62314 (rank : 55)	NC score	0.299944 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
θ value	0.62314 (rank : 56)	NC score	0.299908 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

WRIP1_HUMAN
θ value	1.81305 (rank : 57)	NC score	0.224279 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	52
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WRIP1_MOUSE
θ value	1.81305 (rank : 58)	NC score	0.227343 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

BCAR3_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.011737 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

RFC5_MOUSE
θ value	3.0926 (rank : 60)	NC score	0.074243 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.072181 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

GIT2_HUMAN
θ value	5.27518 (rank : 62)	NC score	0.002211 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	381	Shared Neighborhood Hits	2
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

RAD17_MOUSE
θ value	5.27518 (rank : 63)	NC score	0.055055 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	Q6NXW6, O88934, O89024	Gene names	Rad17
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint protein RAD17.

RFC1_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.106326 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	352	Shared Neighborhood Hits	44
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC1_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.119480 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	290	Shared Neighborhood Hits	46
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

GP128_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.002828 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BM96, Q80T42	Gene names	Gpr128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

KAD6_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.098372 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

SCN2A_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.002527 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

THNSL_MOUSE
θ value	6.88961 (rank : 69)	NC score	0.111798 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

ABCD3_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.004340 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P28288, Q15271, Q9H529	Gene names	ABCD3, PMP70, PXMP1
Domain Architecture
Description	ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal membrane protein) (PMP70).

EP400_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.003788 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	556	Shared Neighborhood Hits	4
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

RUVB2_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.114417 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.112060 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

YSK4_HUMAN
θ value	8.99809 (rank : 74)	NC score	-0.006016 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	921	Shared Neighborhood Hits	2
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

KAD6_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.074298 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC4_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.097151 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

RFC4_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.086133 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

Hits sorted by NC score

NSF_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

NSF_MOUSE
NC score	0.999700 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

TERA_HUMAN
NC score	0.933130 (rank : 3)	θ value	1.28137e-46 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	66
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
NC score	0.933070 (rank : 4)	θ value	1.67352e-46 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	66
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

PRS8_HUMAN
NC score	0.926538 (rank : 5)	θ value	2.05049e-36 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
NC score	0.926538 (rank : 6)	θ value	2.05049e-36 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS10_HUMAN
NC score	0.924971 (rank : 7)	θ value	9.52487e-34 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
NC score	0.924971 (rank : 8)	θ value	9.52487e-34 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS4_HUMAN
NC score	0.924363 (rank : 9)	θ value	5.584e-34 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
NC score	0.924363 (rank : 10)	θ value	5.584e-34 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PEX1_HUMAN
NC score	0.924029 (rank : 11)	θ value	2.96089e-35 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

PRS7_HUMAN
NC score	0.920244 (rank : 12)	θ value	7.06379e-29 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	61
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
NC score	0.920235 (rank : 13)	θ value	7.06379e-29 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	61
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS6A_MOUSE
NC score	0.919118 (rank : 14)	θ value	4.42448e-31 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6A_HUMAN
NC score	0.918997 (rank : 15)	θ value	3.3877e-31 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6B_MOUSE
NC score	0.918769 (rank : 16)	θ value	2.19584e-30 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

PRS6B_HUMAN
NC score	0.918163 (rank : 17)	θ value	8.3442e-30 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

NVL_MOUSE
NC score	0.916938 (rank : 18)	θ value	5.584e-34 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	110	Shared Neighborhood Hits	64
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_HUMAN
NC score	0.916468 (rank : 19)	θ value	3.86705e-35 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	112	Shared Neighborhood Hits	65
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

PEX6_MOUSE
NC score	0.909686 (rank : 20)	θ value	1.98606e-31 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_HUMAN
NC score	0.908766 (rank : 21)	θ value	2.86786e-30 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	65
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

AFG31_MOUSE
NC score	0.903067 (rank : 22)	θ value	5.40856e-29 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

AFG32_HUMAN
NC score	0.898679 (rank : 23)	θ value	9.2256e-29 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
NC score	0.898248 (rank : 24)	θ value	1.57365e-28 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

SPG7_HUMAN
NC score	0.897765 (rank : 25)	θ value	3.07116e-24 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

YMEL1_MOUSE
NC score	0.892871 (rank : 26)	θ value	4.01107e-24 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

YMEL1_HUMAN
NC score	0.890614 (rank : 27)	θ value	2.35151e-24 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	59
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

ATAD1_HUMAN
NC score	0.886797 (rank : 28)	θ value	1.63225e-17 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
NC score	0.886797 (rank : 29)	θ value	1.63225e-17 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

KATL1_MOUSE
NC score	0.884752 (rank : 30)	θ value	3.62785e-25 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_HUMAN
NC score	0.884697 (rank : 31)	θ value	4.73814e-25 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KTNA1_HUMAN
NC score	0.879257 (rank : 32)	θ value	5.79196e-23 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	64
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

KTNA1_MOUSE
NC score	0.876233 (rank : 33)	θ value	3.75424e-22 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

SPAST_HUMAN
NC score	0.868029 (rank : 34)	θ value	2.27762e-19 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
NC score	0.866928 (rank : 35)	θ value	2.27762e-19 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

ATAD2_MOUSE
NC score	0.864963 (rank : 36)	θ value	1.98606e-31 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

VPS4A_HUMAN
NC score	0.862238 (rank : 37)	θ value	1.33526e-19 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
NC score	0.862230 (rank : 38)	θ value	1.33526e-19 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

VPS4B_HUMAN
NC score	0.861575 (rank : 39)	θ value	5.60996e-18 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_MOUSE
NC score	0.861197 (rank : 40)	θ value	4.29542e-18 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

ATAD2_HUMAN
NC score	0.847277 (rank : 41)	θ value	2.19584e-30 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	322	Shared Neighborhood Hits	58
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FIGN_MOUSE
NC score	0.802212 (rank : 42)	θ value	2.79066e-09 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_HUMAN
NC score	0.795910 (rank : 43)	θ value	1.06045e-08 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

TRP13_MOUSE
NC score	0.717898 (rank : 44)	θ value	2.79066e-09 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

TRP13_HUMAN
NC score	0.717165 (rank : 45)	θ value	7.34386e-10 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

BCS1_HUMAN
NC score	0.679993 (rank : 46)	θ value	1.29631e-06 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

BCS1_MOUSE
NC score	0.668576 (rank : 47)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

ATD3A_HUMAN
NC score	0.608436 (rank : 48)	θ value	2.21117e-06 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
NC score	0.602335 (rank : 49)	θ value	8.97725e-08 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	340	Shared Neighborhood Hits	60
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

ATAD3_MOUSE
NC score	0.586287 (rank : 50)	θ value	2.44474e-05 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	326	Shared Neighborhood Hits	61
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

CLPX_HUMAN
NC score	0.438924 (rank : 51)	θ value	0.00134147 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
NC score	0.437986 (rank : 52)	θ value	0.00102713 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

LONM_HUMAN
NC score	0.407836 (rank : 53)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

RUVB1_HUMAN
NC score	0.299944 (rank : 54)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
NC score	0.299908 (rank : 55)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

WRIP1_MOUSE
NC score	0.227343 (rank : 56)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WRIP1_HUMAN
NC score	0.224279 (rank : 57)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	52
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

RFC1_MOUSE
NC score	0.119480 (rank : 58)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	290	Shared Neighborhood Hits	46
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

THNSL_HUMAN
NC score	0.118932 (rank : 59)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RUVB2_HUMAN
NC score	0.114417 (rank : 60)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
NC score	0.112060 (rank : 61)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

THNSL_MOUSE
NC score	0.111798 (rank : 62)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RFC1_HUMAN
NC score	0.106326 (rank : 63)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	352	Shared Neighborhood Hits	44
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

KAD6_HUMAN
NC score	0.098372 (rank : 64)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC4_HUMAN
NC score	0.097151 (rank : 65)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

RFC4_MOUSE
NC score	0.086133 (rank : 66)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

KAD6_MOUSE
NC score	0.074298 (rank : 67)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC5_MOUSE
NC score	0.074243 (rank : 68)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_HUMAN
NC score	0.072181 (rank : 69)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RAD17_MOUSE
NC score	0.055055 (rank : 70)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	Q6NXW6, O88934, O89024	Gene names	Rad17
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint protein RAD17.

BCAR3_HUMAN
NC score	0.011737 (rank : 71)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

ABCD3_HUMAN
NC score	0.004340 (rank : 72)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P28288, Q15271, Q9H529	Gene names	ABCD3, PMP70, PXMP1
Domain Architecture
Description	ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal membrane protein) (PMP70).

EP400_HUMAN
NC score	0.003788 (rank : 73)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	556	Shared Neighborhood Hits	4
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

GP128_MOUSE
NC score	0.002828 (rank : 74)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BM96, Q80T42	Gene names	Gpr128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

SCN2A_HUMAN
NC score	0.002527 (rank : 75)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

GIT2_HUMAN
NC score	0.002211 (rank : 76)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	381	Shared Neighborhood Hits	2
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

YSK4_HUMAN
NC score	-0.006016 (rank : 77)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	921	Shared Neighborhood Hits	2
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).