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Network neighborhood for query Sequence : MCM3_HUMAN

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MCM3_HUMAN
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MCM3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MCM3_MOUSE
θ value	0 (rank : 2)	NC score	0.991129 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	95	Shared Neighborhood Hits	49
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MCM2_HUMAN
θ value	3.68522e-86 (rank : 3)	NC score	0.942035 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	P49736, Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7	Gene names	MCM2, BM28, CDCL1, KIAA0030
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM2_MOUSE
θ value	4.07447e-85 (rank : 4)	NC score	0.941542 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	33	Shared Neighborhood Hits	16
SwissProt Accessions	P97310, O08971, O89057, Q8C2R0	Gene names	Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM7_HUMAN
θ value	1.18549e-84 (rank : 5)	NC score	0.945719 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P33993, Q15076, Q96D34, Q96GL1	Gene names	MCM7, CDC47, MCM2
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog) (P1.1-MCM3).

MCM7_MOUSE
θ value	1.89267e-82 (rank : 6)	NC score	0.944861 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61881	Gene names	Mcm7, Cdc47, Mcmd7
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog).

MCM6_MOUSE
θ value	7.19216e-82 (rank : 7)	NC score	0.939530 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

MCM4_MOUSE
θ value	1.2268e-81 (rank : 8)	NC score	0.935933 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM6_HUMAN
θ value	1.77149e-80 (rank : 9)	NC score	0.938790 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q14566, Q13504, Q99859	Gene names	MCM6
Domain Architecture
Description	DNA replication licensing factor MCM6 (p105MCM).

MCM5_HUMAN
θ value	6.30065e-78 (rank : 10)	NC score	0.938259 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	37	Shared Neighborhood Hits	14
SwissProt Accessions	P33992, O60785, Q14578, Q9BTJ4, Q9BWL8	Gene names	MCM5, CDC46
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM5_MOUSE
θ value	1.07473e-77 (rank : 11)	NC score	0.937544 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM4_HUMAN
θ value	9.0981e-77 (rank : 12)	NC score	0.934009 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM8_HUMAN
θ value	2.94036e-59 (rank : 13)	NC score	0.916385 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_MOUSE
θ value	1.11734e-58 (rank : 14)	NC score	0.916333 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MY18A_HUMAN
θ value	0.0148317 (rank : 15)	NC score	0.025103 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	1929	Shared Neighborhood Hits	39
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	0.0148317 (rank : 16)	NC score	0.025660 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	1989	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CCD46_MOUSE
θ value	0.0431538 (rank : 17)	NC score	0.021116 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	1405	Shared Neighborhood Hits	29
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

TEX14_MOUSE
θ value	0.0431538 (rank : 18)	NC score	0.013901 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	1333	Shared Neighborhood Hits	20
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

IWS1_HUMAN
θ value	0.0736092 (rank : 19)	NC score	0.048281 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	1241	Shared Neighborhood Hits	33
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DPOD3_HUMAN
θ value	0.163984 (rank : 20)	NC score	0.049436 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

XRCC1_MOUSE
θ value	0.163984 (rank : 21)	NC score	0.034925 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

VPS4A_MOUSE
θ value	0.21417 (rank : 22)	NC score	0.026921 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

CCD91_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.026241 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	868	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CC45L_MOUSE
θ value	0.47712 (rank : 24)	NC score	0.051447 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1X9, O70547, Q9QUK1, Q9R212	Gene names	Cdc45l, Cdc45l2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1).

FLIP1_HUMAN
θ value	0.47712 (rank : 25)	NC score	0.016325 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	1405	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

IWS1_MOUSE
θ value	0.62314 (rank : 26)	NC score	0.040419 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	1258	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NEST_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.019400 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	1305	Shared Neighborhood Hits	34
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PPIP1_MOUSE
θ value	0.62314 (rank : 28)	NC score	0.018937 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	377	Shared Neighborhood Hits	15
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SAS10_HUMAN
θ value	0.62314 (rank : 29)	NC score	0.030702 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQZ2, Q6FI82	Gene names	CRLZ1, SAS10
Domain Architecture	No domain graphic available
Description	Something about silencing protein 10 (Disrupter of silencing SAS10) (Charged amino acid-rich leucine zipper 1).

VPS4A_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.024061 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

LIPA1_HUMAN
θ value	0.813845 (rank : 31)	NC score	0.014360 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	1294	Shared Neighborhood Hits	26
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

STK10_MOUSE
θ value	1.06291 (rank : 32)	NC score	0.006189 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	2132	Shared Neighborhood Hits	37
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ANR26_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.012238 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	1614	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

SNUT1_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.039402 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	129	Shared Neighborhood Hits	11
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

CSPG2_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.004627 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	681	Shared Neighborhood Hits	6
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

LEO1_MOUSE
θ value	1.81305 (rank : 36)	NC score	0.024597 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	946	Shared Neighborhood Hits	28
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MDN1_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.034880 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	662	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SDCG8_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.018705 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	886	Shared Neighborhood Hits	23
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SH24A_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.025558 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

ATRX_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.023551 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

NUCB1_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.017928 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	414	Shared Neighborhood Hits	19
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

TCAL5_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.015369 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	806	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ADA30_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.003729 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

BAZ1B_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.026392 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	701	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

C8AP2_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.016656 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	548	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

LAD1_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.016778 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	391	Shared Neighborhood Hits	11
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

VPS4B_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.015711 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

WDHD1_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.010700 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

BAZ1B_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.019663 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	394	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

CC45L_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.034918 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O75419, O60856, Q6UW54, Q9UP68	Gene names	CDC45L, CDC45L2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1) (Cdc45).

GP158_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.015449 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

PAPS1_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.028962 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.028960 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.029026 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.029035 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

SNUT1_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.032328 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

UBP34_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.007780 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZNFX1_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.007721 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	407	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

APC_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.010591 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	603	Shared Neighborhood Hits	18
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

ARMX4_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.014095 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H9R4, Q5H9K8, Q8N8D6	Gene names	ARMCX4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 4.

GAK_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.000329 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

IF2M_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.017276 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

ITSN1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.012782 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	1757	Shared Neighborhood Hits	31
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.011871 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	1669	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

LEO1_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.029206 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	958	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LRCH3_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.003218 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

MATR3_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.012439 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	321	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

MDC1_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.005847 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	1446	Shared Neighborhood Hits	22
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MYH8_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.011408 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	1610	Shared Neighborhood Hits	33
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RBBP6_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.013321 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	1135	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RPC5_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.011497 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZT4, Q8CI35, Q9DBD1	Gene names	Polr3e, Sin
Domain Architecture
Description	DNA-directed RNA polymerases III 80 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 5) (RPC5) (Sex-lethal interactor homolog).

SENP7_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.012760 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SPTN2_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.008256 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	535	Shared Neighborhood Hits	21
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

TOP2A_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.014556 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	135	Shared Neighborhood Hits	17
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TTF1_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.014999 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	277	Shared Neighborhood Hits	11
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

ARNT_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.004519 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

GTF2I_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.009428 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

MYH8_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.011163 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	1600	Shared Neighborhood Hits	32
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PPIP1_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.014028 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	389	Shared Neighborhood Hits	15
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

AL2S4_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.008439 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

DHB4_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.007165 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

EDD1_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.008453 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

LRBA_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.003925 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	196	Shared Neighborhood Hits	5
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

OPTN_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.012769 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	827	Shared Neighborhood Hits	21
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

SYCP1_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.012985 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	1456	Shared Neighborhood Hits	31
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TR150_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.010010 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	313	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TXND2_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.020059 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	828	Shared Neighborhood Hits	29
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

Hits sorted by NC score

MCM3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MCM3_MOUSE
NC score	0.991129 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	95	Shared Neighborhood Hits	49
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MCM7_HUMAN
NC score	0.945719 (rank : 3)	θ value	1.18549e-84 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P33993, Q15076, Q96D34, Q96GL1	Gene names	MCM7, CDC47, MCM2
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog) (P1.1-MCM3).

MCM7_MOUSE
NC score	0.944861 (rank : 4)	θ value	1.89267e-82 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61881	Gene names	Mcm7, Cdc47, Mcmd7
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog).

MCM2_HUMAN
NC score	0.942035 (rank : 5)	θ value	3.68522e-86 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	P49736, Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7	Gene names	MCM2, BM28, CDCL1, KIAA0030
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM2_MOUSE
NC score	0.941542 (rank : 6)	θ value	4.07447e-85 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	33	Shared Neighborhood Hits	16
SwissProt Accessions	P97310, O08971, O89057, Q8C2R0	Gene names	Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM6_MOUSE
NC score	0.939530 (rank : 7)	θ value	7.19216e-82 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

MCM6_HUMAN
NC score	0.938790 (rank : 8)	θ value	1.77149e-80 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q14566, Q13504, Q99859	Gene names	MCM6
Domain Architecture
Description	DNA replication licensing factor MCM6 (p105MCM).

MCM5_HUMAN
NC score	0.938259 (rank : 9)	θ value	6.30065e-78 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	37	Shared Neighborhood Hits	14
SwissProt Accessions	P33992, O60785, Q14578, Q9BTJ4, Q9BWL8	Gene names	MCM5, CDC46
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM5_MOUSE
NC score	0.937544 (rank : 10)	θ value	1.07473e-77 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM4_MOUSE
NC score	0.935933 (rank : 11)	θ value	1.2268e-81 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM4_HUMAN
NC score	0.934009 (rank : 12)	θ value	9.0981e-77 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM8_HUMAN
NC score	0.916385 (rank : 13)	θ value	2.94036e-59 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_MOUSE
NC score	0.916333 (rank : 14)	θ value	1.11734e-58 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

CC45L_MOUSE
NC score	0.051447 (rank : 15)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1X9, O70547, Q9QUK1, Q9R212	Gene names	Cdc45l, Cdc45l2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1).

DPOD3_HUMAN
NC score	0.049436 (rank : 16)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

IWS1_HUMAN
NC score	0.048281 (rank : 17)	θ value	0.0736092 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	1241	Shared Neighborhood Hits	33
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
NC score	0.040419 (rank : 18)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	1258	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SNUT1_HUMAN
NC score	0.039402 (rank : 19)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	129	Shared Neighborhood Hits	11
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

XRCC1_MOUSE
NC score	0.034925 (rank : 20)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

CC45L_HUMAN
NC score	0.034918 (rank : 21)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O75419, O60856, Q6UW54, Q9UP68	Gene names	CDC45L, CDC45L2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1) (Cdc45).

MDN1_HUMAN
NC score	0.034880 (rank : 22)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	662	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SNUT1_MOUSE
NC score	0.032328 (rank : 23)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

SAS10_HUMAN
NC score	0.030702 (rank : 24)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQZ2, Q6FI82	Gene names	CRLZ1, SAS10
Domain Architecture	No domain graphic available
Description	Something about silencing protein 10 (Disrupter of silencing SAS10) (Charged amino acid-rich leucine zipper 1).

LEO1_HUMAN
NC score	0.029206 (rank : 25)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	958	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PAPS2_MOUSE
NC score	0.029035 (rank : 26)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
NC score	0.029026 (rank : 27)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_HUMAN
NC score	0.028962 (rank : 28)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
NC score	0.028960 (rank : 29)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

VPS4A_MOUSE
NC score	0.026921 (rank : 30)	θ value	0.21417 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

BAZ1B_HUMAN
NC score	0.026392 (rank : 31)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	701	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CCD91_HUMAN
NC score	0.026241 (rank : 32)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	868	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

MY18A_MOUSE
NC score	0.025660 (rank : 33)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	1989	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SH24A_HUMAN
NC score	0.025558 (rank : 34)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

MY18A_HUMAN
NC score	0.025103 (rank : 35)	θ value	0.0148317 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	1929	Shared Neighborhood Hits	39
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

LEO1_MOUSE
NC score	0.024597 (rank : 36)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	946	Shared Neighborhood Hits	28
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

VPS4A_HUMAN
NC score	0.024061 (rank : 37)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

ATRX_HUMAN
NC score	0.023551 (rank : 38)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

CCD46_MOUSE
NC score	0.021116 (rank : 39)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	1405	Shared Neighborhood Hits	29
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

TXND2_MOUSE
NC score	0.020059 (rank : 40)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	828	Shared Neighborhood Hits	29
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

BAZ1B_MOUSE
NC score	0.019663 (rank : 41)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	394	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

NEST_HUMAN
NC score	0.019400 (rank : 42)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	1305	Shared Neighborhood Hits	34
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PPIP1_MOUSE
NC score	0.018937 (rank : 43)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	377	Shared Neighborhood Hits	15
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SDCG8_MOUSE
NC score	0.018705 (rank : 44)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	886	Shared Neighborhood Hits	23
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

NUCB1_MOUSE
NC score	0.017928 (rank : 45)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	414	Shared Neighborhood Hits	19
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

IF2M_MOUSE
NC score	0.017276 (rank : 46)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

LAD1_MOUSE
NC score	0.016778 (rank : 47)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	391	Shared Neighborhood Hits	11
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

C8AP2_HUMAN
NC score	0.016656 (rank : 48)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	548	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

FLIP1_HUMAN
NC score	0.016325 (rank : 49)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	1405	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

VPS4B_HUMAN
NC score	0.015711 (rank : 50)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

GP158_HUMAN
NC score	0.015449 (rank : 51)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

TCAL5_HUMAN
NC score	0.015369 (rank : 52)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	806	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TTF1_MOUSE
NC score	0.014999 (rank : 53)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	277	Shared Neighborhood Hits	11
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

TOP2A_HUMAN
NC score	0.014556 (rank : 54)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	135	Shared Neighborhood Hits	17
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

LIPA1_HUMAN
NC score	0.014360 (rank : 55)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	1294	Shared Neighborhood Hits	26
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

ARMX4_HUMAN
NC score	0.014095 (rank : 56)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H9R4, Q5H9K8, Q8N8D6	Gene names	ARMCX4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 4.

PPIP1_HUMAN
NC score	0.014028 (rank : 57)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	389	Shared Neighborhood Hits	15
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

TEX14_MOUSE
NC score	0.013901 (rank : 58)	θ value	0.0431538 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	1333	Shared Neighborhood Hits	20
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

RBBP6_HUMAN
NC score	0.013321 (rank : 59)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	1135	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SYCP1_MOUSE
NC score	0.012985 (rank : 60)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	1456	Shared Neighborhood Hits	31
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

ITSN1_HUMAN
NC score	0.012782 (rank : 61)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	1757	Shared Neighborhood Hits	31
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

OPTN_HUMAN
NC score	0.012769 (rank : 62)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	827	Shared Neighborhood Hits	21
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

SENP7_HUMAN
NC score	0.012760 (rank : 63)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

MATR3_MOUSE
NC score	0.012439 (rank : 64)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	321	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

ANR26_HUMAN
NC score	0.012238 (rank : 65)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	1614	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ITSN1_MOUSE
NC score	0.011871 (rank : 66)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	1669	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RPC5_MOUSE
NC score	0.011497 (rank : 67)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZT4, Q8CI35, Q9DBD1	Gene names	Polr3e, Sin
Domain Architecture
Description	DNA-directed RNA polymerases III 80 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 5) (RPC5) (Sex-lethal interactor homolog).

MYH8_HUMAN
NC score	0.011408 (rank : 68)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	1610	Shared Neighborhood Hits	33
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
NC score	0.011163 (rank : 69)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	1600	Shared Neighborhood Hits	32
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

WDHD1_HUMAN
NC score	0.010700 (rank : 70)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

APC_HUMAN
NC score	0.010591 (rank : 71)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	603	Shared Neighborhood Hits	18
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

TR150_HUMAN
NC score	0.010010 (rank : 72)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	313	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

GTF2I_HUMAN
NC score	0.009428 (rank : 73)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

EDD1_HUMAN
NC score	0.008453 (rank : 74)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

AL2S4_MOUSE
NC score	0.008439 (rank : 75)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

SPTN2_HUMAN
NC score	0.008256 (rank : 76)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	535	Shared Neighborhood Hits	21
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

UBP34_HUMAN
NC score	0.007780 (rank : 77)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZNFX1_MOUSE
NC score	0.007721 (rank : 78)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	407	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

DHB4_HUMAN
NC score	0.007165 (rank : 79)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

STK10_MOUSE
NC score	0.006189 (rank : 80)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	2132	Shared Neighborhood Hits	37
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MDC1_HUMAN
NC score	0.005847 (rank : 81)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	1446	Shared Neighborhood Hits	22
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CSPG2_HUMAN
NC score	0.004627 (rank : 82)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	681	Shared Neighborhood Hits	6
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

ARNT_HUMAN
NC score	0.004519 (rank : 83)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

LRBA_HUMAN
NC score	0.003925 (rank : 84)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	196	Shared Neighborhood Hits	5
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

ADA30_HUMAN
NC score	0.003729 (rank : 85)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

LRCH3_MOUSE
NC score	0.003218 (rank : 86)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

GAK_MOUSE
NC score	0.000329 (rank : 87)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).