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Network neighborhood for query Sequence : KELL_HUMAN

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KELL_HUMAN
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KELL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

ECE2_HUMAN
θ value	3.21347e-98 (rank : 2)	NC score	0.964736 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECE1_HUMAN
θ value	2.38316e-93 (rank : 3)	NC score	0.963729 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
θ value	1.54472e-92 (rank : 4)	NC score	0.963860 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECEL1_HUMAN
θ value	1.45253e-74 (rank : 5)	NC score	0.955766 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
θ value	2.09745e-73 (rank : 6)	NC score	0.955184 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

MMEL1_HUMAN
θ value	3.83135e-67 (rank : 7)	NC score	0.946330 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
θ value	3.83135e-67 (rank : 8)	NC score	0.945681 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_MOUSE
θ value	3.974e-56 (rank : 9)	NC score	0.940037 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

PHEX_MOUSE
θ value	2.57589e-55 (rank : 10)	NC score	0.938727 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

NEP_HUMAN
θ value	4.39379e-55 (rank : 11)	NC score	0.939681 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

PHEX_HUMAN
θ value	8.28633e-54 (rank : 12)	NC score	0.938420 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

ZN549_HUMAN
θ value	3.0926 (rank : 13)	NC score	-0.001343 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	741	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P9A3, Q8NAR4	Gene names	ZNF549
Domain Architecture	No domain graphic available
Description	Zinc finger protein 549.

F8I2_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.016417 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q00558	Gene names	F8a1, F8a
Domain Architecture	No domain graphic available
Description	Factor VIII intron 22 protein (CpG island protein).

KTN1_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.001114 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1197	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

COMD2_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.019950 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q86X83, Q9H3L5, Q9Y5V1	Gene names	COMMD2
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 2.

COMD2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.019987 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BXC6, Q8BJI3	Gene names	Commd2
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 2.

SENP6_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.009942 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

Hits sorted by NC score

KELL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

ECE2_HUMAN
NC score	0.964736 (rank : 2)	θ value	3.21347e-98 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECE1_MOUSE
NC score	0.963860 (rank : 3)	θ value	1.54472e-92 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_HUMAN
NC score	0.963729 (rank : 4)	θ value	2.38316e-93 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECEL1_HUMAN
NC score	0.955766 (rank : 5)	θ value	1.45253e-74 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
NC score	0.955184 (rank : 6)	θ value	2.09745e-73 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

MMEL1_HUMAN
NC score	0.946330 (rank : 7)	θ value	3.83135e-67 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
NC score	0.945681 (rank : 8)	θ value	3.83135e-67 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_MOUSE
NC score	0.940037 (rank : 9)	θ value	3.974e-56 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

NEP_HUMAN
NC score	0.939681 (rank : 10)	θ value	4.39379e-55 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

PHEX_MOUSE
NC score	0.938727 (rank : 11)	θ value	2.57589e-55 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_HUMAN
NC score	0.938420 (rank : 12)	θ value	8.28633e-54 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

COMD2_MOUSE
NC score	0.019987 (rank : 13)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BXC6, Q8BJI3	Gene names	Commd2
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 2.

COMD2_HUMAN
NC score	0.019950 (rank : 14)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q86X83, Q9H3L5, Q9Y5V1	Gene names	COMMD2
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 2.

F8I2_MOUSE
NC score	0.016417 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q00558	Gene names	F8a1, F8a
Domain Architecture	No domain graphic available
Description	Factor VIII intron 22 protein (CpG island protein).

SENP6_HUMAN
NC score	0.009942 (rank : 16)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

KTN1_HUMAN
NC score	0.001114 (rank : 17)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	1197	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

ZN549_HUMAN
NC score	-0.001343 (rank : 18)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	741	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P9A3, Q8NAR4	Gene names	ZNF549
Domain Architecture	No domain graphic available
Description	Zinc finger protein 549.