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Network neighborhood for query Sequence : ECE2_HUMAN

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ECE2_HUMAN
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ECE1_HUMAN
θ value	0 (rank : 1)	NC score	0.993035 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
θ value	0 (rank : 2)	NC score	0.993360 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

MMEL1_HUMAN
θ value	2.18956e-155 (rank : 4)	NC score	0.976648 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
θ value	1.32836e-152 (rank : 5)	NC score	0.975805 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

ECEL1_MOUSE
θ value	6.82227e-149 (rank : 6)	NC score	0.977721 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

ECEL1_HUMAN
θ value	3.7435e-147 (rank : 7)	NC score	0.977856 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

NEP_MOUSE
θ value	3.07662e-133 (rank : 8)	NC score	0.973059 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

NEP_HUMAN
θ value	2.87963e-131 (rank : 9)	NC score	0.973037 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

PHEX_MOUSE
θ value	2.13557e-126 (rank : 10)	NC score	0.970092 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_HUMAN
θ value	1.29561e-123 (rank : 11)	NC score	0.970166 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

KELL_HUMAN
θ value	3.21347e-98 (rank : 12)	NC score	0.964736 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

K0859_HUMAN
θ value	4.45536e-07 (rank : 13)	NC score	0.126787 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6R0, O94940, Q5TGP9, Q5TGQ0, Q8N2P8, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6	Gene names	KIAA0859
Domain Architecture	No domain graphic available
Description	Protein KIAA0859.

K0859_MOUSE
θ value	4.92598e-06 (rank : 14)	NC score	0.121849 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YR5, Q3TFY3, Q69ZX4, Q8BWN2, Q8BX81	Gene names	Kiaa0859
Domain Architecture	No domain graphic available
Description	Protein KIAA0859.

DHX35_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.005798 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H5Z1, Q5THR0, Q9H4H7, Q9H6T6	Gene names	DHX35, C20orf15, DDX35
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX35 (EC 3.6.1.-) (DEAH box protein 35).

TTF1_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.012552 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	277	Shared Neighborhood Hits	2
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

CPVL_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.009434 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3G5, Q6UX20, Q8NBL7, Q96AR7, Q9HB41	Gene names	CPVL, VLP
Domain Architecture
Description	Probable serine carboxypeptidase CPVL precursor (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase- like protein) (VCP-like protein) (HVLP).

CC023_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.007846 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3R3, Q495R1, Q495R3, Q6GMU8	Gene names	C3orf23
Domain Architecture	No domain graphic available
Description	Protein C3orf23.

Hits sorted by NC score

ECE2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECE1_MOUSE
NC score	0.993360 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_HUMAN
NC score	0.993035 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECEL1_HUMAN
NC score	0.977856 (rank : 4)	θ value	3.7435e-147 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
NC score	0.977721 (rank : 5)	θ value	6.82227e-149 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

MMEL1_HUMAN
NC score	0.976648 (rank : 6)	θ value	2.18956e-155 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
NC score	0.975805 (rank : 7)	θ value	1.32836e-152 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_MOUSE
NC score	0.973059 (rank : 8)	θ value	3.07662e-133 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

NEP_HUMAN
NC score	0.973037 (rank : 9)	θ value	2.87963e-131 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

PHEX_HUMAN
NC score	0.970166 (rank : 10)	θ value	1.29561e-123 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
NC score	0.970092 (rank : 11)	θ value	2.13557e-126 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

KELL_HUMAN
NC score	0.964736 (rank : 12)	θ value	3.21347e-98 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

K0859_HUMAN
NC score	0.126787 (rank : 13)	θ value	4.45536e-07 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6R0, O94940, Q5TGP9, Q5TGQ0, Q8N2P8, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6	Gene names	KIAA0859
Domain Architecture	No domain graphic available
Description	Protein KIAA0859.

K0859_MOUSE
NC score	0.121849 (rank : 14)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YR5, Q3TFY3, Q69ZX4, Q8BWN2, Q8BX81	Gene names	Kiaa0859
Domain Architecture	No domain graphic available
Description	Protein KIAA0859.

TTF1_MOUSE
NC score	0.012552 (rank : 15)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	277	Shared Neighborhood Hits	2
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

CPVL_HUMAN
NC score	0.009434 (rank : 16)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3G5, Q6UX20, Q8NBL7, Q96AR7, Q9HB41	Gene names	CPVL, VLP
Domain Architecture
Description	Probable serine carboxypeptidase CPVL precursor (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase- like protein) (VCP-like protein) (HVLP).

CC023_HUMAN
NC score	0.007846 (rank : 17)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3R3, Q495R1, Q495R3, Q6GMU8	Gene names	C3orf23
Domain Architecture	No domain graphic available
Description	Protein C3orf23.

DHX35_HUMAN
NC score	0.005798 (rank : 18)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H5Z1, Q5THR0, Q9H4H7, Q9H6T6	Gene names	DHX35, C20orf15, DDX35
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX35 (EC 3.6.1.-) (DEAH box protein 35).