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Network neighborhood for query Sequence : ECE1_MOUSE

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ECE1_MOUSE
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ECE1_HUMAN
θ value	0 (rank : 1)	NC score	0.999493 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE2_HUMAN
θ value	0 (rank : 3)	NC score	0.993360 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

MMEL1_HUMAN
θ value	3.4876e-161 (rank : 4)	NC score	0.979047 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
θ value	5.94893e-161 (rank : 5)	NC score	0.978546 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_HUMAN
θ value	2.95929e-152 (rank : 6)	NC score	0.976912 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
θ value	3.27187e-151 (rank : 7)	NC score	0.976810 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ECEL1_HUMAN
θ value	9.85132e-148 (rank : 8)	NC score	0.978396 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
θ value	2.19465e-147 (rank : 9)	NC score	0.978215 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

PHEX_HUMAN
θ value	3.76091e-131 (rank : 10)	NC score	0.972078 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
θ value	1.33764e-128 (rank : 11)	NC score	0.971782 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

KELL_HUMAN
θ value	1.54472e-92 (rank : 12)	NC score	0.963860 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

RBCC1_MOUSE
θ value	1.38821 (rank : 13)	NC score	0.011362 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	1048	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

SPA3A_MOUSE
θ value	1.38821 (rank : 14)	NC score	0.007480 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4P1, Q9D490	Gene names	Serpina3a
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor A3A precursor (Serpin A3A).

TGT_MOUSE
θ value	1.38821 (rank : 15)	NC score	0.031849 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMA2	Gene names	Qtrt1, Tgt, Tgut
Domain Architecture
Description	Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (tRNA-guanine transglycosylase) (Guanine insertion enzyme).

EFCB3_MOUSE
θ value	1.81305 (rank : 16)	NC score	0.027680 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80X60	Gene names	Efcab3
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 3.

TNPO1_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.013297 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	3.0926 (rank : 18)	NC score	0.013316 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

FOXJ3_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.007162 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FOXJ3_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.007128 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

ECHB_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.005795 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

NF1_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.017060 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.017009 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

Hits sorted by NC score

ECE1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_HUMAN
NC score	0.999493 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE2_HUMAN
NC score	0.993360 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

MMEL1_HUMAN
NC score	0.979047 (rank : 4)	θ value	3.4876e-161 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
NC score	0.978546 (rank : 5)	θ value	5.94893e-161 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

ECEL1_HUMAN
NC score	0.978396 (rank : 6)	θ value	9.85132e-148 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
NC score	0.978215 (rank : 7)	θ value	2.19465e-147 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

NEP_HUMAN
NC score	0.976912 (rank : 8)	θ value	2.95929e-152 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
NC score	0.976810 (rank : 9)	θ value	3.27187e-151 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

PHEX_HUMAN
NC score	0.972078 (rank : 10)	θ value	3.76091e-131 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
NC score	0.971782 (rank : 11)	θ value	1.33764e-128 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

KELL_HUMAN
NC score	0.963860 (rank : 12)	θ value	1.54472e-92 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

TGT_MOUSE
NC score	0.031849 (rank : 13)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMA2	Gene names	Qtrt1, Tgt, Tgut
Domain Architecture
Description	Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (tRNA-guanine transglycosylase) (Guanine insertion enzyme).

EFCB3_MOUSE
NC score	0.027680 (rank : 14)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80X60	Gene names	Efcab3
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 3.

NF1_HUMAN
NC score	0.017060 (rank : 15)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.017009 (rank : 16)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

TNPO1_MOUSE
NC score	0.013316 (rank : 17)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO1_HUMAN
NC score	0.013297 (rank : 18)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

RBCC1_MOUSE
NC score	0.011362 (rank : 19)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	1048	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

SPA3A_MOUSE
NC score	0.007480 (rank : 20)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4P1, Q9D490	Gene names	Serpina3a
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor A3A precursor (Serpin A3A).

FOXJ3_HUMAN
NC score	0.007162 (rank : 21)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FOXJ3_MOUSE
NC score	0.007128 (rank : 22)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

ECHB_HUMAN
NC score	0.005795 (rank : 23)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].