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Network neighborhood for query Sequence : TFPI2_HUMAN

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TFPI2_HUMAN
SwissProt Accessions	P48307	Gene names	TFPI2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2) (Placental protein 5) (PP5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TFPI2_HUMAN
θ value	6.01832e-121 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P48307	Gene names	TFPI2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2) (Placental protein 5) (PP5).

TFPI2_MOUSE
θ value	2.17557e-62 (rank : 2)	NC score	0.981915 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	O35536	Gene names	Tfpi2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2).

TFPI1_HUMAN
θ value	4.28545e-26 (rank : 3)	NC score	0.902584 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P10646, O95103	Gene names	TFPI, LACI, TFPI1
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

TFPI1_MOUSE
θ value	2.59989e-23 (rank : 4)	NC score	0.888493 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	22	Shared Neighborhood Hits	20
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

SPIT1_MOUSE
θ value	2.69047e-20 (rank : 5)	NC score	0.722076 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_HUMAN
θ value	1.02238e-19 (rank : 6)	NC score	0.697176 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT2_HUMAN
θ value	1.68911e-14 (rank : 7)	NC score	0.829780 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	O43291, O00271, O14895, Q5TZQ3, Q969E0	Gene names	SPINT2, HAI2, KOP
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin).

SPIT2_MOUSE
θ value	2.20605e-14 (rank : 8)	NC score	0.824458 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WU03, Q9WU04, Q9WU05	Gene names	Spint2, Hai2
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2).

AMBP_MOUSE
θ value	9.26847e-13 (rank : 9)	NC score	0.674093 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q07456, Q61294	Gene names	Ambp, Itil
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin; Inter-alpha- trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

AMBP_HUMAN
θ value	2.0648e-12 (rank : 10)	NC score	0.685516 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	P02760, P00977, P02759	Gene names	AMBP, HCP, ITIL
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

CO6A3_HUMAN
θ value	8.67504e-11 (rank : 11)	NC score	0.278543 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	317	Shared Neighborhood Hits	20
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

EPPI_MOUSE
θ value	7.34386e-10 (rank : 12)	NC score	0.745481 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DA01	Gene names	Spinlw1
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1).

CO7A1_HUMAN
θ value	4.76016e-09 (rank : 13)	NC score	0.146277 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	807	Shared Neighborhood Hits	20
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

EPPI_HUMAN
θ value	6.21693e-09 (rank : 14)	NC score	0.723511 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	O95925, Q86TP9, Q96SD7, Q9HD30	Gene names	SPINLW1, WAP7, WFDC7
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) (Protease inhibitor WAP7).

WFDC8_HUMAN
θ value	4.0297e-08 (rank : 15)	NC score	0.612926 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

A4_HUMAN
θ value	1.17247e-07 (rank : 16)	NC score	0.497613 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

A4_MOUSE
θ value	1.99992e-07 (rank : 17)	NC score	0.498223 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

APLP2_HUMAN
θ value	3.41135e-07 (rank : 18)	NC score	0.492061 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

SPIT3_HUMAN
θ value	1.09739e-05 (rank : 19)	NC score	0.830543 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P49223, Q6UDR8, Q96KK2	Gene names	SPINT3
Domain Architecture	No domain graphic available
Description	Kunitz-type protease inhibitor 3 precursor (HKIB9).

WFDC6_HUMAN
θ value	0.163984 (rank : 20)	NC score	0.442519 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQY6, Q5JYQ4, Q8NFV6	Gene names	WFDC6, C20orf171, WAP6
Domain Architecture
Description	WAP four-disulfide core domain protein 6 precursor (Putative protease inhibitor WAP6).

EGFR_HUMAN
θ value	0.279714 (rank : 21)	NC score	0.012335 (rank : 42)
Query Neighborhood Hits	24	Target Neighborhood Hits	939	Shared Neighborhood Hits	4
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

ERBB4_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.012881 (rank : 41)
Query Neighborhood Hits	24	Target Neighborhood Hits	910	Shared Neighborhood Hits	6
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EGFR_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.010726 (rank : 43)
Query Neighborhood Hits	24	Target Neighborhood Hits	927	Shared Neighborhood Hits	4
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

MEP1A_MOUSE
θ value	4.03905 (rank : 24)	NC score	0.012893 (rank : 40)
Query Neighborhood Hits	24	Target Neighborhood Hits	166	Shared Neighborhood Hits	2
SwissProt Accessions	P28825	Gene names	Mep1a
Domain Architecture
Description	Meprin A subunit alpha precursor (EC 3.4.24.18) (Endopeptidase-2) (MEP-1).

ALK1_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.055145 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P03973, P07757	Gene names	SLPI, WAP4, WFDC4
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (HUSI-1) (Seminal proteinase inhibitor) (Secretory leukocyte protease inhibitor) (BLPI) (Mucus proteinase inhibitor) (MPI) (WAP four-disulfide core domain protein 4) (Protease inhibitor WAP4).

ALK1_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.061098 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P97430, O09081, O09082	Gene names	Slpi
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (Secretory leukocyte protease inhibitor).

APLP1_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.119011 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P51693, O00113, Q96A92	Gene names	APLP1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP1_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.118770 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP2_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.141380 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

CO8G_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.084839 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P07360, Q5SQ07	Gene names	C8G
Domain Architecture
Description	Complement component C8 gamma chain precursor.

CO8G_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.089643 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCG4	Gene names	C8g
Domain Architecture
Description	Complement component C8 gamma chain precursor.

ELAF_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.050851 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P19957	Gene names	PI3, WAP3, WFDC14
Domain Architecture
Description	Elafin precursor (Elastase-specific inhibitor) (ESI) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14) (Protease inhibitor WAP3).

LRP11_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.109220 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP11_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.109906 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

NGAL_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.063167 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P80188, P30150, Q92683	Gene names	LCN2, HNL, NGAL
Domain Architecture
Description	Neutrophil gelatinase-associated lipocalin precursor (NGAL) (p25) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3).

PTGDS_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.074756 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41222, Q5SQ10, Q7M4P3, Q9UCC9, Q9UCD9	Gene names	PTGDS, PDS
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-28).

PTGDS_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.070611 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	O09114, O09157, O35091, Q62169	Gene names	Ptgds
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS).

VITRN_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.051086 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UXI7, Q6P7T3, Q96DT1	Gene names	VIT
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

VITRN_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.051316 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHI5, Q3TZ47, Q8BQ41, Q8K047, Q9CYZ1	Gene names	Vit
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

WFD12_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.061199 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWY7, Q5H980, Q9BR31	Gene names	WFDC12, C20orf122, WAP2
Domain Architecture
Description	WAP four-disulfide core domain protein 12 precursor (Putative protease inhibitor WAP12) (Whey acidic protein 2).

WFD12_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.068114 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY3	Gene names	Wfdc12, Swam2
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 12 precursor (Whey acidic protein 2) (Single WAP motif protein 2) (Elafin-like protein II).

WFD15_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.111230 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY4, Q8BVC0	Gene names	Wfdc15, Swam1
Domain Architecture
Description	WAP four-disulfide core domain protein 15 precursor (Single WAP motif protein 1) (Elafin-like protein I).

WFDC5_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.056288 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TCV5, Q6UWE4	Gene names	WFDC5, WAP1
Domain Architecture
Description	WAP four-disulfide core domain protein 5 precursor (Putative protease inhibitor WAP1).

Hits sorted by NC score

TFPI2_HUMAN
NC score	0.999962 (rank : 1)	θ value	6.01832e-121 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P48307	Gene names	TFPI2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2) (Placental protein 5) (PP5).

TFPI2_MOUSE
NC score	0.981915 (rank : 2)	θ value	2.17557e-62 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	O35536	Gene names	Tfpi2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2).

TFPI1_HUMAN
NC score	0.902584 (rank : 3)	θ value	4.28545e-26 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P10646, O95103	Gene names	TFPI, LACI, TFPI1
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

TFPI1_MOUSE
NC score	0.888493 (rank : 4)	θ value	2.59989e-23 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	22	Shared Neighborhood Hits	20
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

SPIT3_HUMAN
NC score	0.830543 (rank : 5)	θ value	1.09739e-05 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P49223, Q6UDR8, Q96KK2	Gene names	SPINT3
Domain Architecture	No domain graphic available
Description	Kunitz-type protease inhibitor 3 precursor (HKIB9).

SPIT2_HUMAN
NC score	0.829780 (rank : 6)	θ value	1.68911e-14 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	O43291, O00271, O14895, Q5TZQ3, Q969E0	Gene names	SPINT2, HAI2, KOP
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin).

SPIT2_MOUSE
NC score	0.824458 (rank : 7)	θ value	2.20605e-14 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WU03, Q9WU04, Q9WU05	Gene names	Spint2, Hai2
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2).

EPPI_MOUSE
NC score	0.745481 (rank : 8)	θ value	7.34386e-10 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DA01	Gene names	Spinlw1
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1).

EPPI_HUMAN
NC score	0.723511 (rank : 9)	θ value	6.21693e-09 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	O95925, Q86TP9, Q96SD7, Q9HD30	Gene names	SPINLW1, WAP7, WFDC7
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) (Protease inhibitor WAP7).

SPIT1_MOUSE
NC score	0.722076 (rank : 10)	θ value	2.69047e-20 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_HUMAN
NC score	0.697176 (rank : 11)	θ value	1.02238e-19 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

AMBP_HUMAN
NC score	0.685516 (rank : 12)	θ value	2.0648e-12 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	P02760, P00977, P02759	Gene names	AMBP, HCP, ITIL
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

AMBP_MOUSE
NC score	0.674093 (rank : 13)	θ value	9.26847e-13 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q07456, Q61294	Gene names	Ambp, Itil
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin; Inter-alpha- trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

WFDC8_HUMAN
NC score	0.612926 (rank : 14)	θ value	4.0297e-08 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

A4_MOUSE
NC score	0.498223 (rank : 15)	θ value	1.99992e-07 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

A4_HUMAN
NC score	0.497613 (rank : 16)	θ value	1.17247e-07 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

APLP2_HUMAN
NC score	0.492061 (rank : 17)	θ value	3.41135e-07 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

WFDC6_HUMAN
NC score	0.442519 (rank : 18)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQY6, Q5JYQ4, Q8NFV6	Gene names	WFDC6, C20orf171, WAP6
Domain Architecture
Description	WAP four-disulfide core domain protein 6 precursor (Putative protease inhibitor WAP6).

CO6A3_HUMAN
NC score	0.278543 (rank : 19)	θ value	8.67504e-11 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	317	Shared Neighborhood Hits	20
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

CO7A1_HUMAN
NC score	0.146277 (rank : 20)	θ value	4.76016e-09 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	807	Shared Neighborhood Hits	20
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

APLP2_MOUSE
NC score	0.141380 (rank : 21)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

APLP1_HUMAN
NC score	0.119011 (rank : 22)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P51693, O00113, Q96A92	Gene names	APLP1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP1_MOUSE
NC score	0.118770 (rank : 23)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

WFD15_MOUSE
NC score	0.111230 (rank : 24)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY4, Q8BVC0	Gene names	Wfdc15, Swam1
Domain Architecture
Description	WAP four-disulfide core domain protein 15 precursor (Single WAP motif protein 1) (Elafin-like protein I).

LRP11_MOUSE
NC score	0.109906 (rank : 25)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP11_HUMAN
NC score	0.109220 (rank : 26)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

CO8G_MOUSE
NC score	0.089643 (rank : 27)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCG4	Gene names	C8g
Domain Architecture
Description	Complement component C8 gamma chain precursor.

CO8G_HUMAN
NC score	0.084839 (rank : 28)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P07360, Q5SQ07	Gene names	C8G
Domain Architecture
Description	Complement component C8 gamma chain precursor.

PTGDS_HUMAN
NC score	0.074756 (rank : 29)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41222, Q5SQ10, Q7M4P3, Q9UCC9, Q9UCD9	Gene names	PTGDS, PDS
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-28).

PTGDS_MOUSE
NC score	0.070611 (rank : 30)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	O09114, O09157, O35091, Q62169	Gene names	Ptgds
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS).

WFD12_MOUSE
NC score	0.068114 (rank : 31)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY3	Gene names	Wfdc12, Swam2
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 12 precursor (Whey acidic protein 2) (Single WAP motif protein 2) (Elafin-like protein II).

NGAL_HUMAN
NC score	0.063167 (rank : 32)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P80188, P30150, Q92683	Gene names	LCN2, HNL, NGAL
Domain Architecture
Description	Neutrophil gelatinase-associated lipocalin precursor (NGAL) (p25) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3).

WFD12_HUMAN
NC score	0.061199 (rank : 33)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	24	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWY7, Q5H980, Q9BR31	Gene names	WFDC12, C20orf122, WAP2
Domain Architecture
Description	WAP four-disulfide core domain protein 12 precursor (Putative protease inhibitor WAP12) (Whey acidic protein 2).

ALK1_MOUSE
NC score	0.061098 (rank : 34)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P97430, O09081, O09082	Gene names	Slpi
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (Secretory leukocyte protease inhibitor).

WFDC5_HUMAN
NC score	0.056288 (rank : 35)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	24	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TCV5, Q6UWE4	Gene names	WFDC5, WAP1
Domain Architecture
Description	WAP four-disulfide core domain protein 5 precursor (Putative protease inhibitor WAP1).

ALK1_HUMAN
NC score	0.055145 (rank : 36)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P03973, P07757	Gene names	SLPI, WAP4, WFDC4
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (HUSI-1) (Seminal proteinase inhibitor) (Secretory leukocyte protease inhibitor) (BLPI) (Mucus proteinase inhibitor) (MPI) (WAP four-disulfide core domain protein 4) (Protease inhibitor WAP4).

VITRN_MOUSE
NC score	0.051316 (rank : 37)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHI5, Q3TZ47, Q8BQ41, Q8K047, Q9CYZ1	Gene names	Vit
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

VITRN_HUMAN
NC score	0.051086 (rank : 38)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UXI7, Q6P7T3, Q96DT1	Gene names	VIT
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

ELAF_HUMAN
NC score	0.050851 (rank : 39)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P19957	Gene names	PI3, WAP3, WFDC14
Domain Architecture
Description	Elafin precursor (Elastase-specific inhibitor) (ESI) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14) (Protease inhibitor WAP3).

MEP1A_MOUSE
NC score	0.012893 (rank : 40)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	166	Shared Neighborhood Hits	2
SwissProt Accessions	P28825	Gene names	Mep1a
Domain Architecture
Description	Meprin A subunit alpha precursor (EC 3.4.24.18) (Endopeptidase-2) (MEP-1).

ERBB4_HUMAN
NC score	0.012881 (rank : 41)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	910	Shared Neighborhood Hits	6
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EGFR_HUMAN
NC score	0.012335 (rank : 42)	θ value	0.279714 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	939	Shared Neighborhood Hits	4
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.010726 (rank : 43)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	927	Shared Neighborhood Hits	4
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).