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Network neighborhood for query Sequence : SYNC_HUMAN

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SYNC_HUMAN
SwissProt Accessions	O43776	Gene names	NARS, ASNS
Domain Architecture
Description	Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine-- tRNA ligase) (AsnRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYNC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O43776	Gene names	NARS, ASNS
Domain Architecture
Description	Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine-- tRNA ligase) (AsnRS).

SYNC_MOUSE
θ value	0 (rank : 2)	NC score	0.994435 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BP47, Q9CRY5	Gene names	Nars
Domain Architecture
Description	Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine-- tRNA ligase) (AsnRS).

SYNM_MOUSE
θ value	2.18568e-46 (rank : 3)	NC score	0.846796 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	14	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGV0	Gene names	Nars2
Domain Architecture	No domain graphic available
Description	Probable asparaginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.22) (Asparagine--tRNA ligase) (AsnRS).

SYNM_HUMAN
θ value	1.85029e-45 (rank : 4)	NC score	0.842686 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I59	Gene names	NARS2
Domain Architecture	No domain graphic available
Description	Probable asparaginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.22) (Asparagine--tRNA ligase) (AsnRS).

SYDC_MOUSE
θ value	3.16345e-37 (rank : 5)	NC score	0.787759 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q922B2	Gene names	Dars
Domain Architecture
Description	Aspartyl-tRNA synthetase, cytoplasmic (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYDC_HUMAN
θ value	5.96599e-36 (rank : 6)	NC score	0.786652 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P14868, Q2TNI3, Q32Q69, Q53HV4, Q53YC5, Q9BW52	Gene names	DARS, PIG40
Domain Architecture
Description	Aspartyl-tRNA synthetase, cytoplasmic (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS) (Cell proliferation-inducing gene 40 protein).

SYDM_HUMAN
θ value	4.0297e-08 (rank : 7)	NC score	0.430917 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PI48	Gene names	DARS2
Domain Architecture	No domain graphic available
Description	Aspartyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYK_HUMAN
θ value	0.00035302 (rank : 8)	NC score	0.361189 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q15046, O14946, Q96J25	Gene names	KARS, KIAA0070
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

SYDM_MOUSE
θ value	0.00134147 (rank : 9)	NC score	0.395626 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BIP0, Q5FWV4	Gene names	Dars2
Domain Architecture	No domain graphic available
Description	Aspartyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYK_MOUSE
θ value	0.0113563 (rank : 10)	NC score	0.343804 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MN1	Gene names	Kars
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

TAF3_MOUSE
θ value	0.0563607 (rank : 11)	NC score	0.075847 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	463	Shared Neighborhood Hits	11
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

CCD45_MOUSE
θ value	0.0736092 (rank : 12)	NC score	0.078949 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	663	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

MAP1B_MOUSE
θ value	0.279714 (rank : 13)	NC score	0.041117 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	977	Shared Neighborhood Hits	11
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

RHEB_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.020299 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q15382, Q99444	Gene names	RHEB, RHEB2
Domain Architecture
Description	GTP-binding protein Rheb (Ras homolog enriched in brain).

CCD45_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.059157 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	525	Shared Neighborhood Hits	20
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

RHEB_MOUSE
θ value	0.47712 (rank : 16)	NC score	0.019462 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q921J2	Gene names	Rheb
Domain Architecture
Description	GTP-binding protein Rheb (Ras homolog enriched in brain).

EHMT2_MOUSE
θ value	0.62314 (rank : 17)	NC score	0.023464 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	750	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.023832 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	498	Shared Neighborhood Hits	7
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

SFR17_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.048085 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	325	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

M4K4_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.009172 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	1589	Shared Neighborhood Hits	14
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.009173 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	1560	Shared Neighborhood Hits	15
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

BRD9_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.035068 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

OFD1_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.023127 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	753	Shared Neighborhood Hits	10
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

ARI4A_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.029476 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	434	Shared Neighborhood Hits	12
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

GRLF1_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.014133 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

TAF3_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.053378 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	568	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

AKA12_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.035252 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CNGA1_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.018835 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CALD1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.010414 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	959	Shared Neighborhood Hits	11
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CD2L1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.006419 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	1467	Shared Neighborhood Hits	11
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.005948 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	1463	Shared Neighborhood Hits	12
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.006426 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	1439	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

EEA1_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.009083 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	1796	Shared Neighborhood Hits	22
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

HTSF1_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.034315 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	408	Shared Neighborhood Hits	7
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

MYO7A_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.008577 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

P66A_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.032334 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

ABCF1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.010733 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NE71, O14897, Q69YP6	Gene names	ABCF1, ABC50
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein).

CDR2_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.013371 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	482	Shared Neighborhood Hits	7
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CYLC2_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.040089 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	223	Shared Neighborhood Hits	7
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

PARP8_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.013446 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

AKAP2_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.012034 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

IF2P_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.009762 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	889	Shared Neighborhood Hits	7
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

JOSD3_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.020430 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D4V4, Q149X7, Q8C7I5, Q9CZG0, Q9D5U6	Gene names	Josd3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

RAD50_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.011551 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	1317	Shared Neighborhood Hits	23
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

U2AFL_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.011676 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	389	Shared Neighborhood Hits	7
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

MAP1B_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.030911 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	903	Shared Neighborhood Hits	13
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MYO7A_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.006724 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	209	Shared Neighborhood Hits	4
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

Hits sorted by NC score

SYNC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O43776	Gene names	NARS, ASNS
Domain Architecture
Description	Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine-- tRNA ligase) (AsnRS).

SYNC_MOUSE
NC score	0.994435 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BP47, Q9CRY5	Gene names	Nars
Domain Architecture
Description	Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine-- tRNA ligase) (AsnRS).

SYNM_MOUSE
NC score	0.846796 (rank : 3)	θ value	2.18568e-46 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	14	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGV0	Gene names	Nars2
Domain Architecture	No domain graphic available
Description	Probable asparaginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.22) (Asparagine--tRNA ligase) (AsnRS).

SYNM_HUMAN
NC score	0.842686 (rank : 4)	θ value	1.85029e-45 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I59	Gene names	NARS2
Domain Architecture	No domain graphic available
Description	Probable asparaginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.22) (Asparagine--tRNA ligase) (AsnRS).

SYDC_MOUSE
NC score	0.787759 (rank : 5)	θ value	3.16345e-37 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q922B2	Gene names	Dars
Domain Architecture
Description	Aspartyl-tRNA synthetase, cytoplasmic (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYDC_HUMAN
NC score	0.786652 (rank : 6)	θ value	5.96599e-36 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P14868, Q2TNI3, Q32Q69, Q53HV4, Q53YC5, Q9BW52	Gene names	DARS, PIG40
Domain Architecture
Description	Aspartyl-tRNA synthetase, cytoplasmic (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS) (Cell proliferation-inducing gene 40 protein).

SYDM_HUMAN
NC score	0.430917 (rank : 7)	θ value	4.0297e-08 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PI48	Gene names	DARS2
Domain Architecture	No domain graphic available
Description	Aspartyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYDM_MOUSE
NC score	0.395626 (rank : 8)	θ value	0.00134147 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BIP0, Q5FWV4	Gene names	Dars2
Domain Architecture	No domain graphic available
Description	Aspartyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

SYK_HUMAN
NC score	0.361189 (rank : 9)	θ value	0.00035302 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q15046, O14946, Q96J25	Gene names	KARS, KIAA0070
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

SYK_MOUSE
NC score	0.343804 (rank : 10)	θ value	0.0113563 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MN1	Gene names	Kars
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

CCD45_MOUSE
NC score	0.078949 (rank : 11)	θ value	0.0736092 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	663	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

TAF3_MOUSE
NC score	0.075847 (rank : 12)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	463	Shared Neighborhood Hits	11
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

CCD45_HUMAN
NC score	0.059157 (rank : 13)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	525	Shared Neighborhood Hits	20
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

TAF3_HUMAN
NC score	0.053378 (rank : 14)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	568	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

SFR17_HUMAN
NC score	0.048085 (rank : 15)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	325	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

MAP1B_MOUSE
NC score	0.041117 (rank : 16)	θ value	0.279714 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	977	Shared Neighborhood Hits	11
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

CYLC2_HUMAN
NC score	0.040089 (rank : 17)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	223	Shared Neighborhood Hits	7
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

AKA12_HUMAN
NC score	0.035252 (rank : 18)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

BRD9_MOUSE
NC score	0.035068 (rank : 19)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

HTSF1_HUMAN
NC score	0.034315 (rank : 20)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	408	Shared Neighborhood Hits	7
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

P66A_HUMAN
NC score	0.032334 (rank : 21)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

MAP1B_HUMAN
NC score	0.030911 (rank : 22)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	903	Shared Neighborhood Hits	13
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

ARI4A_HUMAN
NC score	0.029476 (rank : 23)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	434	Shared Neighborhood Hits	12
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

EHMT2_HUMAN
NC score	0.023832 (rank : 24)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	498	Shared Neighborhood Hits	7
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_MOUSE
NC score	0.023464 (rank : 25)	θ value	0.62314 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	750	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

OFD1_HUMAN
NC score	0.023127 (rank : 26)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	753	Shared Neighborhood Hits	10
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

JOSD3_MOUSE
NC score	0.020430 (rank : 27)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D4V4, Q149X7, Q8C7I5, Q9CZG0, Q9D5U6	Gene names	Josd3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

RHEB_HUMAN
NC score	0.020299 (rank : 28)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q15382, Q99444	Gene names	RHEB, RHEB2
Domain Architecture
Description	GTP-binding protein Rheb (Ras homolog enriched in brain).

RHEB_MOUSE
NC score	0.019462 (rank : 29)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q921J2	Gene names	Rheb
Domain Architecture
Description	GTP-binding protein Rheb (Ras homolog enriched in brain).

CNGA1_HUMAN
NC score	0.018835 (rank : 30)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

GRLF1_HUMAN
NC score	0.014133 (rank : 31)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

PARP8_HUMAN
NC score	0.013446 (rank : 32)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

CDR2_MOUSE
NC score	0.013371 (rank : 33)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	482	Shared Neighborhood Hits	7
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

AKAP2_HUMAN
NC score	0.012034 (rank : 34)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

U2AFL_MOUSE
NC score	0.011676 (rank : 35)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	389	Shared Neighborhood Hits	7
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

RAD50_HUMAN
NC score	0.011551 (rank : 36)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	1317	Shared Neighborhood Hits	23
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

ABCF1_HUMAN
NC score	0.010733 (rank : 37)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NE71, O14897, Q69YP6	Gene names	ABCF1, ABC50
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein).

CALD1_HUMAN
NC score	0.010414 (rank : 38)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	959	Shared Neighborhood Hits	11
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

IF2P_HUMAN
NC score	0.009762 (rank : 39)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	889	Shared Neighborhood Hits	7
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

M4K4_MOUSE
NC score	0.009173 (rank : 40)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	1560	Shared Neighborhood Hits	15
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_HUMAN
NC score	0.009172 (rank : 41)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	1589	Shared Neighborhood Hits	14
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

EEA1_HUMAN
NC score	0.009083 (rank : 42)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	1796	Shared Neighborhood Hits	22
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

MYO7A_MOUSE
NC score	0.008577 (rank : 43)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_HUMAN
NC score	0.006724 (rank : 44)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	209	Shared Neighborhood Hits	4
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

CD2L2_HUMAN
NC score	0.006426 (rank : 45)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	1439	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L1_HUMAN
NC score	0.006419 (rank : 46)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	1467	Shared Neighborhood Hits	11
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
NC score	0.005948 (rank : 47)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	1463	Shared Neighborhood Hits	12
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).