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Network neighborhood for query Sequence : NLGN3_MOUSE

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NLGN3_MOUSE
SwissProt Accessions	Q8BYM5, Q8BXR4	Gene names	Nlgn3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NLGN1_HUMAN
θ value	0 (rank : 1)	NC score	0.996875 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N2Q7, Q9UPT2	Gene names	NLGN1, KIAA1070
Domain Architecture
Description	Neuroligin-1 precursor.

NLGN1_MOUSE
θ value	0 (rank : 2)	NC score	0.996909 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q99K10	Gene names	Nlgn1, Kiaa1070
Domain Architecture
Description	Neuroligin-1 precursor.

NLGN2_HUMAN
θ value	0 (rank : 3)	NC score	0.994902 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NFZ4, Q9P2I1	Gene names	NLGN2, KIAA1366
Domain Architecture
Description	Neuroligin-2 precursor.

NLGN2_MOUSE
θ value	0 (rank : 4)	NC score	0.995058 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q69ZK9, Q5F288	Gene names	Nlgn2, Kiaa1366
Domain Architecture	No domain graphic available
Description	Neuroligin-2 precursor.

NLGN3_HUMAN
θ value	0 (rank : 5)	NC score	0.999709 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	45	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZ94, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248	Gene names	NLGN3, KIAA1480, NL3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGN3_MOUSE
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BYM5, Q8BXR4	Gene names	Nlgn3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGNX_HUMAN
θ value	0 (rank : 7)	NC score	0.997770 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N0W4, Q6UX10, Q9ULG0	Gene names	NLGN4X, KIAA1260, NLGN4
Domain Architecture
Description	Neuroligin-4, X-linked precursor (Neuroligin X) (HNLX).

NLGNY_HUMAN
θ value	0 (rank : 8)	NC score	0.997654 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NFZ3, Q7Z3T5, Q9Y2F8	Gene names	NLGN4Y, KIAA0951
Domain Architecture
Description	Neuroligin-4, Y-linked precursor (Neuroligin Y).

ACES_MOUSE
θ value	5.32145e-85 (rank : 9)	NC score	0.948071 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	P21836	Gene names	Ache
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

ACES_HUMAN
θ value	2.02215e-84 (rank : 10)	NC score	0.947251 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	P22303, Q16169, Q86TM9, Q9BXP7	Gene names	ACHE
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

CHLE_HUMAN
θ value	5.69867e-79 (rank : 11)	NC score	0.945462 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	P06276	Gene names	BCHE, CHE1
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

CHLE_MOUSE
θ value	2.1655e-78 (rank : 12)	NC score	0.945043 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q03311	Gene names	Bche
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

EST2_HUMAN
θ value	8.22888e-78 (rank : 13)	NC score	0.946899 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	O00748, Q16859, Q5MAB8, Q7Z366, Q8IUP4, Q8TCP8	Gene names	CES2, ICE
Domain Architecture
Description	Carboxylesterase 2 precursor (EC 3.1.1.1) (CE-2) (hCE-2).

CEL_HUMAN
θ value	1.8332e-77 (rank : 14)	NC score	0.722972 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	896	Shared Neighborhood Hits	33
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

EST1_HUMAN
θ value	5.33382e-77 (rank : 15)	NC score	0.931574 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P23141, Q00015, Q13657, Q14062, Q16737, Q16788, Q86UK2, Q96EE8, Q9UK77, Q9ULY2	Gene names	CES1, CES2, SES1
Domain Architecture
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ACAT) (Monocyte/macrophage serine esterase) (HMSE) (Serine esterase 1) (Brain carboxylesterase hBr1) (Triacylglycerol hydrolase) (TGH) (Egasyn).

CEL_MOUSE
θ value	1.71583e-75 (rank : 16)	NC score	0.952184 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CES3_MOUSE
θ value	4.99229e-75 (rank : 17)	NC score	0.929683 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

EST31_MOUSE
θ value	2.73936e-73 (rank : 18)	NC score	0.946308 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q63880	Gene names	Es31
Domain Architecture
Description	Liver carboxylesterase 31 precursor (EC 3.1.1.1) (ES-Male) (Esterase- 31).

EST22_MOUSE
θ value	2.56397e-71 (rank : 19)	NC score	0.931006 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q64176	Gene names	Es22
Domain Architecture
Description	Liver carboxylesterase 22 precursor (EC 3.1.1.1) (Egasyn) (Esterase- 22) (Es-22).

EST1_MOUSE
θ value	1.83746e-69 (rank : 20)	NC score	0.926832 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCC2, O55136	Gene names	Ces1
Domain Architecture	No domain graphic available
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ES-x).

ESTN_MOUSE
θ value	2.03155e-68 (rank : 21)	NC score	0.929073 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	P23953, O54936, P11374, Q8K125	Gene names	Es1
Domain Architecture
Description	Liver carboxylesterase N precursor (EC 3.1.1.1) (PES-N) (Lung surfactant convertase).

THYG_MOUSE
θ value	7.01481e-53 (rank : 22)	NC score	0.810189 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

THYG_HUMAN
θ value	3.85808e-43 (rank : 23)	NC score	0.791138 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

CSKI1_HUMAN
θ value	0.279714 (rank : 24)	NC score	0.011958 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	997	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SMR3B_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.102478 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

RC3H1_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.017944 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

MUC2_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.021504 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	906	Shared Neighborhood Hits	10
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SMRD2_MOUSE
θ value	2.36792 (rank : 28)	NC score	0.011426 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JR8	Gene names	Smarcd2, Baf60b
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B).

TITIN_HUMAN
θ value	2.36792 (rank : 29)	NC score	-0.000538 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	2923	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

IQEC2_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.010560 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	403	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.010506 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

TTBK2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.003334 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	822	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

ELF1_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.006664 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P32519, Q9UDE1	Gene names	ELF1
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

ELF1_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.006639 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

OMD_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.003043 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	275	Shared Neighborhood Hits	3
SwissProt Accessions	O35103	Gene names	Omd
Domain Architecture
Description	Osteomodulin precursor (Osteoadherin) (OSAD) (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin).

BUB1B_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.006940 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CBP_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.006217 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	941	Shared Neighborhood Hits	7
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DNJA3_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.005816 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EY1, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96IV1, Q9NYH8	Gene names	DNAJA3, TID1
Domain Architecture
Description	DnaJ homolog subfamily A member 3, mitochondrial precursor (Tumorous imaginal discs protein Tid56 homolog) (DnaJ protein Tid-1) (hTid-1).

HGFA_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.000117 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	436	Shared Neighborhood Hits	3
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

MYEOV_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.030503 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	Q96EZ4, Q9UGN6, Q9UGN7	Gene names	MYEOV, OCIM
Domain Architecture	No domain graphic available
Description	Myeloma overexpressed gene protein (Oncogene in multiple myeloma).

TTBK2_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.002494 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ANR47_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.003916 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	369	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

CASC3_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.009168 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	333	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

MK04_HUMAN
θ value	6.88961 (rank : 44)	NC score	-0.002394 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	837	Shared Neighborhood Hits	6
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

CCP1_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.009391 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P53805, O00582, O00583, Q96R03, Q9BU69, Q9UF15, Q9UME4	Gene names	DSCR1, ADAPT78, CSP1, DSC1
Domain Architecture
Description	Calcipressin-1 (Down syndrome critical region protein 1) (Myocyte- enriched calcineurin-interacting protein 1) (MCIP1) (Adapt78).

CCP1_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.009317 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHG6, Q91WQ4, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3	Gene names	Dscr1
Domain Architecture
Description	Calcipressin-1 (Down syndrome critical region protein 1 homolog) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1).

DIAP1_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.017665 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	784	Shared Neighborhood Hits	7
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

FA5_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.003399 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

AAAD_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.206002 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P22760, Q8N1A9	Gene names	AADAC, DAC
Domain Architecture
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

AAAD_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.115782 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q99PG0, Q8VCF2	Gene names	Aadac, Aada
Domain Architecture	No domain graphic available
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

Hits sorted by NC score

NLGN3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BYM5, Q8BXR4	Gene names	Nlgn3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGN3_HUMAN
NC score	0.999709 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	45	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZ94, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248	Gene names	NLGN3, KIAA1480, NL3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGNX_HUMAN
NC score	0.997770 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N0W4, Q6UX10, Q9ULG0	Gene names	NLGN4X, KIAA1260, NLGN4
Domain Architecture
Description	Neuroligin-4, X-linked precursor (Neuroligin X) (HNLX).

NLGNY_HUMAN
NC score	0.997654 (rank : 4)	θ value	0 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NFZ3, Q7Z3T5, Q9Y2F8	Gene names	NLGN4Y, KIAA0951
Domain Architecture
Description	Neuroligin-4, Y-linked precursor (Neuroligin Y).

NLGN1_MOUSE
NC score	0.996909 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q99K10	Gene names	Nlgn1, Kiaa1070
Domain Architecture
Description	Neuroligin-1 precursor.

NLGN1_HUMAN
NC score	0.996875 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N2Q7, Q9UPT2	Gene names	NLGN1, KIAA1070
Domain Architecture
Description	Neuroligin-1 precursor.

NLGN2_MOUSE
NC score	0.995058 (rank : 7)	θ value	0 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q69ZK9, Q5F288	Gene names	Nlgn2, Kiaa1366
Domain Architecture	No domain graphic available
Description	Neuroligin-2 precursor.

NLGN2_HUMAN
NC score	0.994902 (rank : 8)	θ value	0 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NFZ4, Q9P2I1	Gene names	NLGN2, KIAA1366
Domain Architecture
Description	Neuroligin-2 precursor.

CEL_MOUSE
NC score	0.952184 (rank : 9)	θ value	1.71583e-75 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

ACES_MOUSE
NC score	0.948071 (rank : 10)	θ value	5.32145e-85 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	P21836	Gene names	Ache
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

ACES_HUMAN
NC score	0.947251 (rank : 11)	θ value	2.02215e-84 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	P22303, Q16169, Q86TM9, Q9BXP7	Gene names	ACHE
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

EST2_HUMAN
NC score	0.946899 (rank : 12)	θ value	8.22888e-78 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	O00748, Q16859, Q5MAB8, Q7Z366, Q8IUP4, Q8TCP8	Gene names	CES2, ICE
Domain Architecture
Description	Carboxylesterase 2 precursor (EC 3.1.1.1) (CE-2) (hCE-2).

EST31_MOUSE
NC score	0.946308 (rank : 13)	θ value	2.73936e-73 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q63880	Gene names	Es31
Domain Architecture
Description	Liver carboxylesterase 31 precursor (EC 3.1.1.1) (ES-Male) (Esterase- 31).

CHLE_HUMAN
NC score	0.945462 (rank : 14)	θ value	5.69867e-79 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	P06276	Gene names	BCHE, CHE1
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

CHLE_MOUSE
NC score	0.945043 (rank : 15)	θ value	2.1655e-78 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q03311	Gene names	Bche
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

EST1_HUMAN
NC score	0.931574 (rank : 16)	θ value	5.33382e-77 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P23141, Q00015, Q13657, Q14062, Q16737, Q16788, Q86UK2, Q96EE8, Q9UK77, Q9ULY2	Gene names	CES1, CES2, SES1
Domain Architecture
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ACAT) (Monocyte/macrophage serine esterase) (HMSE) (Serine esterase 1) (Brain carboxylesterase hBr1) (Triacylglycerol hydrolase) (TGH) (Egasyn).

EST22_MOUSE
NC score	0.931006 (rank : 17)	θ value	2.56397e-71 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q64176	Gene names	Es22
Domain Architecture
Description	Liver carboxylesterase 22 precursor (EC 3.1.1.1) (Egasyn) (Esterase- 22) (Es-22).

CES3_MOUSE
NC score	0.929683 (rank : 18)	θ value	4.99229e-75 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

ESTN_MOUSE
NC score	0.929073 (rank : 19)	θ value	2.03155e-68 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	P23953, O54936, P11374, Q8K125	Gene names	Es1
Domain Architecture
Description	Liver carboxylesterase N precursor (EC 3.1.1.1) (PES-N) (Lung surfactant convertase).

EST1_MOUSE
NC score	0.926832 (rank : 20)	θ value	1.83746e-69 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCC2, O55136	Gene names	Ces1
Domain Architecture	No domain graphic available
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ES-x).

THYG_MOUSE
NC score	0.810189 (rank : 21)	θ value	7.01481e-53 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

THYG_HUMAN
NC score	0.791138 (rank : 22)	θ value	3.85808e-43 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

CEL_HUMAN
NC score	0.722972 (rank : 23)	θ value	1.8332e-77 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	896	Shared Neighborhood Hits	33
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

AAAD_HUMAN
NC score	0.206002 (rank : 24)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P22760, Q8N1A9	Gene names	AADAC, DAC
Domain Architecture
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

AAAD_MOUSE
NC score	0.115782 (rank : 25)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q99PG0, Q8VCF2	Gene names	Aadac, Aada
Domain Architecture	No domain graphic available
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

SMR3B_HUMAN
NC score	0.102478 (rank : 26)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

MYEOV_HUMAN
NC score	0.030503 (rank : 27)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	Q96EZ4, Q9UGN6, Q9UGN7	Gene names	MYEOV, OCIM
Domain Architecture	No domain graphic available
Description	Myeloma overexpressed gene protein (Oncogene in multiple myeloma).

MUC2_HUMAN
NC score	0.021504 (rank : 28)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	906	Shared Neighborhood Hits	10
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

RC3H1_HUMAN
NC score	0.017944 (rank : 29)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

DIAP1_HUMAN
NC score	0.017665 (rank : 30)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	784	Shared Neighborhood Hits	7
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

CSKI1_HUMAN
NC score	0.011958 (rank : 31)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	997	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SMRD2_MOUSE
NC score	0.011426 (rank : 32)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JR8	Gene names	Smarcd2, Baf60b
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B).

IQEC2_HUMAN
NC score	0.010560 (rank : 33)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	403	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
NC score	0.010506 (rank : 34)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

CCP1_HUMAN
NC score	0.009391 (rank : 35)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P53805, O00582, O00583, Q96R03, Q9BU69, Q9UF15, Q9UME4	Gene names	DSCR1, ADAPT78, CSP1, DSC1
Domain Architecture
Description	Calcipressin-1 (Down syndrome critical region protein 1) (Myocyte- enriched calcineurin-interacting protein 1) (MCIP1) (Adapt78).

CCP1_MOUSE
NC score	0.009317 (rank : 36)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHG6, Q91WQ4, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3	Gene names	Dscr1
Domain Architecture
Description	Calcipressin-1 (Down syndrome critical region protein 1 homolog) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1).

CASC3_MOUSE
NC score	0.009168 (rank : 37)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	333	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

BUB1B_MOUSE
NC score	0.006940 (rank : 38)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

ELF1_HUMAN
NC score	0.006664 (rank : 39)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P32519, Q9UDE1	Gene names	ELF1
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

ELF1_MOUSE
NC score	0.006639 (rank : 40)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

CBP_HUMAN
NC score	0.006217 (rank : 41)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	941	Shared Neighborhood Hits	7
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DNJA3_HUMAN
NC score	0.005816 (rank : 42)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EY1, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96IV1, Q9NYH8	Gene names	DNAJA3, TID1
Domain Architecture
Description	DnaJ homolog subfamily A member 3, mitochondrial precursor (Tumorous imaginal discs protein Tid56 homolog) (DnaJ protein Tid-1) (hTid-1).

ANR47_HUMAN
NC score	0.003916 (rank : 43)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	369	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

FA5_HUMAN
NC score	0.003399 (rank : 44)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

TTBK2_HUMAN
NC score	0.003334 (rank : 45)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	822	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

OMD_MOUSE
NC score	0.003043 (rank : 46)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	275	Shared Neighborhood Hits	3
SwissProt Accessions	O35103	Gene names	Omd
Domain Architecture
Description	Osteomodulin precursor (Osteoadherin) (OSAD) (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin).

TTBK2_MOUSE
NC score	0.002494 (rank : 47)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

HGFA_HUMAN
NC score	0.000117 (rank : 48)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	436	Shared Neighborhood Hits	3
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TITIN_HUMAN
NC score	-0.000538 (rank : 49)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	2923	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MK04_HUMAN
NC score	-0.002394 (rank : 50)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	837	Shared Neighborhood Hits	6
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).