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Network neighborhood for query Sequence : HASP_HUMAN

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HASP_HUMAN
SwissProt Accessions	Q8TF76, Q5U5K3, Q96MN1, Q9BXS7	Gene names	GSG2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (H-Haspin) (Germ cell-specific gene 2 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HASP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TF76, Q5U5K3, Q96MN1, Q9BXS7	Gene names	GSG2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (H-Haspin) (Germ cell-specific gene 2 protein).

HASP_MOUSE
θ value	0 (rank : 2)	NC score	0.954341 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z0R0, Q99MU9, Q9JJJ4	Gene names	Gsg2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (Germ cell-specific gene 2 protein).

STK24_HUMAN
θ value	0.000602161 (rank : 3)	NC score	0.079702 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	853	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	0.000786445 (rank : 4)	NC score	0.079796 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	856	Shared Neighborhood Hits	37
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	0.00665767 (rank : 5)	NC score	0.075285 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	853	Shared Neighborhood Hits	36
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MST4_HUMAN
θ value	0.0113563 (rank : 6)	NC score	0.077719 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	852	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	0.0113563 (rank : 7)	NC score	0.077731 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	860	Shared Neighborhood Hits	37
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_MOUSE
θ value	0.0113563 (rank : 8)	NC score	0.075115 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	851	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

PTK6_HUMAN
θ value	0.0193708 (rank : 9)	NC score	0.059295 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	1020	Shared Neighborhood Hits	37
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

STK4_HUMAN
θ value	0.0193708 (rank : 10)	NC score	0.071663 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	0.0193708 (rank : 11)	NC score	0.071671 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	873	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

PTK6_MOUSE
θ value	0.0736092 (rank : 12)	NC score	0.058288 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	1026	Shared Neighborhood Hits	36
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

STK3_MOUSE
θ value	0.0736092 (rank : 13)	NC score	0.070930 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	869	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

MYCB2_MOUSE
θ value	0.0961366 (rank : 14)	NC score	0.079563 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	307	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

PAK2_MOUSE
θ value	0.125558 (rank : 15)	NC score	0.064673 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	858	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

WDR79_HUMAN
θ value	0.125558 (rank : 16)	NC score	0.046909 (rank : 110)
Query Neighborhood Hits	64	Target Neighborhood Hits	246	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

MYCB2_HUMAN
θ value	0.163984 (rank : 17)	NC score	0.080407 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	390	Shared Neighborhood Hits	12
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

STK3_HUMAN
θ value	0.163984 (rank : 18)	NC score	0.070533 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	861	Shared Neighborhood Hits	36
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PAK2_HUMAN
θ value	0.21417 (rank : 19)	NC score	0.064183 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	862	Shared Neighborhood Hits	36
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

NEK8_HUMAN
θ value	0.279714 (rank : 20)	NC score	0.060776 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	0.279714 (rank : 21)	NC score	0.061188 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

SRRM2_MOUSE
θ value	0.279714 (rank : 22)	NC score	0.040523 (rank : 116)
Query Neighborhood Hits	64	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

FES_MOUSE
θ value	0.47712 (rank : 23)	NC score	0.046996 (rank : 109)
Query Neighborhood Hits	64	Target Neighborhood Hits	980	Shared Neighborhood Hits	36
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GA2L2_MOUSE
θ value	0.47712 (rank : 24)	NC score	0.036157 (rank : 118)
Query Neighborhood Hits	64	Target Neighborhood Hits	395	Shared Neighborhood Hits	6
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

HCK_MOUSE
θ value	0.62314 (rank : 25)	NC score	0.047510 (rank : 106)
Query Neighborhood Hits	64	Target Neighborhood Hits	1029	Shared Neighborhood Hits	37
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PDK1L_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.053494 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	821	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

TRIPC_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.029158 (rank : 122)
Query Neighborhood Hits	64	Target Neighborhood Hits	319	Shared Neighborhood Hits	9
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

RIMB1_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.012668 (rank : 130)
Query Neighborhood Hits	64	Target Neighborhood Hits	1376	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ALMS1_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.029295 (rank : 121)
Query Neighborhood Hits	64	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

STK35_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.053627 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	825	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TBX2_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.013360 (rank : 129)
Query Neighborhood Hits	64	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

CDK5_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.048825 (rank : 104)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	37
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	3.0926 (rank : 33)	NC score	0.048817 (rank : 105)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	37
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CSKI2_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.008318 (rank : 135)
Query Neighborhood Hits	64	Target Neighborhood Hits	747	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

IGLL1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.019203 (rank : 125)
Query Neighborhood Hits	64	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	P20764, Q5W1K3	Gene names	Igll1, Igl-5
Domain Architecture	No domain graphic available
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Ig lambda-5) (CD179b antigen).

KS6A4_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.038837 (rank : 117)
Query Neighborhood Hits	64	Target Neighborhood Hits	866	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MLL4_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.024098 (rank : 123)
Query Neighborhood Hits	64	Target Neighborhood Hits	722	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

HCK_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.045612 (rank : 113)
Query Neighborhood Hits	64	Target Neighborhood Hits	1035	Shared Neighborhood Hits	36
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ALS_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.004729 (rank : 139)
Query Neighborhood Hits	64	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

DRD4_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.002992 (rank : 141)
Query Neighborhood Hits	64	Target Neighborhood Hits	886	Shared Neighborhood Hits	3
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

SRRM2_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.032081 (rank : 120)
Query Neighborhood Hits	64	Target Neighborhood Hits	1296	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

AFF4_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.017012 (rank : 126)
Query Neighborhood Hits	64	Target Neighborhood Hits	581	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

EDD1_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.013578 (rank : 128)
Query Neighborhood Hits	64	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

FYN_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.045195 (rank : 114)
Query Neighborhood Hits	64	Target Neighborhood Hits	1078	Shared Neighborhood Hits	36
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

HN1L_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.021775 (rank : 124)
Query Neighborhood Hits	64	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

MDC1_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.013901 (rank : 127)
Query Neighborhood Hits	64	Target Neighborhood Hits	1446	Shared Neighborhood Hits	11
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

TITIN_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.033776 (rank : 119)
Query Neighborhood Hits	64	Target Neighborhood Hits	2923	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

AT2C1_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.004998 (rank : 138)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q80XR2, Q80YZ2	Gene names	Atp2c1, Pmr1
Domain Architecture	No domain graphic available
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

BMPR2_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.047189 (rank : 108)
Query Neighborhood Hits	64	Target Neighborhood Hits	736	Shared Neighborhood Hits	34
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.047356 (rank : 107)
Query Neighborhood Hits	64	Target Neighborhood Hits	738	Shared Neighborhood Hits	34
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

CEBPB_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.012078 (rank : 131)
Query Neighborhood Hits	64	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	P17676, Q96IH2, Q9H4Z5	Gene names	CEBPB, TCF5
Domain Architecture
Description	CCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF- IL6) (Transcription factor 5).

IRAK1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.050422 (rank : 96)
Query Neighborhood Hits	64	Target Neighborhood Hits	820	Shared Neighborhood Hits	34
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

KIP2_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.009334 (rank : 134)
Query Neighborhood Hits	64	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z309	Gene names	Cib2, Kip2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

LAMC3_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.003129 (rank : 140)
Query Neighborhood Hits	64	Target Neighborhood Hits	624	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LCK_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.045704 (rank : 112)
Query Neighborhood Hits	64	Target Neighborhood Hits	987	Shared Neighborhood Hits	36
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.045998 (rank : 111)
Query Neighborhood Hits	64	Target Neighborhood Hits	981	Shared Neighborhood Hits	36
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PAK3_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.061088 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	887	Shared Neighborhood Hits	37
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.061089 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	874	Shared Neighborhood Hits	37
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PHF10_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.010960 (rank : 132)
Query Neighborhood Hits	64	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

PRP4B_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.040869 (rank : 115)
Query Neighborhood Hits	64	Target Neighborhood Hits	1030	Shared Neighborhood Hits	38
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

STMN3_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.008289 (rank : 136)
Query Neighborhood Hits	64	Target Neighborhood Hits	331	Shared Neighborhood Hits	2
SwissProt Accessions	O70166	Gene names	Stmn3, Sclip
Domain Architecture
Description	Stathmin-3 (SCG10-like protein) (SCG10-related protein HiAT3) (Hippocampus abundant transcript 3).

TLE2_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.005048 (rank : 137)
Query Neighborhood Hits	64	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

TMC2_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.010828 (rank : 133)
Query Neighborhood Hits	64	Target Neighborhood Hits	149	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

WNK4_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.049506 (rank : 103)
Query Neighborhood Hits	64	Target Neighborhood Hits	961	Shared Neighborhood Hits	36
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

AL2S2_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.064300 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	727	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.065232 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	709	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

CI096_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.053200 (rank : 76)
Query Neighborhood Hits	64	Target Neighborhood Hits	821	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

M3K14_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.052163 (rank : 83)
Query Neighborhood Hits	64	Target Neighborhood Hits	887	Shared Neighborhood Hits	38
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K14_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.050173 (rank : 100)
Query Neighborhood Hits	64	Target Neighborhood Hits	889	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K2_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.050239 (rank : 98)
Query Neighborhood Hits	64	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.050558 (rank : 94)
Query Neighborhood Hits	64	Target Neighborhood Hits	885	Shared Neighborhood Hits	37
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.050321 (rank : 97)
Query Neighborhood Hits	64	Target Neighborhood Hits	876	Shared Neighborhood Hits	36
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K6_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.050025 (rank : 102)
Query Neighborhood Hits	64	Target Neighborhood Hits	889	Shared Neighborhood Hits	35
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K8_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.058534 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	807	Shared Neighborhood Hits	33
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.058276 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	815	Shared Neighborhood Hits	33
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M4K1_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.061216 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.062173 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.061520 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	850	Shared Neighborhood Hits	34
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.061428 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	843	Shared Neighborhood Hits	34
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.059748 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.058074 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	1589	Shared Neighborhood Hits	38
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.060250 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	1560	Shared Neighborhood Hits	40
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K5_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.060809 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.060762 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MINK1_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.059304 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	1477	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.059470 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	1451	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MLKL_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.052256 (rank : 82)
Query Neighborhood Hits	64	Target Neighborhood Hits	600	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.050673 (rank : 93)
Query Neighborhood Hits	64	Target Neighborhood Hits	707	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MP2K1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.054814 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.054827 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.054062 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.054418 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.053381 (rank : 74)
Query Neighborhood Hits	64	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.053197 (rank : 77)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.056008 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.056145 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.057101 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.055338 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.053149 (rank : 78)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.053402 (rank : 73)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.054995 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MYO3A_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.051652 (rank : 89)
Query Neighborhood Hits	64	Target Neighborhood Hits	1033	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.051794 (rank : 86)
Query Neighborhood Hits	64	Target Neighborhood Hits	902	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.051759 (rank : 87)
Query Neighborhood Hits	64	Target Neighborhood Hits	923	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NEK9_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.050529 (rank : 95)
Query Neighborhood Hits	64	Target Neighborhood Hits	900	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NRBP_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.051994 (rank : 85)
Query Neighborhood Hits	64	Target Neighborhood Hits	448	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.050823 (rank : 92)
Query Neighborhood Hits	64	Target Neighborhood Hits	442	Shared Neighborhood Hits	26
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.060691 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	931	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.060381 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

OXSR1_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.057975 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.058048 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	865	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.059549 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	873	Shared Neighborhood Hits	35
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.059684 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK4_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.054573 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	924	Shared Neighborhood Hits	36
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.054203 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	1098	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.054293 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	915	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.053903 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.053908 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

SLK_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.052940 (rank : 80)
Query Neighborhood Hits	64	Target Neighborhood Hits	1775	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.053296 (rank : 75)
Query Neighborhood Hits	64	Target Neighborhood Hits	1798	Shared Neighborhood Hits	38
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK10_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.052530 (rank : 81)
Query Neighborhood Hits	64	Target Neighborhood Hits	1921	Shared Neighborhood Hits	39
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.051318 (rank : 90)
Query Neighborhood Hits	64	Target Neighborhood Hits	2132	Shared Neighborhood Hits	39
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK39_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.059258 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.059186 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TAOK1_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.055226 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	1734	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.055255 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	1720	Shared Neighborhood Hits	38
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.058770 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	1172	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.057827 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	1373	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.056342 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	1494	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.056946 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	1458	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TNIK_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.058588 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	1570	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TOPK_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.051710 (rank : 88)
Query Neighborhood Hits	64	Target Neighborhood Hits	605	Shared Neighborhood Hits	33
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.051111 (rank : 91)
Query Neighborhood Hits	64	Target Neighborhood Hits	618	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TTBK1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.052056 (rank : 84)
Query Neighborhood Hits	64	Target Neighborhood Hits	1058	Shared Neighborhood Hits	36
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

WEE1B_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.058337 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.057466 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	765	Shared Neighborhood Hits	33
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.059889 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	777	Shared Neighborhood Hits	34
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.058666 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	794	Shared Neighborhood Hits	34
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WNK3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.050225 (rank : 99)
Query Neighborhood Hits	64	Target Neighborhood Hits	948	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.050064 (rank : 101)
Query Neighborhood Hits	64	Target Neighborhood Hits	1043	Shared Neighborhood Hits	38
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

YSK4_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.053061 (rank : 79)
Query Neighborhood Hits	64	Target Neighborhood Hits	921	Shared Neighborhood Hits	35
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

Hits sorted by NC score

HASP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TF76, Q5U5K3, Q96MN1, Q9BXS7	Gene names	GSG2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (H-Haspin) (Germ cell-specific gene 2 protein).

HASP_MOUSE
NC score	0.954341 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z0R0, Q99MU9, Q9JJJ4	Gene names	Gsg2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (Germ cell-specific gene 2 protein).

MYCB2_HUMAN
NC score	0.080407 (rank : 3)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	390	Shared Neighborhood Hits	12
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

STK24_MOUSE
NC score	0.079796 (rank : 4)	θ value	0.000786445 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	856	Shared Neighborhood Hits	37
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.079702 (rank : 5)	θ value	0.000602161 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	853	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

MYCB2_MOUSE
NC score	0.079563 (rank : 6)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	307	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MST4_MOUSE
NC score	0.077731 (rank : 7)	θ value	0.0113563 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	860	Shared Neighborhood Hits	37
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.077719 (rank : 8)	θ value	0.0113563 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	852	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK25_HUMAN
NC score	0.075285 (rank : 9)	θ value	0.00665767 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	853	Shared Neighborhood Hits	36
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
NC score	0.075115 (rank : 10)	θ value	0.0113563 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	851	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK4_MOUSE
NC score	0.071671 (rank : 11)	θ value	0.0193708 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	873	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.071663 (rank : 12)	θ value	0.0193708 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK3_MOUSE
NC score	0.070930 (rank : 13)	θ value	0.0736092 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	869	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK3_HUMAN
NC score	0.070533 (rank : 14)	θ value	0.163984 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	861	Shared Neighborhood Hits	36
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

AL2S2_MOUSE
NC score	0.065232 (rank : 15)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	709	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

PAK2_MOUSE
NC score	0.064673 (rank : 16)	θ value	0.125558 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	858	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

AL2S2_HUMAN
NC score	0.064300 (rank : 17)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	727	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

PAK2_HUMAN
NC score	0.064183 (rank : 18)	θ value	0.21417 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	862	Shared Neighborhood Hits	36
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

M4K1_MOUSE
NC score	0.062173 (rank : 19)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	64	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
NC score	0.061520 (rank : 20)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	64	Target Neighborhood Hits	850	Shared Neighborhood Hits	34
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
NC score	0.061428 (rank : 21)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	64	Target Neighborhood Hits	843	Shared Neighborhood Hits	34
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K1_HUMAN
NC score	0.061216 (rank : 22)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	64	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

NEK8_MOUSE
NC score	0.061188 (rank : 23)	θ value	0.279714 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PAK3_MOUSE
NC score	0.061089 (rank : 24)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	874	Shared Neighborhood Hits	37
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.061088 (rank : 25)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	887	Shared Neighborhood Hits	37
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

M4K5_HUMAN
NC score	0.060809 (rank : 26)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	64	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

NEK8_HUMAN
NC score	0.060776 (rank : 27)	θ value	0.279714 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

M4K5_MOUSE
NC score	0.060762 (rank : 28)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	64	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

NRK_HUMAN
NC score	0.060691 (rank : 29)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	64	Target Neighborhood Hits	931	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
NC score	0.060381 (rank : 30)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	64	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

M4K4_MOUSE
NC score	0.060250 (rank : 31)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	64	Target Neighborhood Hits	1560	Shared Neighborhood Hits	40
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

WEE1_HUMAN
NC score	0.059889 (rank : 32)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	64	Target Neighborhood Hits	777	Shared Neighborhood Hits	34
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

M4K3_HUMAN
NC score	0.059748 (rank : 33)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	64	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

PAK1_MOUSE
NC score	0.059684 (rank : 34)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	64	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK1_HUMAN
NC score	0.059549 (rank : 35)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	64	Target Neighborhood Hits	873	Shared Neighborhood Hits	35
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

MINK1_MOUSE
NC score	0.059470 (rank : 36)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	64	Target Neighborhood Hits	1451	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.059304 (rank : 37)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	64	Target Neighborhood Hits	1477	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PTK6_HUMAN
NC score	0.059295 (rank : 38)	θ value	0.0193708 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	1020	Shared Neighborhood Hits	37
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

STK39_HUMAN
NC score	0.059258 (rank : 39)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	64	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
NC score	0.059186 (rank : 40)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	64	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TAOK2_HUMAN
NC score	0.058770 (rank : 41)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	64	Target Neighborhood Hits	1172	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

WEE1_MOUSE
NC score	0.058666 (rank : 42)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	64	Target Neighborhood Hits	794	Shared Neighborhood Hits	34
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

TNIK_HUMAN
NC score	0.058588 (rank : 43)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	64	Target Neighborhood Hits	1570	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

M3K8_HUMAN
NC score	0.058534 (rank : 44)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	64	Target Neighborhood Hits	807	Shared Neighborhood Hits	33
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

WEE1B_HUMAN
NC score	0.058337 (rank : 45)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	64	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

PTK6_MOUSE
NC score	0.058288 (rank : 46)	θ value	0.0736092 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	1026	Shared Neighborhood Hits	36
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

M3K8_MOUSE
NC score	0.058276 (rank : 47)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	64	Target Neighborhood Hits	815	Shared Neighborhood Hits	33
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M4K4_HUMAN
NC score	0.058074 (rank : 48)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	64	Target Neighborhood Hits	1589	Shared Neighborhood Hits	38
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

OXSR1_MOUSE
NC score	0.058048 (rank : 49)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	64	Target Neighborhood Hits	865	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_HUMAN
NC score	0.057975 (rank : 50)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	64	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TAOK2_MOUSE
NC score	0.057827 (rank : 51)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	64	Target Neighborhood Hits	1373	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

WEE1B_MOUSE
NC score	0.057466 (rank : 52)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	64	Target Neighborhood Hits	765	Shared Neighborhood Hits	33
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

MP2K5_HUMAN
NC score	0.057101 (rank : 53)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	64	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

TAOK3_MOUSE
NC score	0.056946 (rank : 54)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	64	Target Neighborhood Hits	1458	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK3_HUMAN
NC score	0.056342 (rank : 55)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	64	Target Neighborhood Hits	1494	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

MP2K4_MOUSE
NC score	0.056145 (rank : 56)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	64	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K4_HUMAN
NC score	0.056008 (rank : 57)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	64	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K5_MOUSE
NC score	0.055338 (rank : 58)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	64	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

TAOK1_MOUSE
NC score	0.055255 (rank : 59)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	64	Target Neighborhood Hits	1720	Shared Neighborhood Hits	38
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.055226 (rank : 60)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	64	Target Neighborhood Hits	1734	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

MP2K7_HUMAN
NC score	0.054995 (rank : 61)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	64	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MP2K1_MOUSE
NC score	0.054827 (rank : 62)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_HUMAN
NC score	0.054814 (rank : 63)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PAK4_HUMAN
NC score	0.054573 (rank : 64)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	64	Target Neighborhood Hits	924	Shared Neighborhood Hits	36
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MP2K2_MOUSE
NC score	0.054418 (rank : 65)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	64	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PAK6_HUMAN
NC score	0.054293 (rank : 66)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	64	Target Neighborhood Hits	915	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK4_MOUSE
NC score	0.054203 (rank : 67)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	64	Target Neighborhood Hits	1098	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MP2K2_HUMAN
NC score	0.054062 (rank : 68)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PAK7_MOUSE
NC score	0.053908 (rank : 69)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	64	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK7_HUMAN
NC score	0.053903 (rank : 70)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	64	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

STK35_HUMAN
NC score	0.053627 (rank : 71)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	825	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

PDK1L_HUMAN
NC score	0.053494 (rank : 72)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	821	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

MP2K6_MOUSE
NC score	0.053402 (rank : 73)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K3_HUMAN
NC score	0.053381 (rank : 74)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	64	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

SLK_MOUSE
NC score	0.053296 (rank : 75)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	64	Target Neighborhood Hits	1798	Shared Neighborhood Hits	38
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

CI096_HUMAN
NC score	0.053200 (rank : 76)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	821	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

MP2K3_MOUSE
NC score	0.053197 (rank : 77)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K6_HUMAN
NC score	0.053149 (rank : 78)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	64	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

YSK4_HUMAN
NC score	0.053061 (rank : 79)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	64	Target Neighborhood Hits	921	Shared Neighborhood Hits	35
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

SLK_HUMAN
NC score	0.052940 (rank : 80)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	64	Target Neighborhood Hits	1775	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK10_HUMAN
NC score	0.052530 (rank : 81)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	64	Target Neighborhood Hits	1921	Shared Neighborhood Hits	39
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MLKL_HUMAN
NC score	0.052256 (rank : 82)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	64	Target Neighborhood Hits	600	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

M3K14_HUMAN
NC score	0.052163 (rank : 83)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	887	Shared Neighborhood Hits	38
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

TTBK1_HUMAN
NC score	0.052056 (rank : 84)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	64	Target Neighborhood Hits	1058	Shared Neighborhood Hits	36
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

NRBP_HUMAN
NC score	0.051994 (rank : 85)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	64	Target Neighborhood Hits	448	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

MYO3A_MOUSE
NC score	0.051794 (rank : 86)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	64	Target Neighborhood Hits	902	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
NC score	0.051759 (rank : 87)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	64	Target Neighborhood Hits	923	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

TOPK_HUMAN
NC score	0.051710 (rank : 88)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	64	Target Neighborhood Hits	605	Shared Neighborhood Hits	33
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

MYO3A_HUMAN
NC score	0.051652 (rank : 89)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	64	Target Neighborhood Hits	1033	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

STK10_MOUSE
NC score	0.051318 (rank : 90)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	64	Target Neighborhood Hits	2132	Shared Neighborhood Hits	39
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TOPK_MOUSE
NC score	0.051111 (rank : 91)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	64	Target Neighborhood Hits	618	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

NRBP_MOUSE
NC score	0.050823 (rank : 92)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	64	Target Neighborhood Hits	442	Shared Neighborhood Hits	26
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

MLKL_MOUSE
NC score	0.050673 (rank : 93)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	64	Target Neighborhood Hits	707	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

M3K3_HUMAN
NC score	0.050558 (rank : 94)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	885	Shared Neighborhood Hits	37
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK9_HUMAN
NC score	0.050529 (rank : 95)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	64	Target Neighborhood Hits	900	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

IRAK1_HUMAN
NC score	0.050422 (rank : 96)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	820	Shared Neighborhood Hits	34
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

M3K3_MOUSE
NC score	0.050321 (rank : 97)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	876	Shared Neighborhood Hits	36
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K2_HUMAN
NC score	0.050239 (rank : 98)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

WNK3_HUMAN
NC score	0.050225 (rank : 99)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	64	Target Neighborhood Hits	948	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

M3K14_MOUSE
NC score	0.050173 (rank : 100)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	889	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

WNK4_HUMAN
NC score	0.050064 (rank : 101)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	64	Target Neighborhood Hits	1043	Shared Neighborhood Hits	38
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

M3K6_HUMAN
NC score	0.050025 (rank : 102)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	64	Target Neighborhood Hits	889	Shared Neighborhood Hits	35
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

WNK4_MOUSE
NC score	0.049506 (rank : 103)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	961	Shared Neighborhood Hits	36
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

CDK5_HUMAN
NC score	0.048825 (rank : 104)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	37
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.048817 (rank : 105)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	826	Shared Neighborhood Hits	37
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

HCK_MOUSE
NC score	0.047510 (rank : 106)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	1029	Shared Neighborhood Hits	37
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BMPR2_MOUSE
NC score	0.047356 (rank : 107)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	738	Shared Neighborhood Hits	34
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMPR2_HUMAN
NC score	0.047189 (rank : 108)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	736	Shared Neighborhood Hits	34
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

FES_MOUSE
NC score	0.046996 (rank : 109)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	980	Shared Neighborhood Hits	36
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

WDR79_HUMAN
NC score	0.046909 (rank : 110)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	246	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

LCK_MOUSE
NC score	0.045998 (rank : 111)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	981	Shared Neighborhood Hits	36
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCK_HUMAN
NC score	0.045704 (rank : 112)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	987	Shared Neighborhood Hits	36
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

HCK_HUMAN
NC score	0.045612 (rank : 113)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	1035	Shared Neighborhood Hits	36
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FYN_HUMAN
NC score	0.045195 (rank : 114)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	1078	Shared Neighborhood Hits	36
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PRP4B_HUMAN
NC score	0.040869 (rank : 115)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	1030	Shared Neighborhood Hits	38
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

SRRM2_MOUSE
NC score	0.040523 (rank : 116)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

KS6A4_MOUSE
NC score	0.038837 (rank : 117)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	866	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

GA2L2_MOUSE
NC score	0.036157 (rank : 118)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	395	Shared Neighborhood Hits	6
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

TITIN_HUMAN
NC score	0.033776 (rank : 119)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	2923	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

SRRM2_HUMAN
NC score	0.032081 (rank : 120)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	1296	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ALMS1_HUMAN
NC score	0.029295 (rank : 121)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

TRIPC_HUMAN
NC score	0.029158 (rank : 122)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	319	Shared Neighborhood Hits	9
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

MLL4_HUMAN
NC score	0.024098 (rank : 123)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	722	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

HN1L_HUMAN
NC score	0.021775 (rank : 124)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

IGLL1_MOUSE
NC score	0.019203 (rank : 125)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	P20764, Q5W1K3	Gene names	Igll1, Igl-5
Domain Architecture	No domain graphic available
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Ig lambda-5) (CD179b antigen).

AFF4_MOUSE
NC score	0.017012 (rank : 126)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	581	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

MDC1_HUMAN
NC score	0.013901 (rank : 127)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	1446	Shared Neighborhood Hits	11
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

EDD1_HUMAN
NC score	0.013578 (rank : 128)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

TBX2_HUMAN
NC score	0.013360 (rank : 129)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

RIMB1_MOUSE
NC score	0.012668 (rank : 130)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	1376	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CEBPB_HUMAN
NC score	0.012078 (rank : 131)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	P17676, Q96IH2, Q9H4Z5	Gene names	CEBPB, TCF5
Domain Architecture
Description	CCAAT/enhancer-binding protein beta (C/EBP beta) (Nuclear factor NF- IL6) (Transcription factor 5).

PHF10_HUMAN
NC score	0.010960 (rank : 132)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

TMC2_HUMAN
NC score	0.010828 (rank : 133)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	149	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

KIP2_MOUSE
NC score	0.009334 (rank : 134)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z309	Gene names	Cib2, Kip2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

CSKI2_HUMAN
NC score	0.008318 (rank : 135)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	747	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

STMN3_MOUSE
NC score	0.008289 (rank : 136)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	331	Shared Neighborhood Hits	2
SwissProt Accessions	O70166	Gene names	Stmn3, Sclip
Domain Architecture
Description	Stathmin-3 (SCG10-like protein) (SCG10-related protein HiAT3) (Hippocampus abundant transcript 3).

TLE2_MOUSE
NC score	0.005048 (rank : 137)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

AT2C1_MOUSE
NC score	0.004998 (rank : 138)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q80XR2, Q80YZ2	Gene names	Atp2c1, Pmr1
Domain Architecture	No domain graphic available
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

ALS_HUMAN
NC score	0.004729 (rank : 139)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

LAMC3_MOUSE
NC score	0.003129 (rank : 140)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	624	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

DRD4_HUMAN
NC score	0.002992 (rank : 141)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	886	Shared Neighborhood Hits	3
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).