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Network neighborhood for query Sequence : GHR_HUMAN

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GHR_HUMAN
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GHR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

GHR_MOUSE
θ value	0 (rank : 2)	NC score	0.961761 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	19
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

PRLR_HUMAN
θ value	6.37413e-38 (rank : 3)	NC score	0.694907 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	95	Shared Neighborhood Hits	28
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_MOUSE
θ value	2.67802e-36 (rank : 4)	NC score	0.695108 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

CRLF1_HUMAN
θ value	8.97725e-08 (rank : 5)	NC score	0.374188 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	122	Shared Neighborhood Hits	29
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
θ value	1.53129e-07 (rank : 6)	NC score	0.373823 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

LEPR_MOUSE
θ value	0.000158464 (rank : 7)	NC score	0.222167 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

IL27B_HUMAN
θ value	0.00228821 (rank : 8)	NC score	0.287499 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

I13R1_MOUSE
θ value	0.00869519 (rank : 9)	NC score	0.221359 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

I11RB_MOUSE
θ value	0.0193708 (rank : 10)	NC score	0.295052 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

IL6RB_HUMAN
θ value	0.0252991 (rank : 11)	NC score	0.206711 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	181	Shared Neighborhood Hits	31
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

I11RA_MOUSE
θ value	0.0330416 (rank : 12)	NC score	0.292417 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

IL27B_MOUSE
θ value	0.0431538 (rank : 13)	NC score	0.263806 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

TITIN_HUMAN
θ value	0.0431538 (rank : 14)	NC score	0.032133 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	2923	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TPOR_HUMAN
θ value	0.0431538 (rank : 15)	NC score	0.159059 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	70	Shared Neighborhood Hits	22
SwissProt Accessions	P40238	Gene names	MPL, TPOR
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

I11RA_HUMAN
θ value	0.0563607 (rank : 16)	NC score	0.274387 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	138	Shared Neighborhood Hits	24
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I12R2_MOUSE
θ value	0.0736092 (rank : 17)	NC score	0.141858 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	143	Shared Neighborhood Hits	25
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

AP3B1_MOUSE
θ value	0.125558 (rank : 18)	NC score	0.033240 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	302	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CELR2_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.008384 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	657	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

CNTFR_HUMAN
θ value	0.365318 (rank : 20)	NC score	0.238049 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	66	Shared Neighborhood Hits	19
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_MOUSE
θ value	0.365318 (rank : 21)	NC score	0.239346 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

IL6RA_MOUSE
θ value	0.365318 (rank : 22)	NC score	0.246766 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	104	Shared Neighborhood Hits	21
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

PTPRD_MOUSE
θ value	0.47712 (rank : 23)	NC score	0.033609 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	491	Shared Neighborhood Hits	22
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

TPOR_MOUSE
θ value	0.47712 (rank : 24)	NC score	0.139896 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q08351	Gene names	Mpl, Tpor
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

ELK1_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.027504 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	P19419, O75606, O95058, Q969X8, Q9UJM4	Gene names	ELK1
Domain Architecture
Description	ETS domain-containing protein Elk-1.

PTPRD_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.031186 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	485	Shared Neighborhood Hits	21
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

WBP11_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.045599 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	362	Shared Neighborhood Hits	10
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

I13R2_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.208342 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

IL5RA_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.112921 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	33	Shared Neighborhood Hits	11
SwissProt Accessions	P21183	Gene names	Il5ra, Il5r
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen).

K2027_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.033459 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWS5, Q69Z30	Gene names	Kiaa2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

ELK1_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.024446 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	P41969	Gene names	Elk1
Domain Architecture
Description	ETS domain-containing protein Elk-1.

EPHB2_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.014310 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	983	Shared Neighborhood Hits	16
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.014308 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	982	Shared Neighborhood Hits	16
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

TNPO1_MOUSE
θ value	1.81305 (rank : 34)	NC score	0.027364 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

ACINU_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.017995 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	712	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BICD1_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.007949 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	844	Shared Neighborhood Hits	6
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

EPHA4_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.013415 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	975	Shared Neighborhood Hits	14
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	3.0926 (rank : 38)	NC score	0.013383 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	982	Shared Neighborhood Hits	14
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

FES_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.007536 (rank : 71)
Query Neighborhood Hits	57	Target Neighborhood Hits	978	Shared Neighborhood Hits	10
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

IL3RB_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.061712 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	355	Shared Neighborhood Hits	19
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

LEO1_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.012884 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	958	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

TNPO1_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.024723 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

JAK1_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.007392 (rank : 72)
Query Neighborhood Hits	57	Target Neighborhood Hits	858	Shared Neighborhood Hits	10
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KLDC4_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.016912 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

TCGAP_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.008829 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	872	Shared Neighborhood Hits	8
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

APLP2_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.010000 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

I27RA_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.100987 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

ILEU_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.003629 (rank : 73)
Query Neighborhood Hits	57	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P30740, Q53FB9, Q5W0E1	Gene names	SERPINB1, ELANH2, PI2
Domain Architecture
Description	Leukocyte elastase inhibitor (LEI) (Serpin B1) (Monocyte/neutrophil elastase inhibitor) (M/NEI) (EI).

MYLK_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.008760 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	1489	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SNX1_MOUSE
θ value	6.88961 (rank : 50)	NC score	0.009925 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

WBP11_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.028903 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	354	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

CCR6_HUMAN
θ value	8.99809 (rank : 52)	NC score	-0.000023 (rank : 75)
Query Neighborhood Hits	57	Target Neighborhood Hits	650	Shared Neighborhood Hits	2
SwissProt Accessions	P51684, P78553, Q92846	Gene names	CCR6, CKRL3, CMKBR6, GPR29, STRL22
Domain Architecture
Description	C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (LARC receptor) (GPR-CY4) (GPRCY4) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (CD196 antigen).

IL3B2_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.068210 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	372	Shared Neighborhood Hits	21
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

MINT_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.008214 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	1514	Shared Neighborhood Hits	14
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PLK3_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.003492 (rank : 74)
Query Neighborhood Hits	57	Target Neighborhood Hits	865	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

RFX1_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.007703 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	256	Shared Neighborhood Hits	4
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SIDT1_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.009824 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXL6	Gene names	SIDT1
Domain Architecture	No domain graphic available
Description	SID1 transmembrane family member 1 precursor.

CSF2R_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.087800 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

CSF3R_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.142240 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	140	Shared Neighborhood Hits	20
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSF3R_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.156212 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

EPOR_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.116661 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	P19235, Q15443	Gene names	EPOR
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

EPOR_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.123883 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	P14753, Q63852	Gene names	Epor
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

I12R2_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.125714 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I13R1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.148271 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P78552, O95646, Q99656	Gene names	IL13RA1, IL13R, IL13RA
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (CD213a1 antigen).

I27RA_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.053038 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

IL12B_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.052688 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	P29460	Gene names	IL12B, NKSF2
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2).

IL12B_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.050717 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

IL3RB_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.052488 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	12
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

IL5RA_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.142479 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

IL6RA_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.216372 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

IL6RB_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.167099 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

IL7RA_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.092179 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P16871, Q6SV45, Q9UPC1	Gene names	IL7R
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen) (CDw127).

LEPR_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.184778 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

LIFR_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.106001 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

LIFR_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.091265 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

Hits sorted by NC score

GHR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

GHR_MOUSE
NC score	0.961761 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	19
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

PRLR_MOUSE
NC score	0.695108 (rank : 3)	θ value	2.67802e-36 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_HUMAN
NC score	0.694907 (rank : 4)	θ value	6.37413e-38 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	95	Shared Neighborhood Hits	28
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

CRLF1_HUMAN
NC score	0.374188 (rank : 5)	θ value	8.97725e-08 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	122	Shared Neighborhood Hits	29
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
NC score	0.373823 (rank : 6)	θ value	1.53129e-07 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

I11RB_MOUSE
NC score	0.295052 (rank : 7)	θ value	0.0193708 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

I11RA_MOUSE
NC score	0.292417 (rank : 8)	θ value	0.0330416 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

IL27B_HUMAN
NC score	0.287499 (rank : 9)	θ value	0.00228821 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

I11RA_HUMAN
NC score	0.274387 (rank : 10)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	138	Shared Neighborhood Hits	24
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

IL27B_MOUSE
NC score	0.263806 (rank : 11)	θ value	0.0431538 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

IL6RA_MOUSE
NC score	0.246766 (rank : 12)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	104	Shared Neighborhood Hits	21
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

CNTFR_MOUSE
NC score	0.239346 (rank : 13)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_HUMAN
NC score	0.238049 (rank : 14)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	66	Shared Neighborhood Hits	19
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

LEPR_MOUSE
NC score	0.222167 (rank : 15)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

I13R1_MOUSE
NC score	0.221359 (rank : 16)	θ value	0.00869519 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

IL6RA_HUMAN
NC score	0.216372 (rank : 17)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

I13R2_HUMAN
NC score	0.208342 (rank : 18)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

IL6RB_HUMAN
NC score	0.206711 (rank : 19)	θ value	0.0252991 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	181	Shared Neighborhood Hits	31
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

LEPR_HUMAN
NC score	0.184778 (rank : 20)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

IL6RB_MOUSE
NC score	0.167099 (rank : 21)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	57	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

TPOR_HUMAN
NC score	0.159059 (rank : 22)	θ value	0.0431538 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	70	Shared Neighborhood Hits	22
SwissProt Accessions	P40238	Gene names	MPL, TPOR
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

CSF3R_MOUSE
NC score	0.156212 (rank : 23)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

I13R1_HUMAN
NC score	0.148271 (rank : 24)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P78552, O95646, Q99656	Gene names	IL13RA1, IL13R, IL13RA
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (CD213a1 antigen).

IL5RA_HUMAN
NC score	0.142479 (rank : 25)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

CSF3R_HUMAN
NC score	0.142240 (rank : 26)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	140	Shared Neighborhood Hits	20
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

I12R2_MOUSE
NC score	0.141858 (rank : 27)	θ value	0.0736092 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	143	Shared Neighborhood Hits	25
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

TPOR_MOUSE
NC score	0.139896 (rank : 28)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q08351	Gene names	Mpl, Tpor
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

I12R2_HUMAN
NC score	0.125714 (rank : 29)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

EPOR_MOUSE
NC score	0.123883 (rank : 30)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	P14753, Q63852	Gene names	Epor
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

EPOR_HUMAN
NC score	0.116661 (rank : 31)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	P19235, Q15443	Gene names	EPOR
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

IL5RA_MOUSE
NC score	0.112921 (rank : 32)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	33	Shared Neighborhood Hits	11
SwissProt Accessions	P21183	Gene names	Il5ra, Il5r
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen).

LIFR_HUMAN
NC score	0.106001 (rank : 33)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	57	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

I27RA_MOUSE
NC score	0.100987 (rank : 34)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

IL7RA_HUMAN
NC score	0.092179 (rank : 35)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	57	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P16871, Q6SV45, Q9UPC1	Gene names	IL7R
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen) (CDw127).

LIFR_MOUSE
NC score	0.091265 (rank : 36)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	57	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

CSF2R_HUMAN
NC score	0.087800 (rank : 37)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

IL3B2_MOUSE
NC score	0.068210 (rank : 38)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	372	Shared Neighborhood Hits	21
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

IL3RB_MOUSE
NC score	0.061712 (rank : 39)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	355	Shared Neighborhood Hits	19
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

I27RA_HUMAN
NC score	0.053038 (rank : 40)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

IL12B_HUMAN
NC score	0.052688 (rank : 41)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	P29460	Gene names	IL12B, NKSF2
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2).

IL3RB_HUMAN
NC score	0.052488 (rank : 42)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	12
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

IL12B_MOUSE
NC score	0.050717 (rank : 43)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

WBP11_MOUSE
NC score	0.045599 (rank : 44)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	362	Shared Neighborhood Hits	10
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

PTPRD_MOUSE
NC score	0.033609 (rank : 45)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	491	Shared Neighborhood Hits	22
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

K2027_MOUSE
NC score	0.033459 (rank : 46)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWS5, Q69Z30	Gene names	Kiaa2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

AP3B1_MOUSE
NC score	0.033240 (rank : 47)	θ value	0.125558 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	302	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

TITIN_HUMAN
NC score	0.032133 (rank : 48)	θ value	0.0431538 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	2923	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

PTPRD_HUMAN
NC score	0.031186 (rank : 49)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	485	Shared Neighborhood Hits	21
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

WBP11_HUMAN
NC score	0.028903 (rank : 50)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	354	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

ELK1_HUMAN
NC score	0.027504 (rank : 51)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	P19419, O75606, O95058, Q969X8, Q9UJM4	Gene names	ELK1
Domain Architecture
Description	ETS domain-containing protein Elk-1.

TNPO1_MOUSE
NC score	0.027364 (rank : 52)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO1_HUMAN
NC score	0.024723 (rank : 53)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

ELK1_MOUSE
NC score	0.024446 (rank : 54)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	P41969	Gene names	Elk1
Domain Architecture
Description	ETS domain-containing protein Elk-1.

ACINU_MOUSE
NC score	0.017995 (rank : 55)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	712	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

KLDC4_MOUSE
NC score	0.016912 (rank : 56)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

EPHB2_HUMAN
NC score	0.014310 (rank : 57)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	983	Shared Neighborhood Hits	16
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.014308 (rank : 58)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	982	Shared Neighborhood Hits	16
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA4_HUMAN
NC score	0.013415 (rank : 59)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	975	Shared Neighborhood Hits	14
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.013383 (rank : 60)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	982	Shared Neighborhood Hits	14
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

LEO1_HUMAN
NC score	0.012884 (rank : 61)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	958	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

APLP2_HUMAN
NC score	0.010000 (rank : 62)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

SNX1_MOUSE
NC score	0.009925 (rank : 63)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

SIDT1_HUMAN
NC score	0.009824 (rank : 64)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXL6	Gene names	SIDT1
Domain Architecture	No domain graphic available
Description	SID1 transmembrane family member 1 precursor.

TCGAP_HUMAN
NC score	0.008829 (rank : 65)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	872	Shared Neighborhood Hits	8
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MYLK_MOUSE
NC score	0.008760 (rank : 66)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	1489	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CELR2_HUMAN
NC score	0.008384 (rank : 67)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	657	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

MINT_MOUSE
NC score	0.008214 (rank : 68)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	1514	Shared Neighborhood Hits	14
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

BICD1_HUMAN
NC score	0.007949 (rank : 69)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	844	Shared Neighborhood Hits	6
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

RFX1_HUMAN
NC score	0.007703 (rank : 70)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	256	Shared Neighborhood Hits	4
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

FES_HUMAN
NC score	0.007536 (rank : 71)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	978	Shared Neighborhood Hits	10
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

JAK1_HUMAN
NC score	0.007392 (rank : 72)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	858	Shared Neighborhood Hits	10
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ILEU_HUMAN
NC score	0.003629 (rank : 73)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P30740, Q53FB9, Q5W0E1	Gene names	SERPINB1, ELANH2, PI2
Domain Architecture
Description	Leukocyte elastase inhibitor (LEI) (Serpin B1) (Monocyte/neutrophil elastase inhibitor) (M/NEI) (EI).

PLK3_HUMAN
NC score	0.003492 (rank : 74)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	865	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

CCR6_HUMAN
NC score	-0.000023 (rank : 75)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	650	Shared Neighborhood Hits	2
SwissProt Accessions	P51684, P78553, Q92846	Gene names	CCR6, CKRL3, CMKBR6, GPR29, STRL22
Domain Architecture
Description	C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (LARC receptor) (GPR-CY4) (GPRCY4) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (CD196 antigen).