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Network neighborhood for query Sequence : EPOR_MOUSE

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EPOR_MOUSE
SwissProt Accessions	P14753, Q63852	Gene names	Epor
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EPOR_HUMAN
θ value	0 (rank : 1)	NC score	0.983404 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P19235, Q15443	Gene names	EPOR
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

EPOR_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P14753, Q63852	Gene names	Epor
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

TPOR_MOUSE
θ value	4.16044e-13 (rank : 3)	NC score	0.489189 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q08351	Gene names	Mpl, Tpor
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

IL9R_HUMAN
θ value	2.13673e-09 (rank : 4)	NC score	0.458176 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q01113, Q14634, Q8WWU1, Q96TF0	Gene names	IL9R
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

IL3RB_HUMAN
θ value	3.64472e-09 (rank : 5)	NC score	0.364340 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	163	Shared Neighborhood Hits	34
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

TPOR_HUMAN
θ value	6.21693e-09 (rank : 6)	NC score	0.451805 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	P40238	Gene names	MPL, TPOR
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

CRLF1_HUMAN
θ value	1.17247e-07 (rank : 7)	NC score	0.381096 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	122	Shared Neighborhood Hits	31
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
θ value	1.53129e-07 (rank : 8)	NC score	0.377888 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	116	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

PRLR_HUMAN
θ value	1.53129e-07 (rank : 9)	NC score	0.355824 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	95	Shared Neighborhood Hits	27
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_MOUSE
θ value	1.53129e-07 (rank : 10)	NC score	0.357364 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

IL9R_MOUSE
θ value	1.69304e-06 (rank : 11)	NC score	0.441357 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

IL21R_MOUSE
θ value	2.21117e-06 (rank : 12)	NC score	0.420355 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHX3, Q9ESM1	Gene names	Il21r, Nilr
Domain Architecture	No domain graphic available
Description	Interleukin-21 receptor precursor (IL-21R) (Novel interleukin receptor) (Lymphocyte receptor beta) (LR-beta) (Novel cytokine receptor NR8).

IL7RA_HUMAN
θ value	8.40245e-06 (rank : 13)	NC score	0.389664 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	P16871, Q6SV45, Q9UPC1	Gene names	IL7R
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen) (CDw127).

IL2RG_HUMAN
θ value	7.1131e-05 (rank : 14)	NC score	0.294570 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	P31785	Gene names	IL2RG
Domain Architecture
Description	Cytokine receptor common gamma chain precursor (Gamma-C) (Interleukin- 2 receptor gamma chain) (IL-2R gamma chain) (p64) (CD132 antigen).

IL21R_HUMAN
θ value	0.00020696 (rank : 15)	NC score	0.403971 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBE5, Q96HZ1, Q9HB91	Gene names	IL21R, NILR
Domain Architecture	No domain graphic available
Description	Interleukin-21 receptor precursor (IL-21R) (Novel interleukin receptor).

IL2RB_HUMAN
θ value	0.00020696 (rank : 16)	NC score	0.302477 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	P14784	Gene names	IL2RB
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (p75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

I13R1_MOUSE
θ value	0.000461057 (rank : 17)	NC score	0.308013 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

IL3RB_MOUSE
θ value	0.000786445 (rank : 18)	NC score	0.279947 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	355	Shared Neighborhood Hits	34
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

IL5RA_HUMAN
θ value	0.00228821 (rank : 19)	NC score	0.276213 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

IL7RA_MOUSE
θ value	0.00298849 (rank : 20)	NC score	0.319380 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	P16872	Gene names	Il7r
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen).

IL6RB_MOUSE
θ value	0.0113563 (rank : 21)	NC score	0.191381 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	168	Shared Neighborhood Hits	31
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

IL5RA_MOUSE
θ value	0.0193708 (rank : 22)	NC score	0.239484 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	P21183	Gene names	Il5ra, Il5r
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen).

CRLF2_HUMAN
θ value	0.0252991 (rank : 23)	NC score	0.256112 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HC73, Q9H5R3	Gene names	CRLF2, ILXR
Domain Architecture	No domain graphic available
Description	Cytokine receptor-like factor 2 precursor (Cytokine receptor-like 2) (CRL2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

CRLF2_MOUSE
θ value	0.0252991 (rank : 24)	NC score	0.232884 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

IL6RB_HUMAN
θ value	0.0330416 (rank : 25)	NC score	0.180560 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	181	Shared Neighborhood Hits	30
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IL2RB_MOUSE
θ value	0.0736092 (rank : 26)	NC score	0.277365 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	P16297, Q3TZT2	Gene names	Il2rb
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

LEPR_HUMAN
θ value	0.0961366 (rank : 27)	NC score	0.206729 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	112	Shared Neighborhood Hits	30
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

EPHAA_HUMAN
θ value	0.163984 (rank : 28)	NC score	0.023316 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

IL3B2_MOUSE
θ value	0.163984 (rank : 29)	NC score	0.268253 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	372	Shared Neighborhood Hits	35
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

LIFR_HUMAN
θ value	0.21417 (rank : 30)	NC score	0.140445 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

I13R2_HUMAN
θ value	0.279714 (rank : 31)	NC score	0.251094 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

IL3RA_HUMAN
θ value	0.279714 (rank : 32)	NC score	0.124108 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P26951	Gene names	IL3RA, IL3R
Domain Architecture	No domain graphic available
Description	Interleukin-3 receptor alpha chain precursor (IL-3R-alpha) (CD123 antigen).

PTPRU_HUMAN
θ value	0.813845 (rank : 33)	NC score	0.023751 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

TIE1_MOUSE
θ value	0.813845 (rank : 34)	NC score	0.016132 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	1266	Shared Neighborhood Hits	17
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ACK1_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.011175 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	1140	Shared Neighborhood Hits	12
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

LGP2_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.026115 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

TITIN_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.015008 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

IASPP_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.012678 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	688	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

EPHA8_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.016825 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	956	Shared Neighborhood Hits	19
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

SON_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.020613 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	957	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

IL4RA_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.104140 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	194	Shared Neighborhood Hits	18
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

LHX5_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.005245 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	453	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2C1	Gene names	LHX5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

EPHA3_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.018452 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	1009	Shared Neighborhood Hits	22
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

G137B_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.028788 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

LEPR_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.183266 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

EPHA8_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.016642 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	969	Shared Neighborhood Hits	19
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

SGCA_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.014366 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q16586, Q13710, Q13712	Gene names	SGCA, ADL, DAG2
Domain Architecture
Description	Alpha-sarcoglycan precursor (Alpha-SG) (Adhalin) (50 kDa dystrophin- associated glycoprotein) (50DAG) (Dystroglycan 2).

SON_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.017800 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	1568	Shared Neighborhood Hits	12
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

FNDC3_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.018833 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	196	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

GP152_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.003973 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

S12A6_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.005703 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

SMRC2_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.009733 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	499	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

CNTFR_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.097829 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.098020 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	13
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CSF2R_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.116565 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

CSF2R_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.057454 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q00941	Gene names	Csf2ra, Csfgmra
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen).

CSF3R_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.107709 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	140	Shared Neighborhood Hits	19
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSF3R_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.112198 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

GHR_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.123883 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	57	Shared Neighborhood Hits	14
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

GHR_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.089911 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

I11RA_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.081314 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I11RA_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.082812 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

I11RB_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.082619 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	101	Shared Neighborhood Hits	13
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

I12R2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.107395 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I12R2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.101515 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I13R1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.212308 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P78552, O95646, Q99656	Gene names	IL13RA1, IL13R, IL13RA
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (CD213a1 antigen).

I27RA_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.088698 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

IL27B_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.073238 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

IL27B_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.080880 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

IL2RG_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.244308 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	P34902	Gene names	Il2rg
Domain Architecture
Description	Cytokine receptor common gamma chain precursor (Gamma-C) (Interleukin- 2 receptor gamma chain) (IL-2R gamma chain) (p64) (CD132 antigen).

IL4RA_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.093979 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	144	Shared Neighborhood Hits	17
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

IL6RA_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.088703 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

IL6RA_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.085822 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

LIFR_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.087479 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

Hits sorted by NC score

EPOR_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P14753, Q63852	Gene names	Epor
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

EPOR_HUMAN
NC score	0.983404 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P19235, Q15443	Gene names	EPOR
Domain Architecture
Description	Erythropoietin receptor precursor (EPO-R).

TPOR_MOUSE
NC score	0.489189 (rank : 3)	θ value	4.16044e-13 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q08351	Gene names	Mpl, Tpor
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

IL9R_HUMAN
NC score	0.458176 (rank : 4)	θ value	2.13673e-09 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q01113, Q14634, Q8WWU1, Q96TF0	Gene names	IL9R
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

TPOR_HUMAN
NC score	0.451805 (rank : 5)	θ value	6.21693e-09 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	P40238	Gene names	MPL, TPOR
Domain Architecture
Description	Thrombopoietin receptor precursor (TPO-R) (Myeloproliferative leukemia protein) (C-mpl) (CD110 antigen).

IL9R_MOUSE
NC score	0.441357 (rank : 6)	θ value	1.69304e-06 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

IL21R_MOUSE
NC score	0.420355 (rank : 7)	θ value	2.21117e-06 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHX3, Q9ESM1	Gene names	Il21r, Nilr
Domain Architecture	No domain graphic available
Description	Interleukin-21 receptor precursor (IL-21R) (Novel interleukin receptor) (Lymphocyte receptor beta) (LR-beta) (Novel cytokine receptor NR8).

IL21R_HUMAN
NC score	0.403971 (rank : 8)	θ value	0.00020696 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBE5, Q96HZ1, Q9HB91	Gene names	IL21R, NILR
Domain Architecture	No domain graphic available
Description	Interleukin-21 receptor precursor (IL-21R) (Novel interleukin receptor).

IL7RA_HUMAN
NC score	0.389664 (rank : 9)	θ value	8.40245e-06 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	P16871, Q6SV45, Q9UPC1	Gene names	IL7R
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen) (CDw127).

CRLF1_HUMAN
NC score	0.381096 (rank : 10)	θ value	1.17247e-07 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	122	Shared Neighborhood Hits	31
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
NC score	0.377888 (rank : 11)	θ value	1.53129e-07 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	116	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

IL3RB_HUMAN
NC score	0.364340 (rank : 12)	θ value	3.64472e-09 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	163	Shared Neighborhood Hits	34
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

PRLR_MOUSE
NC score	0.357364 (rank : 13)	θ value	1.53129e-07 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_HUMAN
NC score	0.355824 (rank : 14)	θ value	1.53129e-07 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	95	Shared Neighborhood Hits	27
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

IL7RA_MOUSE
NC score	0.319380 (rank : 15)	θ value	0.00298849 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	P16872	Gene names	Il7r
Domain Architecture
Description	Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen).

I13R1_MOUSE
NC score	0.308013 (rank : 16)	θ value	0.000461057 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

IL2RB_HUMAN
NC score	0.302477 (rank : 17)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	P14784	Gene names	IL2RB
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (p75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

IL2RG_HUMAN
NC score	0.294570 (rank : 18)	θ value	7.1131e-05 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	P31785	Gene names	IL2RG
Domain Architecture
Description	Cytokine receptor common gamma chain precursor (Gamma-C) (Interleukin- 2 receptor gamma chain) (IL-2R gamma chain) (p64) (CD132 antigen).

IL3RB_MOUSE
NC score	0.279947 (rank : 19)	θ value	0.000786445 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	355	Shared Neighborhood Hits	34
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

IL2RB_MOUSE
NC score	0.277365 (rank : 20)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	P16297, Q3TZT2	Gene names	Il2rb
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

IL5RA_HUMAN
NC score	0.276213 (rank : 21)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

IL3B2_MOUSE
NC score	0.268253 (rank : 22)	θ value	0.163984 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	372	Shared Neighborhood Hits	35
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

CRLF2_HUMAN
NC score	0.256112 (rank : 23)	θ value	0.0252991 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HC73, Q9H5R3	Gene names	CRLF2, ILXR
Domain Architecture	No domain graphic available
Description	Cytokine receptor-like factor 2 precursor (Cytokine receptor-like 2) (CRL2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

I13R2_HUMAN
NC score	0.251094 (rank : 24)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

IL2RG_MOUSE
NC score	0.244308 (rank : 25)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	P34902	Gene names	Il2rg
Domain Architecture
Description	Cytokine receptor common gamma chain precursor (Gamma-C) (Interleukin- 2 receptor gamma chain) (IL-2R gamma chain) (p64) (CD132 antigen).

IL5RA_MOUSE
NC score	0.239484 (rank : 26)	θ value	0.0193708 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	P21183	Gene names	Il5ra, Il5r
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen).

CRLF2_MOUSE
NC score	0.232884 (rank : 27)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

I13R1_HUMAN
NC score	0.212308 (rank : 28)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P78552, O95646, Q99656	Gene names	IL13RA1, IL13R, IL13RA
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (CD213a1 antigen).

LEPR_HUMAN
NC score	0.206729 (rank : 29)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	112	Shared Neighborhood Hits	30
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

IL6RB_MOUSE
NC score	0.191381 (rank : 30)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	168	Shared Neighborhood Hits	31
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

LEPR_MOUSE
NC score	0.183266 (rank : 31)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

IL6RB_HUMAN
NC score	0.180560 (rank : 32)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	181	Shared Neighborhood Hits	30
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

LIFR_HUMAN
NC score	0.140445 (rank : 33)	θ value	0.21417 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

IL3RA_HUMAN
NC score	0.124108 (rank : 34)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P26951	Gene names	IL3RA, IL3R
Domain Architecture	No domain graphic available
Description	Interleukin-3 receptor alpha chain precursor (IL-3R-alpha) (CD123 antigen).

GHR_HUMAN
NC score	0.123883 (rank : 35)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	57	Shared Neighborhood Hits	14
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

CSF2R_HUMAN
NC score	0.116565 (rank : 36)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

CSF3R_MOUSE
NC score	0.112198 (rank : 37)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSF3R_HUMAN
NC score	0.107709 (rank : 38)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	140	Shared Neighborhood Hits	19
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

I12R2_HUMAN
NC score	0.107395 (rank : 39)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

IL4RA_MOUSE
NC score	0.104140 (rank : 40)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	194	Shared Neighborhood Hits	18
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

I12R2_MOUSE
NC score	0.101515 (rank : 41)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

CNTFR_MOUSE
NC score	0.098020 (rank : 42)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	13
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_HUMAN
NC score	0.097829 (rank : 43)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

IL4RA_HUMAN
NC score	0.093979 (rank : 44)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	144	Shared Neighborhood Hits	17
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

GHR_MOUSE
NC score	0.089911 (rank : 45)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

IL6RA_HUMAN
NC score	0.088703 (rank : 46)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

I27RA_MOUSE
NC score	0.088698 (rank : 47)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

LIFR_MOUSE
NC score	0.087479 (rank : 48)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

IL6RA_MOUSE
NC score	0.085822 (rank : 49)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

I11RA_MOUSE
NC score	0.082812 (rank : 50)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

I11RB_MOUSE
NC score	0.082619 (rank : 51)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	101	Shared Neighborhood Hits	13
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

I11RA_HUMAN
NC score	0.081314 (rank : 52)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

IL27B_MOUSE
NC score	0.080880 (rank : 53)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

IL27B_HUMAN
NC score	0.073238 (rank : 54)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

CSF2R_MOUSE
NC score	0.057454 (rank : 55)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q00941	Gene names	Csf2ra, Csfgmra
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen).

G137B_HUMAN
NC score	0.028788 (rank : 56)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

LGP2_HUMAN
NC score	0.026115 (rank : 57)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

PTPRU_HUMAN
NC score	0.023751 (rank : 58)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

EPHAA_HUMAN
NC score	0.023316 (rank : 59)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

SON_MOUSE
NC score	0.020613 (rank : 60)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	957	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

FNDC3_HUMAN
NC score	0.018833 (rank : 61)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	196	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

EPHA3_MOUSE
NC score	0.018452 (rank : 62)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	1009	Shared Neighborhood Hits	22
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

SON_HUMAN
NC score	0.017800 (rank : 63)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	1568	Shared Neighborhood Hits	12
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

EPHA8_HUMAN
NC score	0.016825 (rank : 64)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	956	Shared Neighborhood Hits	19
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
NC score	0.016642 (rank : 65)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	969	Shared Neighborhood Hits	19
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

TIE1_MOUSE
NC score	0.016132 (rank : 66)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	1266	Shared Neighborhood Hits	17
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TITIN_HUMAN
NC score	0.015008 (rank : 67)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

SGCA_HUMAN
NC score	0.014366 (rank : 68)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q16586, Q13710, Q13712	Gene names	SGCA, ADL, DAG2
Domain Architecture
Description	Alpha-sarcoglycan precursor (Alpha-SG) (Adhalin) (50 kDa dystrophin- associated glycoprotein) (50DAG) (Dystroglycan 2).

IASPP_HUMAN
NC score	0.012678 (rank : 69)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	688	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ACK1_HUMAN
NC score	0.011175 (rank : 70)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	1140	Shared Neighborhood Hits	12
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

SMRC2_HUMAN
NC score	0.009733 (rank : 71)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	499	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

S12A6_MOUSE
NC score	0.005703 (rank : 72)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

LHX5_HUMAN
NC score	0.005245 (rank : 73)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	453	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2C1	Gene names	LHX5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

GP152_HUMAN
NC score	0.003973 (rank : 74)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).