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Network neighborhood for query Sequence : E2F3_HUMAN

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E2F3_HUMAN
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

E2F3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

E2F3_MOUSE
θ value	0 (rank : 2)	NC score	0.996131 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

E2F2_MOUSE
θ value	1.49618e-87 (rank : 3)	NC score	0.969453 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

E2F2_HUMAN
θ value	1.65806e-78 (rank : 4)	NC score	0.962386 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

E2F1_HUMAN
θ value	4.83544e-70 (rank : 5)	NC score	0.961028 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

E2F1_MOUSE
θ value	4.68348e-65 (rank : 6)	NC score	0.958456 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

E2F6_MOUSE
θ value	2.3352e-48 (rank : 7)	NC score	0.940398 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	O54917	Gene names	E2f6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA).

E2F6_HUMAN
θ value	3.37202e-47 (rank : 8)	NC score	0.942494 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	O75461, O60544, Q7Z2H6	Gene names	E2F6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6).

E2F4_HUMAN
θ value	1.01765e-35 (rank : 9)	NC score	0.862133 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q16254, Q12991, Q15328	Gene names	E2F4
Domain Architecture
Description	Transcription factor E2F4 (E2F-4).

E2F5_HUMAN
θ value	3.27365e-34 (rank : 10)	NC score	0.879231 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q15329, Q16601, Q92756	Gene names	E2F5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

E2F5_MOUSE
θ value	6.17384e-33 (rank : 11)	NC score	0.877916 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q61502	Gene names	E2f5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

BAP1_MOUSE
θ value	0.0148317 (rank : 12)	NC score	0.046953 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

TDP1_HUMAN
θ value	0.0148317 (rank : 13)	NC score	0.198624 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q14186, Q8IZL5	Gene names	TFDP1, DP1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1) (DRTF1).

TDP1_MOUSE
θ value	0.0148317 (rank : 14)	NC score	0.200992 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q08639	Gene names	Tfdp1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1).

TDP2_HUMAN
θ value	0.0736092 (rank : 15)	NC score	0.158784 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q14188, Q13331, Q14187, Q6R754, Q8WU88	Gene names	TFDP2, DP2
Domain Architecture
Description	Transcription factor Dp-2 (E2F dimerization partner 2).

CO5A3_HUMAN
θ value	0.365318 (rank : 16)	NC score	0.012462 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	433	Shared Neighborhood Hits	4
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

TS13_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.059266 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

BLM_MOUSE
θ value	0.62314 (rank : 18)	NC score	0.017623 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

CJ118_MOUSE
θ value	0.62314 (rank : 19)	NC score	0.011664 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	1132	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

KIF4A_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.010705 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	1159	Shared Neighborhood Hits	12
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MKL2_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.036062 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	269	Shared Neighborhood Hits	5
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

DESP_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.010839 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	1470	Shared Neighborhood Hits	12
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

KNTC2_MOUSE
θ value	1.38821 (rank : 23)	NC score	0.021481 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	692	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

GOGA1_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.011176 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	1222	Shared Neighborhood Hits	10
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MCR_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.016078 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

PRKDC_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.021059 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

HIC2_HUMAN
θ value	2.36792 (rank : 27)	NC score	-0.000236 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	820	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).

CO4A2_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.006857 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

MCR_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.014606 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

NRX2A_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.014422 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	614	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

HCN1_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.006175 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

PCSK7_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.010799 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

CP250_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.005729 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	1583	Shared Neighborhood Hits	10
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MKL2_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.025945 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

NRX3A_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.012973 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	164	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4C0, O95378, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486	Gene names	NRXN3, KIAA0743
Domain Architecture
Description	Neurexin-3-alpha precursor (Neurexin III-alpha).

CI093_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.009363 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	1088	Shared Neighborhood Hits	11
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

DLGP2_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.014428 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

DLGP4_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.011771 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

EGFL7_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.004960 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	287	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXT5, Q6XD35, Q9DCP5	Gene names	Egfl7, Megf7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (Zneu1).

GOGA3_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.006556 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1437	Shared Neighborhood Hits	10
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

KCNT1_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.013941 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JUK3, Q9P2C5	Gene names	KCNT1, KIAA1422
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily T member 1 (KCa4.1).

KAISO_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.001360 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	840	Shared Neighborhood Hits	5
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

SHE_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.010238 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ZN668_HUMAN
θ value	8.99809 (rank : 44)	NC score	-0.002001 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q96K58, Q59EV1, Q8N669, Q9H8L4	Gene names	ZNF668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

TDP2_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.062981 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q64163	Gene names	Tfdp2, Dp2
Domain Architecture
Description	Transcription factor Dp-2 (E2F dimerization partner 2) (Dp-3).

Hits sorted by NC score

E2F3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

E2F3_MOUSE
NC score	0.996131 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

E2F2_MOUSE
NC score	0.969453 (rank : 3)	θ value	1.49618e-87 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

E2F2_HUMAN
NC score	0.962386 (rank : 4)	θ value	1.65806e-78 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

E2F1_HUMAN
NC score	0.961028 (rank : 5)	θ value	4.83544e-70 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

E2F1_MOUSE
NC score	0.958456 (rank : 6)	θ value	4.68348e-65 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

E2F6_HUMAN
NC score	0.942494 (rank : 7)	θ value	3.37202e-47 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	O75461, O60544, Q7Z2H6	Gene names	E2F6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6).

E2F6_MOUSE
NC score	0.940398 (rank : 8)	θ value	2.3352e-48 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	O54917	Gene names	E2f6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA).

E2F5_HUMAN
NC score	0.879231 (rank : 9)	θ value	3.27365e-34 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q15329, Q16601, Q92756	Gene names	E2F5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

E2F5_MOUSE
NC score	0.877916 (rank : 10)	θ value	6.17384e-33 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q61502	Gene names	E2f5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

E2F4_HUMAN
NC score	0.862133 (rank : 11)	θ value	1.01765e-35 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q16254, Q12991, Q15328	Gene names	E2F4
Domain Architecture
Description	Transcription factor E2F4 (E2F-4).

TDP1_MOUSE
NC score	0.200992 (rank : 12)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q08639	Gene names	Tfdp1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1).

TDP1_HUMAN
NC score	0.198624 (rank : 13)	θ value	0.0148317 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q14186, Q8IZL5	Gene names	TFDP1, DP1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1) (DRTF1).

TDP2_HUMAN
NC score	0.158784 (rank : 14)	θ value	0.0736092 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q14188, Q13331, Q14187, Q6R754, Q8WU88	Gene names	TFDP2, DP2
Domain Architecture
Description	Transcription factor Dp-2 (E2F dimerization partner 2).

TDP2_MOUSE
NC score	0.062981 (rank : 15)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q64163	Gene names	Tfdp2, Dp2
Domain Architecture
Description	Transcription factor Dp-2 (E2F dimerization partner 2) (Dp-3).

TS13_MOUSE
NC score	0.059266 (rank : 16)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

BAP1_MOUSE
NC score	0.046953 (rank : 17)	θ value	0.0148317 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

MKL2_MOUSE
NC score	0.036062 (rank : 18)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	269	Shared Neighborhood Hits	5
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

MKL2_HUMAN
NC score	0.025945 (rank : 19)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

KNTC2_MOUSE
NC score	0.021481 (rank : 20)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	692	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

PRKDC_HUMAN
NC score	0.021059 (rank : 21)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

BLM_MOUSE
NC score	0.017623 (rank : 22)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

MCR_HUMAN
NC score	0.016078 (rank : 23)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

MCR_MOUSE
NC score	0.014606 (rank : 24)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

DLGP2_MOUSE
NC score	0.014428 (rank : 25)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

NRX2A_HUMAN
NC score	0.014422 (rank : 26)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	614	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

KCNT1_HUMAN
NC score	0.013941 (rank : 27)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JUK3, Q9P2C5	Gene names	KCNT1, KIAA1422
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily T member 1 (KCa4.1).

NRX3A_HUMAN
NC score	0.012973 (rank : 28)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	164	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4C0, O95378, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486	Gene names	NRXN3, KIAA0743
Domain Architecture
Description	Neurexin-3-alpha precursor (Neurexin III-alpha).

CO5A3_HUMAN
NC score	0.012462 (rank : 29)	θ value	0.365318 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	433	Shared Neighborhood Hits	4
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

DLGP4_HUMAN
NC score	0.011771 (rank : 30)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

CJ118_MOUSE
NC score	0.011664 (rank : 31)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	1132	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

GOGA1_HUMAN
NC score	0.011176 (rank : 32)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	1222	Shared Neighborhood Hits	10
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

DESP_HUMAN
NC score	0.010839 (rank : 33)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	1470	Shared Neighborhood Hits	12
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

PCSK7_MOUSE
NC score	0.010799 (rank : 34)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

KIF4A_HUMAN
NC score	0.010705 (rank : 35)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	1159	Shared Neighborhood Hits	12
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

SHE_MOUSE
NC score	0.010238 (rank : 36)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

CI093_HUMAN
NC score	0.009363 (rank : 37)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	1088	Shared Neighborhood Hits	11
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CO4A2_MOUSE
NC score	0.006857 (rank : 38)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

GOGA3_MOUSE
NC score	0.006556 (rank : 39)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	1437	Shared Neighborhood Hits	10
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

HCN1_MOUSE
NC score	0.006175 (rank : 40)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

CP250_MOUSE
NC score	0.005729 (rank : 41)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	1583	Shared Neighborhood Hits	10
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

EGFL7_MOUSE
NC score	0.004960 (rank : 42)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	287	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXT5, Q6XD35, Q9DCP5	Gene names	Egfl7, Megf7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (Zneu1).

KAISO_HUMAN
NC score	0.001360 (rank : 43)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	840	Shared Neighborhood Hits	5
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

HIC2_HUMAN
NC score	-0.000236 (rank : 44)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	820	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).

ZN668_HUMAN
NC score	-0.002001 (rank : 45)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q96K58, Q59EV1, Q8N669, Q9H8L4	Gene names	ZNF668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.