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Network neighborhood for query Sequence : SYH_HUMAN

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SYH_HUMAN
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYHH_HUMAN
θ value	0 (rank : 1)	NC score	0.990451 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

SYH_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYH_MOUSE
θ value	0 (rank : 3)	NC score	0.995396 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

E2AK4_MOUSE
θ value	1.24399e-33 (rank : 4)	NC score	0.223449 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	984	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

E2AK4_HUMAN
θ value	4.72714e-33 (rank : 5)	NC score	0.217019 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	1012	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SYM_MOUSE
θ value	0.00175202 (rank : 6)	NC score	0.160205 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYM_HUMAN
θ value	0.00509761 (rank : 7)	NC score	0.150490 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYEP_MOUSE
θ value	0.0736092 (rank : 8)	NC score	0.089349 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	123	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

LRRF1_HUMAN
θ value	0.279714 (rank : 9)	NC score	0.056340 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	625	Shared Neighborhood Hits	9
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LRRF2_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.035957 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	791	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

SYEP_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.080436 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

CP250_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.023324 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	1805	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CCD41_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.012095 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1139	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

KIF3C_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.013182 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	478	Shared Neighborhood Hits	11
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

KIF3C_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.012182 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	468	Shared Neighborhood Hits	9
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

MRP3_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.006437 (rank : 22)
Query Neighborhood Hits	19	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O15438, O60265, O60922, O75621, O95078, O95289, O95290, Q9UN52	Gene names	ABCC3, CMOAT2, MLP2, MRP3
Domain Architecture
Description	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D).

CCD39_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.005792 (rank : 23)
Query Neighborhood Hits	19	Target Neighborhood Hits	1026	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CP250_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.011389 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	1583	Shared Neighborhood Hits	13
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CTGE5_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.006836 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	928	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

RNF25_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.076765 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

RNF25_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.075292 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

RWDD1_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.070916 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H446, Q9Y313, Q9Y6B3	Gene names	RWDD1
Domain Architecture
Description	RWD domain-containing protein 1.

RWDD1_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.070594 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQK7	Gene names	Rwdd1
Domain Architecture
Description	RWD domain-containing protein 1 (IH1).

Hits sorted by NC score

SYH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYH_MOUSE
NC score	0.995396 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYHH_HUMAN
NC score	0.990451 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

E2AK4_MOUSE
NC score	0.223449 (rank : 4)	θ value	1.24399e-33 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	984	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

E2AK4_HUMAN
NC score	0.217019 (rank : 5)	θ value	4.72714e-33 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	1012	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SYM_MOUSE
NC score	0.160205 (rank : 6)	θ value	0.00175202 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYM_HUMAN
NC score	0.150490 (rank : 7)	θ value	0.00509761 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYEP_MOUSE
NC score	0.089349 (rank : 8)	θ value	0.0736092 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	123	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SYEP_HUMAN
NC score	0.080436 (rank : 9)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

RNF25_HUMAN
NC score	0.076765 (rank : 10)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

RNF25_MOUSE
NC score	0.075292 (rank : 11)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

RWDD1_HUMAN
NC score	0.070916 (rank : 12)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	19	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H446, Q9Y313, Q9Y6B3	Gene names	RWDD1
Domain Architecture
Description	RWD domain-containing protein 1.

RWDD1_MOUSE
NC score	0.070594 (rank : 13)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	19	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQK7	Gene names	Rwdd1
Domain Architecture
Description	RWD domain-containing protein 1 (IH1).

LRRF1_HUMAN
NC score	0.056340 (rank : 14)	θ value	0.279714 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	625	Shared Neighborhood Hits	9
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LRRF2_HUMAN
NC score	0.035957 (rank : 15)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	791	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

CP250_HUMAN
NC score	0.023324 (rank : 16)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	1805	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

KIF3C_HUMAN
NC score	0.013182 (rank : 17)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	478	Shared Neighborhood Hits	11
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

KIF3C_MOUSE
NC score	0.012182 (rank : 18)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	468	Shared Neighborhood Hits	9
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

CCD41_HUMAN
NC score	0.012095 (rank : 19)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	1139	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CP250_MOUSE
NC score	0.011389 (rank : 20)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	1583	Shared Neighborhood Hits	13
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CTGE5_MOUSE
NC score	0.006836 (rank : 21)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	928	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

MRP3_HUMAN
NC score	0.006437 (rank : 22)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O15438, O60265, O60922, O75621, O95078, O95289, O95290, Q9UN52	Gene names	ABCC3, CMOAT2, MLP2, MRP3
Domain Architecture
Description	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D).

CCD39_MOUSE
NC score	0.005792 (rank : 23)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	1026	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.