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Network neighborhood for query Sequence : PSN1_MOUSE

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PSN1_MOUSE
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSN1_HUMAN
θ value	0 (rank : 1)	NC score	0.997055 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN2_HUMAN
θ value	5.08302e-128 (rank : 3)	NC score	0.979278 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN2_MOUSE
θ value	3.64273e-126 (rank : 4)	NC score	0.978301 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

TR135_MOUSE
θ value	0.125558 (rank : 5)	NC score	0.063494 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQA9, Q7M705	Gene names	Tas2r135, T2r38, Tas2r35
Domain Architecture
Description	Taste receptor type 2 member 135 (T2R135) (Taste receptor type 2 member 35) (T2R35) (mT2r38).

CX3C1_MOUSE
θ value	0.365318 (rank : 6)	NC score	0.013883 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	598	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0D9	Gene names	Cx3cr1
Domain Architecture
Description	CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine receptor).

K2C4_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.006826 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	521	Shared Neighborhood Hits	2
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

NFAT5_HUMAN
θ value	0.813845 (rank : 8)	NC score	0.023755 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

S22A4_HUMAN
θ value	0.813845 (rank : 9)	NC score	0.017645 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H015, O14546	Gene names	SLC22A4, ETT, OCTN1, UT2H
Domain Architecture	No domain graphic available
Description	Organic cation/carnitine transporter 1 (Solute carrier family 22 member 4) (Ergothioneine transporter) (ET transporter).

HM13_MOUSE
θ value	1.38821 (rank : 10)	NC score	0.100374 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

HM13_HUMAN
θ value	1.81305 (rank : 11)	NC score	0.091296 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

CD47_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.045976 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q08722, Q53Y71, Q96A60	Gene names	CD47
Domain Architecture
Description	Leukocyte surface antigen CD47 precursor (Integrin-associated protein) (IAP) (Antigenic surface determinant protein OA3) (Protein MER6).

LIPE_MOUSE
θ value	2.36792 (rank : 13)	NC score	0.015234 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

CTL1_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.018480 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWI5, Q5VUB3, Q8WVB0, Q96KU3, Q9NY69	Gene names	SLC44A1, CDW92, CTL1
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD92 antigen) (CDw92).

PSL2_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.035361 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

GPR89_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.035369 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BS95, Q9D455	Gene names	Gpr89a, Gpr89
Domain Architecture	No domain graphic available
Description	Protein GPR89A.

GPR89_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.032549 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y302, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4	Gene names	GPR89A, GPR89, SH120
Domain Architecture	No domain graphic available
Description	Protein GPR89A (Putative MAPK-activating protein PM01) (Putative NF- kappa-B-activating protein 90).

O13J1_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.000362 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	821	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGT2, Q96R40	Gene names	OR13J1
Domain Architecture
Description	Olfactory receptor 13J1.

ZAR1_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.015658 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

AT11A_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.006249 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	P98196, Q5VXT2	Gene names	ATP11A, ATPIH, ATPIS, KIAA1021
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase class I type 11A) (ATPase IS).

CX3C1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.005134 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	662	Shared Neighborhood Hits	3
SwissProt Accessions	P49238	Gene names	CX3CR1, GPR13
Domain Architecture
Description	CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMKBLR1).

SCN2A_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.007236 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

Hits sorted by NC score

PSN1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_HUMAN
NC score	0.997055 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN2_HUMAN
NC score	0.979278 (rank : 3)	θ value	5.08302e-128 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN2_MOUSE
NC score	0.978301 (rank : 4)	θ value	3.64273e-126 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

HM13_MOUSE
NC score	0.100374 (rank : 5)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

HM13_HUMAN
NC score	0.091296 (rank : 6)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

TR135_MOUSE
NC score	0.063494 (rank : 7)	θ value	0.125558 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQA9, Q7M705	Gene names	Tas2r135, T2r38, Tas2r35
Domain Architecture
Description	Taste receptor type 2 member 135 (T2R135) (Taste receptor type 2 member 35) (T2R35) (mT2r38).

CD47_HUMAN
NC score	0.045976 (rank : 8)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q08722, Q53Y71, Q96A60	Gene names	CD47
Domain Architecture
Description	Leukocyte surface antigen CD47 precursor (Integrin-associated protein) (IAP) (Antigenic surface determinant protein OA3) (Protein MER6).

GPR89_MOUSE
NC score	0.035369 (rank : 9)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BS95, Q9D455	Gene names	Gpr89a, Gpr89
Domain Architecture	No domain graphic available
Description	Protein GPR89A.

PSL2_HUMAN
NC score	0.035361 (rank : 10)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

GPR89_HUMAN
NC score	0.032549 (rank : 11)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y302, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4	Gene names	GPR89A, GPR89, SH120
Domain Architecture	No domain graphic available
Description	Protein GPR89A (Putative MAPK-activating protein PM01) (Putative NF- kappa-B-activating protein 90).

NFAT5_HUMAN
NC score	0.023755 (rank : 12)	θ value	0.813845 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

CTL1_HUMAN
NC score	0.018480 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWI5, Q5VUB3, Q8WVB0, Q96KU3, Q9NY69	Gene names	SLC44A1, CDW92, CTL1
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD92 antigen) (CDw92).

S22A4_HUMAN
NC score	0.017645 (rank : 14)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H015, O14546	Gene names	SLC22A4, ETT, OCTN1, UT2H
Domain Architecture	No domain graphic available
Description	Organic cation/carnitine transporter 1 (Solute carrier family 22 member 4) (Ergothioneine transporter) (ET transporter).

ZAR1_HUMAN
NC score	0.015658 (rank : 15)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

LIPE_MOUSE
NC score	0.015234 (rank : 16)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

CX3C1_MOUSE
NC score	0.013883 (rank : 17)	θ value	0.365318 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	598	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0D9	Gene names	Cx3cr1
Domain Architecture
Description	CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine receptor).

SCN2A_HUMAN
NC score	0.007236 (rank : 18)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

K2C4_MOUSE
NC score	0.006826 (rank : 19)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	521	Shared Neighborhood Hits	2
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

AT11A_HUMAN
NC score	0.006249 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	P98196, Q5VXT2	Gene names	ATP11A, ATPIH, ATPIS, KIAA1021
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase class I type 11A) (ATPase IS).

CX3C1_HUMAN
NC score	0.005134 (rank : 21)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	662	Shared Neighborhood Hits	3
SwissProt Accessions	P49238	Gene names	CX3CR1, GPR13
Domain Architecture
Description	CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMKBLR1).

O13J1_HUMAN
NC score	0.000362 (rank : 22)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	821	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGT2, Q96R40	Gene names	OR13J1
Domain Architecture
Description	Olfactory receptor 13J1.