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Network neighborhood for query Sequence : M2GD_MOUSE

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M2GD_MOUSE
SwissProt Accessions	Q9DBT9, Q8R1S7	Gene names	Dmgdh
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

M2GD_HUMAN
θ value	0 (rank : 1)	NC score	0.998551 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UI17	Gene names	DMGDH
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

M2GD_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBT9, Q8R1S7	Gene names	Dmgdh
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

SARDH_HUMAN
θ value	2.79562e-118 (rank : 3)	NC score	0.911602 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UL12, Q9Y280, Q9Y2Y3	Gene names	SARDH
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH) (BPR-2).

SARDH_MOUSE
θ value	8.99321e-117 (rank : 4)	NC score	0.914358 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q99LB7	Gene names	Sardh
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH).

GCST_MOUSE
θ value	3.07829e-16 (rank : 5)	NC score	0.562610 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFA2	Gene names	Amt
Domain Architecture
Description	Aminomethyltransferase, mitochondrial precursor (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT).

GCST_HUMAN
θ value	2.60593e-15 (rank : 6)	NC score	0.576322 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	P48728	Gene names	AMT, GCST
Domain Architecture
Description	Aminomethyltransferase, mitochondrial precursor (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT).

SOX_HUMAN
θ value	5.62301e-10 (rank : 7)	NC score	0.366030 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P0Z9, Q96H28, Q9C070	Gene names	PIPOX, LPIPOX, PSO
Domain Architecture
Description	Peroxisomal sarcosine oxidase (EC 1.5.3.1) (PSO) (L-pipecolate oxidase) (EC 1.5.3.7) (L-pipecolic acid oxidase).

GPDM_MOUSE
θ value	6.43352e-06 (rank : 8)	NC score	0.238864 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

GPDM_HUMAN
θ value	3.19293e-05 (rank : 9)	NC score	0.197217 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

SOX_MOUSE
θ value	0.000602161 (rank : 10)	NC score	0.280033 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D826, O55223	Gene names	Pipox, Pso
Domain Architecture
Description	Peroxisomal sarcosine oxidase (EC 1.5.3.1) (PSO) (L-pipecolate oxidase) (EC 1.5.3.7) (L-pipecolic acid oxidase).

SYRM_MOUSE
θ value	0.365318 (rank : 11)	NC score	0.058676 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U186, Q8QZU7	Gene names	Rarsl, Rars2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

EXO1_HUMAN
θ value	1.81305 (rank : 12)	NC score	0.043782 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

PPOX_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.040584 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	P50336	Gene names	PPOX
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

RETST_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.043410 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NUM9, Q53R95, Q53SA9, Q6UX05, Q8N2H5, Q96FA4, Q9NXE5	Gene names	RETSAT
Domain Architecture	No domain graphic available
Description	All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).

RETST_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.044968 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q64FW2, Q3UNN9, Q78JX8, Q8VHE7, Q9CW85	Gene names	Retsat
Domain Architecture	No domain graphic available
Description	All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).

EXO1_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.036877 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QZ11, Q3TLM4, Q923A5	Gene names	Exo1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (mExo1) (Exonuclease I).

GANC_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.010178 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TET4, Q52LQ4, Q8IWZ0, Q8IZM4, Q8IZM5	Gene names	GANC
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.20).

ST14_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.002263 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	419	Shared Neighborhood Hits	2
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

SYRM_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.039882 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T160, Q96FU5, Q9H8K8	Gene names	RARSL, RARS2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

TRXR1_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.016763 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

ZN181_HUMAN
θ value	8.99809 (rank : 21)	NC score	-0.000346 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	764	Shared Neighborhood Hits	3
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

L2HDH_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.083486 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9P8, Q9BRR1	Gene names	L2HGDH, C14orf160
Domain Architecture	No domain graphic available
Description	L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.2) (Duranin).

L2HDH_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.057263 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YP0, Q3TH61, Q3U7Z0, Q3ULY6	Gene names	L2hgdh
Domain Architecture	No domain graphic available
Description	L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.2) (Duranin).

Hits sorted by NC score

M2GD_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBT9, Q8R1S7	Gene names	Dmgdh
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

M2GD_HUMAN
NC score	0.998551 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UI17	Gene names	DMGDH
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

SARDH_MOUSE
NC score	0.914358 (rank : 3)	θ value	8.99321e-117 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q99LB7	Gene names	Sardh
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH).

SARDH_HUMAN
NC score	0.911602 (rank : 4)	θ value	2.79562e-118 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UL12, Q9Y280, Q9Y2Y3	Gene names	SARDH
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH) (BPR-2).

GCST_HUMAN
NC score	0.576322 (rank : 5)	θ value	2.60593e-15 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	P48728	Gene names	AMT, GCST
Domain Architecture
Description	Aminomethyltransferase, mitochondrial precursor (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT).

GCST_MOUSE
NC score	0.562610 (rank : 6)	θ value	3.07829e-16 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFA2	Gene names	Amt
Domain Architecture
Description	Aminomethyltransferase, mitochondrial precursor (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT).

SOX_HUMAN
NC score	0.366030 (rank : 7)	θ value	5.62301e-10 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P0Z9, Q96H28, Q9C070	Gene names	PIPOX, LPIPOX, PSO
Domain Architecture
Description	Peroxisomal sarcosine oxidase (EC 1.5.3.1) (PSO) (L-pipecolate oxidase) (EC 1.5.3.7) (L-pipecolic acid oxidase).

SOX_MOUSE
NC score	0.280033 (rank : 8)	θ value	0.000602161 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D826, O55223	Gene names	Pipox, Pso
Domain Architecture
Description	Peroxisomal sarcosine oxidase (EC 1.5.3.1) (PSO) (L-pipecolate oxidase) (EC 1.5.3.7) (L-pipecolic acid oxidase).

GPDM_MOUSE
NC score	0.238864 (rank : 9)	θ value	6.43352e-06 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

GPDM_HUMAN
NC score	0.197217 (rank : 10)	θ value	3.19293e-05 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

L2HDH_HUMAN
NC score	0.083486 (rank : 11)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9P8, Q9BRR1	Gene names	L2HGDH, C14orf160
Domain Architecture	No domain graphic available
Description	L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.2) (Duranin).

SYRM_MOUSE
NC score	0.058676 (rank : 12)	θ value	0.365318 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U186, Q8QZU7	Gene names	Rarsl, Rars2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

L2HDH_MOUSE
NC score	0.057263 (rank : 13)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YP0, Q3TH61, Q3U7Z0, Q3ULY6	Gene names	L2hgdh
Domain Architecture	No domain graphic available
Description	L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.2) (Duranin).

RETST_MOUSE
NC score	0.044968 (rank : 14)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q64FW2, Q3UNN9, Q78JX8, Q8VHE7, Q9CW85	Gene names	Retsat
Domain Architecture	No domain graphic available
Description	All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).

EXO1_HUMAN
NC score	0.043782 (rank : 15)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

RETST_HUMAN
NC score	0.043410 (rank : 16)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NUM9, Q53R95, Q53SA9, Q6UX05, Q8N2H5, Q96FA4, Q9NXE5	Gene names	RETSAT
Domain Architecture	No domain graphic available
Description	All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).

PPOX_HUMAN
NC score	0.040584 (rank : 17)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	P50336	Gene names	PPOX
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

SYRM_HUMAN
NC score	0.039882 (rank : 18)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T160, Q96FU5, Q9H8K8	Gene names	RARSL, RARS2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

EXO1_MOUSE
NC score	0.036877 (rank : 19)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QZ11, Q3TLM4, Q923A5	Gene names	Exo1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (mExo1) (Exonuclease I).

TRXR1_HUMAN
NC score	0.016763 (rank : 20)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

GANC_HUMAN
NC score	0.010178 (rank : 21)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TET4, Q52LQ4, Q8IWZ0, Q8IZM4, Q8IZM5	Gene names	GANC
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.20).

ST14_MOUSE
NC score	0.002263 (rank : 22)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	419	Shared Neighborhood Hits	2
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

ZN181_HUMAN
NC score	-0.000346 (rank : 23)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	764	Shared Neighborhood Hits	3
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).