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Network neighborhood for query Sequence : AREG_MOUSE

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AREG_MOUSE
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AREG_MOUSE
θ value	2.91321e-91 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

AREG_HUMAN
θ value	1.90589e-58 (rank : 2)	NC score	0.976684 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	32
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

HBEGF_HUMAN
θ value	1.80886e-08 (rank : 3)	NC score	0.613821 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	24
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

HBEGF_MOUSE
θ value	9.92553e-07 (rank : 4)	NC score	0.598697 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

TEFF2_HUMAN
θ value	1.87187e-05 (rank : 5)	NC score	0.407038 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	211	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
θ value	1.87187e-05 (rank : 6)	NC score	0.408091 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

BTC_MOUSE
θ value	3.19293e-05 (rank : 7)	NC score	0.545636 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EGF_HUMAN
θ value	0.000158464 (rank : 8)	NC score	0.152454 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	343	Shared Neighborhood Hits	32
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EREG_HUMAN
θ value	0.000158464 (rank : 9)	NC score	0.509145 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	73	Shared Neighborhood Hits	28
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

EREG_MOUSE
θ value	0.00020696 (rank : 10)	NC score	0.517543 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	65	Shared Neighborhood Hits	26
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

EPGN_MOUSE
θ value	0.000270298 (rank : 11)	NC score	0.521760 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EPGN_HUMAN
θ value	0.000786445 (rank : 12)	NC score	0.514242 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	59	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

BTC_HUMAN
θ value	0.00134147 (rank : 13)	NC score	0.510150 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	70	Shared Neighborhood Hits	27
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

TGFA_HUMAN
θ value	0.00228821 (rank : 14)	NC score	0.480386 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	26
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TGFA_MOUSE
θ value	0.00298849 (rank : 15)	NC score	0.485591 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	26
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

EGF_MOUSE
θ value	0.00390308 (rank : 16)	NC score	0.140156 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

NRG2_HUMAN
θ value	0.00665767 (rank : 17)	NC score	0.214467 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG4_HUMAN
θ value	0.0148317 (rank : 18)	NC score	0.407444 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

LYAM2_MOUSE
θ value	0.0330416 (rank : 19)	NC score	0.074081 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	420	Shared Neighborhood Hits	20
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

NRG2_MOUSE
θ value	0.0431538 (rank : 20)	NC score	0.217250 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

LYAM1_HUMAN
θ value	0.21417 (rank : 21)	NC score	0.088418 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	315	Shared Neighborhood Hits	18
SwissProt Accessions	P14151, P15023	Gene names	SELL, LNHR, LYAM1
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (TQ1) (gp90-MEL) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

SIM1_MOUSE
θ value	0.365318 (rank : 22)	NC score	0.040441 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NRG4_MOUSE
θ value	0.47712 (rank : 23)	NC score	0.358328 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	79	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

DNER_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.060379 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

RPTN_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.018000 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	650	Shared Neighborhood Hits	2
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

LYAM1_MOUSE
θ value	1.81305 (rank : 26)	NC score	0.069360 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	332	Shared Neighborhood Hits	14
SwissProt Accessions	P18337	Gene names	Sell, Lnhr, Ly-22
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

TSP2_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.035704 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	359	Shared Neighborhood Hits	12
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

DNER_MOUSE
θ value	2.36792 (rank : 28)	NC score	0.057439 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	413	Shared Neighborhood Hits	29
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

NRG3_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.168159 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	119	Shared Neighborhood Hits	25
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

NRG3_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.172184 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

SIM1_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.035724 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

FATH_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.028265 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

SAMD9_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.040051 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

SLIT3_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.040182 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	700	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

TBL1X_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.011832 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	329	Shared Neighborhood Hits	3
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

HABP2_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.019728 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TBLX_MOUSE
θ value	5.27518 (rank : 37)	NC score	0.011056 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).

CUBN_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.038204 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	477	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SMDF_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.157046 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	117	Shared Neighborhood Hits	25
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

CJ012_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.014916 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	467	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

LYAM2_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.056262 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

NRG1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.203458 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	285	Shared Neighborhood Hits	28
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

Hits sorted by NC score

AREG_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.91321e-91 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

AREG_HUMAN
NC score	0.976684 (rank : 2)	θ value	1.90589e-58 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	32
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

HBEGF_HUMAN
NC score	0.613821 (rank : 3)	θ value	1.80886e-08 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	24
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

HBEGF_MOUSE
NC score	0.598697 (rank : 4)	θ value	9.92553e-07 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

BTC_MOUSE
NC score	0.545636 (rank : 5)	θ value	3.19293e-05 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EPGN_MOUSE
NC score	0.521760 (rank : 6)	θ value	0.000270298 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EREG_MOUSE
NC score	0.517543 (rank : 7)	θ value	0.00020696 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	65	Shared Neighborhood Hits	26
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

EPGN_HUMAN
NC score	0.514242 (rank : 8)	θ value	0.000786445 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	59	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

BTC_HUMAN
NC score	0.510150 (rank : 9)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	70	Shared Neighborhood Hits	27
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EREG_HUMAN
NC score	0.509145 (rank : 10)	θ value	0.000158464 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	73	Shared Neighborhood Hits	28
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

TGFA_MOUSE
NC score	0.485591 (rank : 11)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	26
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TGFA_HUMAN
NC score	0.480386 (rank : 12)	θ value	0.00228821 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	26
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TEFF2_MOUSE
NC score	0.408091 (rank : 13)	θ value	1.87187e-05 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

NRG4_HUMAN
NC score	0.407444 (rank : 14)	θ value	0.0148317 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

TEFF2_HUMAN
NC score	0.407038 (rank : 15)	θ value	1.87187e-05 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	211	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

NRG4_MOUSE
NC score	0.358328 (rank : 16)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	79	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG2_MOUSE
NC score	0.217250 (rank : 17)	θ value	0.0431538 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

NRG2_HUMAN
NC score	0.214467 (rank : 18)	θ value	0.00665767 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG1_HUMAN
NC score	0.203458 (rank : 19)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	285	Shared Neighborhood Hits	28
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NRG3_MOUSE
NC score	0.172184 (rank : 20)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

NRG3_HUMAN
NC score	0.168159 (rank : 21)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	119	Shared Neighborhood Hits	25
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

SMDF_HUMAN
NC score	0.157046 (rank : 22)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	117	Shared Neighborhood Hits	25
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

EGF_HUMAN
NC score	0.152454 (rank : 23)	θ value	0.000158464 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	343	Shared Neighborhood Hits	32
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
NC score	0.140156 (rank : 24)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

LYAM1_HUMAN
NC score	0.088418 (rank : 25)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	315	Shared Neighborhood Hits	18
SwissProt Accessions	P14151, P15023	Gene names	SELL, LNHR, LYAM1
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (TQ1) (gp90-MEL) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

LYAM2_MOUSE
NC score	0.074081 (rank : 26)	θ value	0.0330416 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	420	Shared Neighborhood Hits	20
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LYAM1_MOUSE
NC score	0.069360 (rank : 27)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	332	Shared Neighborhood Hits	14
SwissProt Accessions	P18337	Gene names	Sell, Lnhr, Ly-22
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

DNER_HUMAN
NC score	0.060379 (rank : 28)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DNER_MOUSE
NC score	0.057439 (rank : 29)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	413	Shared Neighborhood Hits	29
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

LYAM2_HUMAN
NC score	0.056262 (rank : 30)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

SIM1_MOUSE
NC score	0.040441 (rank : 31)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SLIT3_MOUSE
NC score	0.040182 (rank : 32)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	700	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SAMD9_HUMAN
NC score	0.040051 (rank : 33)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

CUBN_MOUSE
NC score	0.038204 (rank : 34)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	477	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SIM1_HUMAN
NC score	0.035724 (rank : 35)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

TSP2_HUMAN
NC score	0.035704 (rank : 36)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	359	Shared Neighborhood Hits	12
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

FATH_HUMAN
NC score	0.028265 (rank : 37)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

HABP2_MOUSE
NC score	0.019728 (rank : 38)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

RPTN_MOUSE
NC score	0.018000 (rank : 39)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	650	Shared Neighborhood Hits	2
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

CJ012_HUMAN
NC score	0.014916 (rank : 40)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	467	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

TBL1X_HUMAN
NC score	0.011832 (rank : 41)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	329	Shared Neighborhood Hits	3
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

TBLX_MOUSE
NC score	0.011056 (rank : 42)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).