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Network neighborhood for query Sequence : TF2H1_HUMAN

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TF2H1_HUMAN
SwissProt Accessions	P32780, Q9H5K5, Q9NQD9	Gene names	GTF2H1, BTF2
Domain Architecture
Description	TFIIH basal transcription factor complex p62 subunit (Basic transcription factor 62 kDa subunit) (BTF2-p62) (General transcription factor IIH polypeptide 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TF2H1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P32780, Q9H5K5, Q9NQD9	Gene names	GTF2H1, BTF2
Domain Architecture
Description	TFIIH basal transcription factor complex p62 subunit (Basic transcription factor 62 kDa subunit) (BTF2-p62) (General transcription factor IIH polypeptide 1).

TF2H1_MOUSE
θ value	0 (rank : 2)	NC score	0.997211 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBA9, O35637	Gene names	Gtf2h1
Domain Architecture
Description	TFIIH basal transcription factor complex p62 subunit (Basic transcription factor 62 kDa subunit) (BTF2-p62) (General transcription factor IIH polypeptide 1).

CARD6_HUMAN
θ value	0.0330416 (rank : 3)	NC score	0.105075 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

TAC2N_MOUSE
θ value	1.38821 (rank : 4)	NC score	0.055662 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

SEP10_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.025835 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0V9, Q9HAH6	Gene names	SEPT10
Domain Architecture	No domain graphic available
Description	Septin-10.

MO4L2_HUMAN
θ value	2.36792 (rank : 6)	NC score	0.023750 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

SYNE2_HUMAN
θ value	2.36792 (rank : 7)	NC score	0.017884 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	1323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

HHEX_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.017953 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q03014	Gene names	HHEX, HEX, PRH, PRHX
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

HHEX_MOUSE
θ value	4.03905 (rank : 9)	NC score	0.018020 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P43120	Gene names	Hhex, Prhx
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

TPR_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.009346 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	1921	Shared Neighborhood Hits	7
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CENPE_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.006609 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	2060	Shared Neighborhood Hits	6
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

EVPL_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.012320 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

SEP10_MOUSE
θ value	6.88961 (rank : 13)	NC score	0.018428 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C650, Q7TSA5	Gene names	Sept10
Domain Architecture	No domain graphic available
Description	Septin-10.

CABL1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.012738 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

NEP_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.007565 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

RPA1_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.011047 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	O95602, Q9UEH0, Q9UFT9	Gene names	POLR1A
Domain Architecture
Description	DNA-directed RNA polymerase I largest subunit (EC 2.7.7.6) (RNA polymerase I 194 kDa subunit) (RPA194).

USBP1_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.025045 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R370	Gene names	Ushbp1
Domain Architecture	No domain graphic available
Description	USH1C-binding protein 1 (Usher syndrome type-1C protein-binding protein 1).

Hits sorted by NC score

TF2H1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P32780, Q9H5K5, Q9NQD9	Gene names	GTF2H1, BTF2
Domain Architecture
Description	TFIIH basal transcription factor complex p62 subunit (Basic transcription factor 62 kDa subunit) (BTF2-p62) (General transcription factor IIH polypeptide 1).

TF2H1_MOUSE
NC score	0.997211 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBA9, O35637	Gene names	Gtf2h1
Domain Architecture
Description	TFIIH basal transcription factor complex p62 subunit (Basic transcription factor 62 kDa subunit) (BTF2-p62) (General transcription factor IIH polypeptide 1).

CARD6_HUMAN
NC score	0.105075 (rank : 3)	θ value	0.0330416 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

TAC2N_MOUSE
NC score	0.055662 (rank : 4)	θ value	1.38821 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

SEP10_HUMAN
NC score	0.025835 (rank : 5)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0V9, Q9HAH6	Gene names	SEPT10
Domain Architecture	No domain graphic available
Description	Septin-10.

USBP1_MOUSE
NC score	0.025045 (rank : 6)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R370	Gene names	Ushbp1
Domain Architecture	No domain graphic available
Description	USH1C-binding protein 1 (Usher syndrome type-1C protein-binding protein 1).

MO4L2_HUMAN
NC score	0.023750 (rank : 7)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

SEP10_MOUSE
NC score	0.018428 (rank : 8)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C650, Q7TSA5	Gene names	Sept10
Domain Architecture	No domain graphic available
Description	Septin-10.

HHEX_MOUSE
NC score	0.018020 (rank : 9)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P43120	Gene names	Hhex, Prhx
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

HHEX_HUMAN
NC score	0.017953 (rank : 10)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q03014	Gene names	HHEX, HEX, PRH, PRHX
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

SYNE2_HUMAN
NC score	0.017884 (rank : 11)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	1323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CABL1_MOUSE
NC score	0.012738 (rank : 12)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

EVPL_HUMAN
NC score	0.012320 (rank : 13)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

RPA1_HUMAN
NC score	0.011047 (rank : 14)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	O95602, Q9UEH0, Q9UFT9	Gene names	POLR1A
Domain Architecture
Description	DNA-directed RNA polymerase I largest subunit (EC 2.7.7.6) (RNA polymerase I 194 kDa subunit) (RPA194).

TPR_HUMAN
NC score	0.009346 (rank : 15)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	1921	Shared Neighborhood Hits	7
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

NEP_HUMAN
NC score	0.007565 (rank : 16)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

CENPE_HUMAN
NC score	0.006609 (rank : 17)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	2060	Shared Neighborhood Hits	6
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).