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Network neighborhood for query Sequence : P5CS_HUMAN

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P5CS_HUMAN
SwissProt Accessions	P54886, O95952, Q9UM72	Gene names	ALDH18A1, P5CS, PYCS
Domain Architecture
Description	Delta 1-pyrroline-5-carboxylate synthetase (P5CS) (Aldehyde dehydrogenase 18 family member A1) [Includes: Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

P5CS_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P54886, O95952, Q9UM72	Gene names	ALDH18A1, P5CS, PYCS
Domain Architecture
Description	Delta 1-pyrroline-5-carboxylate synthetase (P5CS) (Aldehyde dehydrogenase 18 family member A1) [Includes: Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)].

P5CS_MOUSE
θ value	0 (rank : 2)	NC score	0.999302 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z110, Q9R1P6	Gene names	Aldh18a1, P5cs, Pycs
Domain Architecture
Description	Delta 1-pyrroline-5-carboxylate synthetase (P5CS) (Aldehyde dehydrogenase 18 family member A1) [Includes: Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)].

MASTL_MOUSE
θ value	1.38821 (rank : 3)	NC score	0.014217 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	862	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_HUMAN
θ value	1.81305 (rank : 4)	NC score	0.013481 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	894	Shared Neighborhood Hits	4
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

ZNFX1_HUMAN
θ value	3.0926 (rank : 5)	NC score	0.032590 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

AL3A1_MOUSE
θ value	6.88961 (rank : 6)	NC score	0.012021 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P47739, Q9R203	Gene names	Aldh3a1, Ahd-4, Ahd4, Aldh3, Aldh4
Domain Architecture
Description	Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDH class 3) (Dioxin-inducible aldehyde dehydrogenase 3).

AL3A2_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.012297 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	P51648, Q93011, Q96J37	Gene names	ALDH3A2, ALDH10, FALDH
Domain Architecture
Description	Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase, microsomal) (Aldehyde dehydrogenase family 3 member A2) (Aldehyde dehydrogenase 10).

BIRC6_HUMAN
θ value	8.99809 (rank : 8)	NC score	0.021351 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

DGKZ_HUMAN
θ value	8.99809 (rank : 9)	NC score	0.006461 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	551	Shared Neighborhood Hits	2
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

OPTN_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.005172 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	827	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

ZNFX1_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.024805 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	407	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

Hits sorted by NC score

P5CS_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P54886, O95952, Q9UM72	Gene names	ALDH18A1, P5CS, PYCS
Domain Architecture
Description	Delta 1-pyrroline-5-carboxylate synthetase (P5CS) (Aldehyde dehydrogenase 18 family member A1) [Includes: Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)].

P5CS_MOUSE
NC score	0.999302 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z110, Q9R1P6	Gene names	Aldh18a1, P5cs, Pycs
Domain Architecture
Description	Delta 1-pyrroline-5-carboxylate synthetase (P5CS) (Aldehyde dehydrogenase 18 family member A1) [Includes: Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)].

ZNFX1_HUMAN
NC score	0.032590 (rank : 3)	θ value	3.0926 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

ZNFX1_MOUSE
NC score	0.024805 (rank : 4)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	407	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

BIRC6_HUMAN
NC score	0.021351 (rank : 5)	θ value	8.99809 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

MASTL_MOUSE
NC score	0.014217 (rank : 6)	θ value	1.38821 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	862	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_HUMAN
NC score	0.013481 (rank : 7)	θ value	1.81305 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	894	Shared Neighborhood Hits	4
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

AL3A2_HUMAN
NC score	0.012297 (rank : 8)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	P51648, Q93011, Q96J37	Gene names	ALDH3A2, ALDH10, FALDH
Domain Architecture
Description	Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase, microsomal) (Aldehyde dehydrogenase family 3 member A2) (Aldehyde dehydrogenase 10).

AL3A1_MOUSE
NC score	0.012021 (rank : 9)	θ value	6.88961 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P47739, Q9R203	Gene names	Aldh3a1, Ahd-4, Ahd4, Aldh3, Aldh4
Domain Architecture
Description	Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDH class 3) (Dioxin-inducible aldehyde dehydrogenase 3).

DGKZ_HUMAN
NC score	0.006461 (rank : 10)	θ value	8.99809 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	551	Shared Neighborhood Hits	2
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

OPTN_HUMAN
NC score	0.005172 (rank : 11)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	827	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).