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Network neighborhood for query Sequence : METH_HUMAN

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METH_HUMAN
SwissProt Accessions	Q99707, Q99713, Q99723	Gene names	MTR
Domain Architecture
Description	Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

METH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q99707, Q99713, Q99723	Gene names	MTR
Domain Architecture
Description	Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS).

BHMT_HUMAN
θ value	1.17247e-07 (rank : 2)	NC score	0.346264 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q93088, Q9UNI9	Gene names	BHMT
Domain Architecture
Description	Betaine--homocysteine S-methyltransferase (EC 2.1.1.5).

BHMT_MOUSE
θ value	2.61198e-07 (rank : 3)	NC score	0.342888 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O35490	Gene names	Bhmt
Domain Architecture
Description	Betaine--homocysteine S-methyltransferase (EC 2.1.1.5).

DNJCD_HUMAN
θ value	0.62314 (rank : 4)	NC score	0.061528 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	O75165, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9	Gene names	DNAJC13, KIAA0678, RME8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8).

CAD23_MOUSE
θ value	1.38821 (rank : 5)	NC score	0.012053 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

CCD91_MOUSE
θ value	1.81305 (rank : 6)	NC score	0.022438 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	699	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

TIE2_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.005957 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	1192	Shared Neighborhood Hits	2
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

IDHC_MOUSE
θ value	3.0926 (rank : 8)	NC score	0.034864 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O88844	Gene names	Idh1
Domain Architecture
Description	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP).

NR2E3_MOUSE
θ value	4.03905 (rank : 9)	NC score	0.009601 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	113	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

HYAL2_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.018399 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	O35632, O35631, Q99MS9, Q99MT0	Gene names	Hyal2
Domain Architecture
Description	Hyaluronidase-2 precursor (EC 3.2.1.35) (Hyal-2) (Hyaluronoglucosaminidase-2) (LUCA-2).

ARRD2_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.012725 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

IDHC_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.027121 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O75874, Q93090, Q9NTJ9, Q9UKW8	Gene names	IDH1, PICD
Domain Architecture
Description	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP).

Hits sorted by NC score

METH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q99707, Q99713, Q99723	Gene names	MTR
Domain Architecture
Description	Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS).

BHMT_HUMAN
NC score	0.346264 (rank : 2)	θ value	1.17247e-07 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q93088, Q9UNI9	Gene names	BHMT
Domain Architecture
Description	Betaine--homocysteine S-methyltransferase (EC 2.1.1.5).

BHMT_MOUSE
NC score	0.342888 (rank : 3)	θ value	2.61198e-07 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O35490	Gene names	Bhmt
Domain Architecture
Description	Betaine--homocysteine S-methyltransferase (EC 2.1.1.5).

DNJCD_HUMAN
NC score	0.061528 (rank : 4)	θ value	0.62314 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	O75165, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9	Gene names	DNAJC13, KIAA0678, RME8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8).

IDHC_MOUSE
NC score	0.034864 (rank : 5)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O88844	Gene names	Idh1
Domain Architecture
Description	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP).

IDHC_HUMAN
NC score	0.027121 (rank : 6)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O75874, Q93090, Q9NTJ9, Q9UKW8	Gene names	IDH1, PICD
Domain Architecture
Description	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP).

CCD91_MOUSE
NC score	0.022438 (rank : 7)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	699	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

HYAL2_MOUSE
NC score	0.018399 (rank : 8)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	O35632, O35631, Q99MS9, Q99MT0	Gene names	Hyal2
Domain Architecture
Description	Hyaluronidase-2 precursor (EC 3.2.1.35) (Hyal-2) (Hyaluronoglucosaminidase-2) (LUCA-2).

ARRD2_HUMAN
NC score	0.012725 (rank : 9)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

CAD23_MOUSE
NC score	0.012053 (rank : 10)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

NR2E3_MOUSE
NC score	0.009601 (rank : 11)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	113	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

TIE2_HUMAN
NC score	0.005957 (rank : 12)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	1192	Shared Neighborhood Hits	2
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).