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Network neighborhood for query Sequence : MEN1_HUMAN

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MEN1_HUMAN
SwissProt Accessions	O00255, O00632, Q9BUK2	Gene names	MEN1, SCG2
Domain Architecture
Description	Menin.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MEN1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	O00255, O00632, Q9BUK2	Gene names	MEN1, SCG2
Domain Architecture
Description	Menin.

MEN1_MOUSE
θ value	0 (rank : 2)	NC score	0.990814 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

RGS3_HUMAN
θ value	0.0961366 (rank : 3)	NC score	0.045530 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	1375	Shared Neighborhood Hits	12
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CGRE1_HUMAN
θ value	0.163984 (rank : 4)	NC score	0.056656 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

KIF2A_MOUSE
θ value	0.279714 (rank : 5)	NC score	0.045663 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P28740	Gene names	Kif2a, Kif2, Kns2
Domain Architecture
Description	Kinesin-like protein KIF2A.

ZBP1_HUMAN
θ value	0.47712 (rank : 6)	NC score	0.062028 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

ZN688_HUMAN
θ value	0.47712 (rank : 7)	NC score	0.006502 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	873	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

JADE2_MOUSE
θ value	0.62314 (rank : 8)	NC score	0.037595 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	560	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

KIF2A_HUMAN
θ value	0.62314 (rank : 9)	NC score	0.042102 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	O00139, Q8N5Q7	Gene names	KIF2A, KIF2, KNS2
Domain Architecture
Description	Kinesin-like protein KIF2A (Kinesin-2) (HK2).

NHRF2_MOUSE
θ value	0.813845 (rank : 10)	NC score	0.026715 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

OGFR_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.033339 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	1582	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SON_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.019826 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

M3K11_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.005091 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	1136	Shared Neighborhood Hits	8
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RP3A_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.013987 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	510	Shared Neighborhood Hits	8
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

PCLO_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.018577 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	2275	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SPEG_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.005124 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1959	Shared Neighborhood Hits	12
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CABIN_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.025217 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	490	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

GAK_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.002950 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1028	Shared Neighborhood Hits	5
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

TLN1_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.016979 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.017041 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

ZN385_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.013527 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	614	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

Hits sorted by NC score

MEN1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	O00255, O00632, Q9BUK2	Gene names	MEN1, SCG2
Domain Architecture
Description	Menin.

MEN1_MOUSE
NC score	0.990814 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

ZBP1_HUMAN
NC score	0.062028 (rank : 3)	θ value	0.47712 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

CGRE1_HUMAN
NC score	0.056656 (rank : 4)	θ value	0.163984 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

KIF2A_MOUSE
NC score	0.045663 (rank : 5)	θ value	0.279714 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P28740	Gene names	Kif2a, Kif2, Kns2
Domain Architecture
Description	Kinesin-like protein KIF2A.

RGS3_HUMAN
NC score	0.045530 (rank : 6)	θ value	0.0961366 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	1375	Shared Neighborhood Hits	12
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

KIF2A_HUMAN
NC score	0.042102 (rank : 7)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	O00139, Q8N5Q7	Gene names	KIF2A, KIF2, KNS2
Domain Architecture
Description	Kinesin-like protein KIF2A (Kinesin-2) (HK2).

JADE2_MOUSE
NC score	0.037595 (rank : 8)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	560	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

OGFR_HUMAN
NC score	0.033339 (rank : 9)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	1582	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

NHRF2_MOUSE
NC score	0.026715 (rank : 10)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

CABIN_HUMAN
NC score	0.025217 (rank : 11)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	490	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

SON_HUMAN
NC score	0.019826 (rank : 12)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PCLO_MOUSE
NC score	0.018577 (rank : 13)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	2275	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TLN1_MOUSE
NC score	0.017041 (rank : 14)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN1_HUMAN
NC score	0.016979 (rank : 15)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

RP3A_MOUSE
NC score	0.013987 (rank : 16)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	510	Shared Neighborhood Hits	8
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

ZN385_HUMAN
NC score	0.013527 (rank : 17)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	614	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZN688_HUMAN
NC score	0.006502 (rank : 18)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	873	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

SPEG_MOUSE
NC score	0.005124 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	1959	Shared Neighborhood Hits	12
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

M3K11_HUMAN
NC score	0.005091 (rank : 20)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	1136	Shared Neighborhood Hits	8
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

GAK_HUMAN
NC score	0.002950 (rank : 21)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	1028	Shared Neighborhood Hits	5
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).