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Network neighborhood for query Sequence : LGMN_HUMAN

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LGMN_HUMAN
SwissProt Accessions	Q99538, O00123	Gene names	LGMN, PRSC1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LGMN_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q99538, O00123	Gene names	LGMN, PRSC1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

LGMN_MOUSE
θ value	0 (rank : 2)	NC score	0.995979 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	O89017	Gene names	Lgmn, Prsc1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

GPI8_MOUSE
θ value	1.16704e-23 (rank : 3)	NC score	0.696256 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXY9, Q8BH63	Gene names	Pigk
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K).

GPI8_HUMAN
θ value	1.5242e-23 (rank : 4)	NC score	0.695492 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q92643, O14822, Q5TG77	Gene names	PIGK, GPI8
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) (hGPI8).

IRS2_MOUSE
θ value	0.62314 (rank : 5)	NC score	0.042363 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

CP135_MOUSE
θ value	1.38821 (rank : 6)	NC score	0.012148 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	1278	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GRIA3_MOUSE
θ value	1.38821 (rank : 7)	NC score	0.019079 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2W9, Q5DTJ0	Gene names	Gria3, Glur3, Kiaa4184
Domain Architecture	No domain graphic available
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

SMC3_HUMAN
θ value	1.38821 (rank : 8)	NC score	0.023728 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	1186	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.023772 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	1187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

GRIA3_HUMAN
θ value	1.81305 (rank : 10)	NC score	0.018581 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P42263, Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2	Gene names	GRIA3, GLUR3, GLURC
Domain Architecture
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

HES6_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.033956 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

CI090_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.028260 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q69YI7, Q8WU12	Gene names	C9orf90
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf90.

PIAS3_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.018188 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6X2, Q9UFI3	Gene names	PIAS3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

SPON1_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.019295 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

CE290_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.009763 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	1553	Shared Neighborhood Hits	8
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

HES6_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.030606 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

MORC4_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.015726 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

MYO5B_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.007183 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

AB1IP_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.012287 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

DIAP2_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.009376 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

H6ST1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.022455 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O60243, Q53SL2, Q9BVI1	Gene names	HS6ST1, HS6ST
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 1 (EC 2.8.2.-) (HS6ST-1).

H6ST1_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.022444 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYK5	Gene names	Hs6st1
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 1 (EC 2.8.2.-) (HS6ST-1) (mHS6ST- 1).

PIAS3_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.015350 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	O54714, Q80WF8, Q8R598	Gene names	Pias3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

Hits sorted by NC score

LGMN_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q99538, O00123	Gene names	LGMN, PRSC1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

LGMN_MOUSE
NC score	0.995979 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	O89017	Gene names	Lgmn, Prsc1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

GPI8_MOUSE
NC score	0.696256 (rank : 3)	θ value	1.16704e-23 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXY9, Q8BH63	Gene names	Pigk
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K).

GPI8_HUMAN
NC score	0.695492 (rank : 4)	θ value	1.5242e-23 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q92643, O14822, Q5TG77	Gene names	PIGK, GPI8
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) (hGPI8).

IRS2_MOUSE
NC score	0.042363 (rank : 5)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

HES6_HUMAN
NC score	0.033956 (rank : 6)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.030606 (rank : 7)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

CI090_HUMAN
NC score	0.028260 (rank : 8)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q69YI7, Q8WU12	Gene names	C9orf90
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf90.

SMC3_MOUSE
NC score	0.023772 (rank : 9)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	1187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.023728 (rank : 10)	θ value	1.38821 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	1186	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

H6ST1_HUMAN
NC score	0.022455 (rank : 11)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O60243, Q53SL2, Q9BVI1	Gene names	HS6ST1, HS6ST
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 1 (EC 2.8.2.-) (HS6ST-1).

H6ST1_MOUSE
NC score	0.022444 (rank : 12)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYK5	Gene names	Hs6st1
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 1 (EC 2.8.2.-) (HS6ST-1) (mHS6ST- 1).

SPON1_HUMAN
NC score	0.019295 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

GRIA3_MOUSE
NC score	0.019079 (rank : 14)	θ value	1.38821 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2W9, Q5DTJ0	Gene names	Gria3, Glur3, Kiaa4184
Domain Architecture	No domain graphic available
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

GRIA3_HUMAN
NC score	0.018581 (rank : 15)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P42263, Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2	Gene names	GRIA3, GLUR3, GLURC
Domain Architecture
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

PIAS3_HUMAN
NC score	0.018188 (rank : 16)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6X2, Q9UFI3	Gene names	PIAS3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

MORC4_HUMAN
NC score	0.015726 (rank : 17)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

PIAS3_MOUSE
NC score	0.015350 (rank : 18)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	O54714, Q80WF8, Q8R598	Gene names	Pias3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

AB1IP_HUMAN
NC score	0.012287 (rank : 19)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

CP135_MOUSE
NC score	0.012148 (rank : 20)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	1278	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CE290_HUMAN
NC score	0.009763 (rank : 21)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	1553	Shared Neighborhood Hits	8
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

DIAP2_HUMAN
NC score	0.009376 (rank : 22)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

MYO5B_HUMAN
NC score	0.007183 (rank : 23)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).