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Network neighborhood for query Sequence : HEM6_HUMAN

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HEM6_HUMAN
SwissProt Accessions	P36551, Q14060, Q8IZ45, Q96AF3	Gene names	CPOX, CPO, CPX
Domain Architecture
Description	Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) (COX).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HEM6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P36551, Q14060, Q8IZ45, Q96AF3	Gene names	CPOX, CPO, CPX
Domain Architecture
Description	Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) (COX).

HEM6_MOUSE
θ value	0 (rank : 2)	NC score	0.995537 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P36552, Q7TQ36, Q8VD08	Gene names	Cpox, Cpo
Domain Architecture
Description	Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) (COX).

COHA1_HUMAN
θ value	3.0926 (rank : 3)	NC score	0.014607 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

LBXCO_HUMAN
θ value	4.03905 (rank : 4)	NC score	0.028579 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

TAL1_HUMAN
θ value	4.03905 (rank : 5)	NC score	0.017599 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

MBD2_HUMAN
θ value	5.27518 (rank : 6)	NC score	0.016984 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBB5, O95242, Q9UIS8	Gene names	MBD2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Demethylase) (DMTase).

NOTC4_HUMAN
θ value	5.27518 (rank : 7)	NC score	0.004053 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	905	Shared Neighborhood Hits	2
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

CO5A1_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.007219 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	434	Shared Neighborhood Hits	3
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

K2C1_HUMAN
θ value	6.88961 (rank : 9)	NC score	0.003376 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	624	Shared Neighborhood Hits	2
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

EFNB3_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.017589 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q15768, O00680, Q8TBH7, Q92875	Gene names	EFNB3, EPLG8, LERK8
Domain Architecture
Description	Ephrin-B3 precursor (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) (EPH-related receptor transmembrane ligand ELK-L3).

EFNB3_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.017268 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O35393	Gene names	Efnb3
Domain Architecture
Description	Ephrin-B3 precursor.

ELOA2_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.012866 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

LBXCO_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.024970 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

Hits sorted by NC score

HEM6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P36551, Q14060, Q8IZ45, Q96AF3	Gene names	CPOX, CPO, CPX
Domain Architecture
Description	Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) (COX).

HEM6_MOUSE
NC score	0.995537 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P36552, Q7TQ36, Q8VD08	Gene names	Cpox, Cpo
Domain Architecture
Description	Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) (COX).

LBXCO_HUMAN
NC score	0.028579 (rank : 3)	θ value	4.03905 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

LBXCO_MOUSE
NC score	0.024970 (rank : 4)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

TAL1_HUMAN
NC score	0.017599 (rank : 5)	θ value	4.03905 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

EFNB3_HUMAN
NC score	0.017589 (rank : 6)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q15768, O00680, Q8TBH7, Q92875	Gene names	EFNB3, EPLG8, LERK8
Domain Architecture
Description	Ephrin-B3 precursor (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) (EPH-related receptor transmembrane ligand ELK-L3).

EFNB3_MOUSE
NC score	0.017268 (rank : 7)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O35393	Gene names	Efnb3
Domain Architecture
Description	Ephrin-B3 precursor.

MBD2_HUMAN
NC score	0.016984 (rank : 8)	θ value	5.27518 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBB5, O95242, Q9UIS8	Gene names	MBD2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Demethylase) (DMTase).

COHA1_HUMAN
NC score	0.014607 (rank : 9)	θ value	3.0926 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

ELOA2_HUMAN
NC score	0.012866 (rank : 10)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

CO5A1_HUMAN
NC score	0.007219 (rank : 11)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	434	Shared Neighborhood Hits	3
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

NOTC4_HUMAN
NC score	0.004053 (rank : 12)	θ value	5.27518 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	905	Shared Neighborhood Hits	2
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

K2C1_HUMAN
NC score	0.003376 (rank : 13)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	624	Shared Neighborhood Hits	2
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).