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Network neighborhood for query Sequence : CO5_HUMAN

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CO5_HUMAN
SwissProt Accessions	P01031	Gene names	C5
Domain Architecture
Description	Complement C5 precursor [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CO3_HUMAN
θ value	0 (rank : 1)	NC score	0.954731 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

CO3_MOUSE
θ value	0 (rank : 2)	NC score	0.954435 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	P01027, Q61370	Gene names	C3
Domain Architecture
Description	Complement C3 precursor (HSE-MSF) [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3, isoform Short; Complement C3f fragment].

CO5_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	P01031	Gene names	C5
Domain Architecture
Description	Complement C5 precursor [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

CO5_MOUSE
θ value	0 (rank : 4)	NC score	0.997130 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

CO4B_MOUSE
θ value	6.19918e-134 (rank : 5)	NC score	0.923614 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P01029, Q31201, Q61372, Q61859, Q62353	Gene names	C4b, C4
Domain Architecture
Description	Complement C4-B precursor [Contains: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain].

CO4B_HUMAN
θ value	1.21547e-113 (rank : 6)	NC score	0.917772 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P0C0L5, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q9NPK5, Q9UIP5	Gene names	C4B
Domain Architecture	No domain graphic available
Description	Complement C4-B precursor (Basic complement C4) [Contains: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain].

CO4A_HUMAN
θ value	2.07327e-113 (rank : 7)	NC score	0.917608 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P0C0L4, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q5JQM8, Q9NPK5, Q9UIP5	Gene names	C4A
Domain Architecture	No domain graphic available
Description	Complement C4-A precursor (Acidic complement C4) [Contains: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain].

A2MG_HUMAN
θ value	4.83544e-70 (rank : 8)	NC score	0.831344 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	P01023, Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97	Gene names	A2M
Domain Architecture
Description	Alpha-2-macroglobulin precursor (Alpha-2-M).

MUG1_MOUSE
θ value	2.24614e-67 (rank : 9)	NC score	0.816871 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	40	Shared Neighborhood Hits	12
SwissProt Accessions	P28665	Gene names	Mug1, Mug-1
Domain Architecture
Description	Murinoglobulin-1 precursor (MuG1).

MUG2_MOUSE
θ value	2.85459e-46 (rank : 10)	NC score	0.793166 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	P28666	Gene names	Mug2, Mug-2
Domain Architecture
Description	Murinoglobulin-2 precursor (MuG2).

PZP_HUMAN
θ value	2.41655e-45 (rank : 11)	NC score	0.812638 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P20742, Q15273	Gene names	PZP
Domain Architecture
Description	Pregnancy zone protein precursor.

A2MG_MOUSE
θ value	3.61106e-41 (rank : 12)	NC score	0.799315 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	Q61838, Q60628	Gene names	A2m
Domain Architecture
Description	Alpha-2-macroglobulin precursor (Alpha-2-M) [Contains: Alpha-2- macroglobulin 165 kDa subunit; Alpha-2-macroglobulin 35 kDa subunit].

ITAX_HUMAN
θ value	0.0961366 (rank : 13)	NC score	0.013888 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

DHX57_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.012142 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

IL6RB_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.019642 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

CTR3_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.009110 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

DLDH_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.016750 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

KREM1_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.008343 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

SSDH_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.006378 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	P51649	Gene names	ALDH5A1, SSADH
Domain Architecture
Description	Succinate semialdehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase).

PCTK2_HUMAN
θ value	5.27518 (rank : 20)	NC score	-0.001471 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	837	Shared Neighborhood Hits	2
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MGR1_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.006962 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

MGR1_MOUSE
θ value	6.88961 (rank : 22)	NC score	0.006952 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

TMC1_HUMAN
θ value	6.88961 (rank : 23)	NC score	0.006591 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

K0586_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.007402 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	311	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MGR5_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.006381 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

Hits sorted by NC score

CO5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	P01031	Gene names	C5
Domain Architecture
Description	Complement C5 precursor [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

CO5_MOUSE
NC score	0.997130 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

CO3_HUMAN
NC score	0.954731 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

CO3_MOUSE
NC score	0.954435 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	P01027, Q61370	Gene names	C3
Domain Architecture
Description	Complement C3 precursor (HSE-MSF) [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3, isoform Short; Complement C3f fragment].

CO4B_MOUSE
NC score	0.923614 (rank : 5)	θ value	6.19918e-134 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P01029, Q31201, Q61372, Q61859, Q62353	Gene names	C4b, C4
Domain Architecture
Description	Complement C4-B precursor [Contains: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain].

CO4B_HUMAN
NC score	0.917772 (rank : 6)	θ value	1.21547e-113 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P0C0L5, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q9NPK5, Q9UIP5	Gene names	C4B
Domain Architecture	No domain graphic available
Description	Complement C4-B precursor (Basic complement C4) [Contains: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain].

CO4A_HUMAN
NC score	0.917608 (rank : 7)	θ value	2.07327e-113 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P0C0L4, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q5JQM8, Q9NPK5, Q9UIP5	Gene names	C4A
Domain Architecture	No domain graphic available
Description	Complement C4-A precursor (Acidic complement C4) [Contains: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain].

A2MG_HUMAN
NC score	0.831344 (rank : 8)	θ value	4.83544e-70 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	P01023, Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97	Gene names	A2M
Domain Architecture
Description	Alpha-2-macroglobulin precursor (Alpha-2-M).

MUG1_MOUSE
NC score	0.816871 (rank : 9)	θ value	2.24614e-67 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	40	Shared Neighborhood Hits	12
SwissProt Accessions	P28665	Gene names	Mug1, Mug-1
Domain Architecture
Description	Murinoglobulin-1 precursor (MuG1).

PZP_HUMAN
NC score	0.812638 (rank : 10)	θ value	2.41655e-45 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	P20742, Q15273	Gene names	PZP
Domain Architecture
Description	Pregnancy zone protein precursor.

A2MG_MOUSE
NC score	0.799315 (rank : 11)	θ value	3.61106e-41 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	Q61838, Q60628	Gene names	A2m
Domain Architecture
Description	Alpha-2-macroglobulin precursor (Alpha-2-M) [Contains: Alpha-2- macroglobulin 165 kDa subunit; Alpha-2-macroglobulin 35 kDa subunit].

MUG2_MOUSE
NC score	0.793166 (rank : 12)	θ value	2.85459e-46 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	P28666	Gene names	Mug2, Mug-2
Domain Architecture
Description	Murinoglobulin-2 precursor (MuG2).

IL6RB_HUMAN
NC score	0.019642 (rank : 13)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

DLDH_HUMAN
NC score	0.016750 (rank : 14)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

ITAX_HUMAN
NC score	0.013888 (rank : 15)	θ value	0.0961366 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

DHX57_MOUSE
NC score	0.012142 (rank : 16)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

CTR3_MOUSE
NC score	0.009110 (rank : 17)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

KREM1_MOUSE
NC score	0.008343 (rank : 18)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

K0586_HUMAN
NC score	0.007402 (rank : 19)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	311	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MGR1_HUMAN
NC score	0.006962 (rank : 20)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

MGR1_MOUSE
NC score	0.006952 (rank : 21)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

TMC1_HUMAN
NC score	0.006591 (rank : 22)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

MGR5_HUMAN
NC score	0.006381 (rank : 23)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

SSDH_HUMAN
NC score	0.006378 (rank : 24)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	P51649	Gene names	ALDH5A1, SSADH
Domain Architecture
Description	Succinate semialdehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase).

PCTK2_HUMAN
NC score	-0.001471 (rank : 25)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	837	Shared Neighborhood Hits	2
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).