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Network neighborhood for query Sequence : TRXR2_HUMAN

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TRXR2_HUMAN
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRXR2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

TRXR2_MOUSE
θ value	0 (rank : 2)	NC score	0.998186 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

TRXR1_MOUSE
θ value	3.73483e-155 (rank : 3)	NC score	0.987040 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

TRXR1_HUMAN
θ value	5.96274e-153 (rank : 4)	NC score	0.986632 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

GSHR_HUMAN
θ value	3.82246e-75 (rank : 5)	NC score	0.939858 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	P00390, Q7Z5C9, Q9NP63	Gene names	GSR, GLUR, GRD1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

GSHR_MOUSE
θ value	8.51556e-75 (rank : 6)	NC score	0.939599 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

DLDH_HUMAN
θ value	9.18288e-45 (rank : 7)	NC score	0.868126 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

DLDH_MOUSE
θ value	3.48949e-44 (rank : 8)	NC score	0.866169 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

ADPN_HUMAN
θ value	0.125558 (rank : 9)	NC score	0.085834 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

GPDM_MOUSE
θ value	0.163984 (rank : 10)	NC score	0.093653 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	101	Shared Neighborhood Hits	7
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

GPDM_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.097365 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

SQRD_HUMAN
θ value	0.62314 (rank : 12)	NC score	0.050044 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6N5, Q9UQM8	Gene names	SQRDL
Domain Architecture
Description	Sulfide:quinone oxidoreductase, mitochondrial precursor (EC 1.-.-.-).

IMA2_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.012717 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

MICA2_MOUSE
θ value	2.36792 (rank : 14)	NC score	0.022994 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

MICA2_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.019964 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	174	Shared Neighborhood Hits	7
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

CJ033_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.068786 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

CJ033_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.061034 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

CHSS1_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.005918 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZQ11	Gene names	Chsy1, Kiaa0990
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate synthase 1 (EC 2.4.1.175) (Glucuronosyl-N- acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase) (Chondroitin sulfate synthase 1) (N- acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) (EC 2.4.1.226) (Chondroitin glucuronyltransferase II) (N- acetylgalactosaminyltransferase II).

Hits sorted by NC score

TRXR2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

TRXR2_MOUSE
NC score	0.998186 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

TRXR1_MOUSE
NC score	0.987040 (rank : 3)	θ value	3.73483e-155 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

TRXR1_HUMAN
NC score	0.986632 (rank : 4)	θ value	5.96274e-153 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

GSHR_HUMAN
NC score	0.939858 (rank : 5)	θ value	3.82246e-75 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	P00390, Q7Z5C9, Q9NP63	Gene names	GSR, GLUR, GRD1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

GSHR_MOUSE
NC score	0.939599 (rank : 6)	θ value	8.51556e-75 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

DLDH_HUMAN
NC score	0.868126 (rank : 7)	θ value	9.18288e-45 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

DLDH_MOUSE
NC score	0.866169 (rank : 8)	θ value	3.48949e-44 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

GPDM_HUMAN
NC score	0.097365 (rank : 9)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

GPDM_MOUSE
NC score	0.093653 (rank : 10)	θ value	0.163984 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	101	Shared Neighborhood Hits	7
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

ADPN_HUMAN
NC score	0.085834 (rank : 11)	θ value	0.125558 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

CJ033_HUMAN
NC score	0.068786 (rank : 12)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

CJ033_MOUSE
NC score	0.061034 (rank : 13)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

SQRD_HUMAN
NC score	0.050044 (rank : 14)	θ value	0.62314 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6N5, Q9UQM8	Gene names	SQRDL
Domain Architecture
Description	Sulfide:quinone oxidoreductase, mitochondrial precursor (EC 1.-.-.-).

MICA2_MOUSE
NC score	0.022994 (rank : 15)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

MICA2_HUMAN
NC score	0.019964 (rank : 16)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	174	Shared Neighborhood Hits	7
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

IMA2_HUMAN
NC score	0.012717 (rank : 17)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

CHSS1_MOUSE
NC score	0.005918 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZQ11	Gene names	Chsy1, Kiaa0990
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate synthase 1 (EC 2.4.1.175) (Glucuronosyl-N- acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase) (Chondroitin sulfate synthase 1) (N- acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) (EC 2.4.1.226) (Chondroitin glucuronyltransferase II) (N- acetylgalactosaminyltransferase II).