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Network neighborhood for query Sequence : PPAC3_HUMAN

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PPAC3_HUMAN
SwissProt Accessions	Q8NBV4, Q5T6P0, Q96SS7, Q9BRC3	Gene names	PPAPDC3, C9orf67
Domain Architecture	No domain graphic available
Description	Probable lipid phosphate phosphatase PPAPDC3 (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PPAC3_MOUSE
θ value	4.45295e-124 (rank : 1)	NC score	0.996191 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	Q91WB2	Gene names	Ppapdc3
Domain Architecture	No domain graphic available
Description	Probable lipid phosphate phosphatase PPAPDC3 (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 3).

PPAC3_HUMAN
θ value	1.69605e-115 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NBV4, Q5T6P0, Q96SS7, Q9BRC3	Gene names	PPAPDC3, C9orf67
Domain Architecture	No domain graphic available
Description	Probable lipid phosphate phosphatase PPAPDC3 (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 3).

PPAC2_MOUSE
θ value	8.85319e-56 (rank : 3)	NC score	0.955266 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D4F2	Gene names	Ppapdc2
Domain Architecture	No domain graphic available
Description	Presqualene diphosphate phosphatase (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 2).

PPAC2_HUMAN
θ value	9.78833e-55 (rank : 4)	NC score	0.954903 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY26, Q5JVJ6, Q8NCK9	Gene names	PPAPDC2
Domain Architecture	No domain graphic available
Description	Presqualene diphosphate phosphatase (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 2).

LPP3_HUMAN
θ value	0.0563607 (rank : 5)	NC score	0.134572 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	O14495, Q96GW0, Q99782	Gene names	PPAP2B, LPP3
Domain Architecture
Description	Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2b) (Phosphatidate phosphohydrolase type 2b) (PAP2b) (PAP- 2b) (PAP2-beta) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP).

SGPP1_HUMAN
θ value	0.0961366 (rank : 6)	NC score	0.182931 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX95, Q9H189	Gene names	SGPP1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (Spp1) (hSPPase1).

SGPP1_MOUSE
θ value	0.125558 (rank : 7)	NC score	0.186396 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI99	Gene names	Sgpp1, Spp1, Spph1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (SPP) (mSPP1).

LPP1_HUMAN
θ value	0.62314 (rank : 8)	NC score	0.084408 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	O14494, O60457, O60463	Gene names	PPAP2A, LPP1
Domain Architecture
Description	Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (Phosphatidate phosphohydrolase type 2a) (PAP2a) (PAP- 2a) (PAP2-alpha).

LPP3_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.107922 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q99JY8, Q3TVM4, Q3TXR7, Q8BTB7	Gene names	Ppap2b, Lpp3
Domain Architecture
Description	Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2b) (Phosphatidate phosphohydrolase type 2b) (PAP2b) (PAP- 2b) (PAP2-beta).

SGPP2_HUMAN
θ value	1.81305 (rank : 10)	NC score	0.080277 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IWX5, Q8N8Q6	Gene names	SGPP2
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 2 (EC 3.1.3.-) (Sphingosine-1- phosphatase 2) (SPPase2) (Spp2) (hSPP2).

LPP1_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.075466 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q61469, Q61690, Q8BPB8	Gene names	Ppap2a, Hpic53, Lpp1
Domain Architecture
Description	Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (Phosphatidate phosphohydrolase type 2a) (PAP2a) (PAP- 2a) (PAP2-alpha) (Hydrogen peroxide-inducible protein 53) (Hic53) (35 kDa PAP) (mPAP).

CAR10_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.011516 (rank : 16)
Query Neighborhood Hits	14	Target Neighborhood Hits	407	Shared Neighborhood Hits	2
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

PANK1_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.013563 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE04, Q7RTX6, Q7Z495, Q8TBQ8	Gene names	PANK1, PANK
Domain Architecture
Description	Pantothenate kinase 1 (EC 2.7.1.33) (Pantothenic acid kinase 1) (hPanK1) (hPanK).

SGPP2_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.075468 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q810K3	Gene names	Sgpp2
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 2 (EC 3.1.3.-) (Sphingosine-1- phosphatase 2) (SPPase2) (Spp2).

LPP2_HUMAN
θ value	θ > 10 (rank : 15)	NC score	0.053584 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	O43688	Gene names	PPAP2C, LPP2
Domain Architecture
Description	Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2c) (Phosphatidate phosphohydrolase type 2c) (PAP2c) (PAP- 2c) (PAP2-gamma) (PAP2-G).

LPP2_MOUSE
θ value	θ > 10 (rank : 16)	NC score	0.054263 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAX2, Q9WUA4	Gene names	Ppap2c, Lpp2
Domain Architecture
Description	Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2c) (Phosphatidate phosphohydrolase type 2c) (PAP2c) (PAP- 2c) (PAP2-gamma) (PAP2-G).

Hits sorted by NC score

PPAC3_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.69605e-115 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NBV4, Q5T6P0, Q96SS7, Q9BRC3	Gene names	PPAPDC3, C9orf67
Domain Architecture	No domain graphic available
Description	Probable lipid phosphate phosphatase PPAPDC3 (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 3).

PPAC3_MOUSE
NC score	0.996191 (rank : 2)	θ value	4.45295e-124 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	Q91WB2	Gene names	Ppapdc3
Domain Architecture	No domain graphic available
Description	Probable lipid phosphate phosphatase PPAPDC3 (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 3).

PPAC2_MOUSE
NC score	0.955266 (rank : 3)	θ value	8.85319e-56 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D4F2	Gene names	Ppapdc2
Domain Architecture	No domain graphic available
Description	Presqualene diphosphate phosphatase (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 2).

PPAC2_HUMAN
NC score	0.954903 (rank : 4)	θ value	9.78833e-55 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY26, Q5JVJ6, Q8NCK9	Gene names	PPAPDC2
Domain Architecture	No domain graphic available
Description	Presqualene diphosphate phosphatase (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 2).

SGPP1_MOUSE
NC score	0.186396 (rank : 5)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI99	Gene names	Sgpp1, Spp1, Spph1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (SPP) (mSPP1).

SGPP1_HUMAN
NC score	0.182931 (rank : 6)	θ value	0.0961366 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX95, Q9H189	Gene names	SGPP1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (Spp1) (hSPPase1).

LPP3_HUMAN
NC score	0.134572 (rank : 7)	θ value	0.0563607 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	O14495, Q96GW0, Q99782	Gene names	PPAP2B, LPP3
Domain Architecture
Description	Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2b) (Phosphatidate phosphohydrolase type 2b) (PAP2b) (PAP- 2b) (PAP2-beta) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP).

LPP3_MOUSE
NC score	0.107922 (rank : 8)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q99JY8, Q3TVM4, Q3TXR7, Q8BTB7	Gene names	Ppap2b, Lpp3
Domain Architecture
Description	Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2b) (Phosphatidate phosphohydrolase type 2b) (PAP2b) (PAP- 2b) (PAP2-beta).

LPP1_HUMAN
NC score	0.084408 (rank : 9)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	O14494, O60457, O60463	Gene names	PPAP2A, LPP1
Domain Architecture
Description	Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (Phosphatidate phosphohydrolase type 2a) (PAP2a) (PAP- 2a) (PAP2-alpha).

SGPP2_HUMAN
NC score	0.080277 (rank : 10)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IWX5, Q8N8Q6	Gene names	SGPP2
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 2 (EC 3.1.3.-) (Sphingosine-1- phosphatase 2) (SPPase2) (Spp2) (hSPP2).

SGPP2_MOUSE
NC score	0.075468 (rank : 11)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q810K3	Gene names	Sgpp2
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 2 (EC 3.1.3.-) (Sphingosine-1- phosphatase 2) (SPPase2) (Spp2).

LPP1_MOUSE
NC score	0.075466 (rank : 12)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q61469, Q61690, Q8BPB8	Gene names	Ppap2a, Hpic53, Lpp1
Domain Architecture
Description	Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (Phosphatidate phosphohydrolase type 2a) (PAP2a) (PAP- 2a) (PAP2-alpha) (Hydrogen peroxide-inducible protein 53) (Hic53) (35 kDa PAP) (mPAP).

LPP2_MOUSE
NC score	0.054263 (rank : 13)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAX2, Q9WUA4	Gene names	Ppap2c, Lpp2
Domain Architecture
Description	Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2c) (Phosphatidate phosphohydrolase type 2c) (PAP2c) (PAP- 2c) (PAP2-gamma) (PAP2-G).

LPP2_HUMAN
NC score	0.053584 (rank : 14)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	O43688	Gene names	PPAP2C, LPP2
Domain Architecture
Description	Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2c) (Phosphatidate phosphohydrolase type 2c) (PAP2c) (PAP- 2c) (PAP2-gamma) (PAP2-G).

PANK1_HUMAN
NC score	0.013563 (rank : 15)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE04, Q7RTX6, Q7Z495, Q8TBQ8	Gene names	PANK1, PANK
Domain Architecture
Description	Pantothenate kinase 1 (EC 2.7.1.33) (Pantothenic acid kinase 1) (hPanK1) (hPanK).

CAR10_MOUSE
NC score	0.011516 (rank : 16)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	407	Shared Neighborhood Hits	2
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).