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Network neighborhood for query Sequence : MBTP2_HUMAN

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MBTP2_HUMAN
SwissProt Accessions	O43462, Q9UM70, Q9UMD3	Gene names	MBTPS2, S2P
Domain Architecture
Description	Membrane-bound transcription factor site 2 protease (EC 3.4.24.85) (S2P endopeptidase) (Site-2 protease) (Sterol-regulatory element- binding proteins intramembrane protease).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MBTP2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	5	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	O43462, Q9UM70, Q9UMD3	Gene names	MBTPS2, S2P
Domain Architecture
Description	Membrane-bound transcription factor site 2 protease (EC 3.4.24.85) (S2P endopeptidase) (Site-2 protease) (Sterol-regulatory element- binding proteins intramembrane protease).

DLG5_HUMAN
θ value	0.125558 (rank : 2)	NC score	0.037803 (rank : 2)
Query Neighborhood Hits	5	Target Neighborhood Hits	1088	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

LRP1B_MOUSE
θ value	5.27518 (rank : 3)	NC score	0.009089 (rank : 5)
Query Neighborhood Hits	5	Target Neighborhood Hits	606	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

M4A10_HUMAN
θ value	5.27518 (rank : 4)	NC score	0.036282 (rank : 3)
Query Neighborhood Hits	5	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PG2, Q96PG3	Gene names	MS4A10
Domain Architecture
Description	Membrane-spanning 4-domains subfamily A member 10.

AT8B1_HUMAN
θ value	6.88961 (rank : 5)	NC score	0.010415 (rank : 4)
Query Neighborhood Hits	5	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O43520, Q9BTP8	Gene names	ATP8B1, ATPIC, FIC1, PFIC
Domain Architecture
Description	Probable phospholipid-transporting ATPase IC (EC 3.6.3.1) (Familial intrahepatic cholestasis type 1) (ATPase class I type 8B member 1).

Hits sorted by NC score

MBTP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	5	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	O43462, Q9UM70, Q9UMD3	Gene names	MBTPS2, S2P
Domain Architecture
Description	Membrane-bound transcription factor site 2 protease (EC 3.4.24.85) (S2P endopeptidase) (Site-2 protease) (Sterol-regulatory element- binding proteins intramembrane protease).

DLG5_HUMAN
NC score	0.037803 (rank : 2)	θ value	0.125558 (rank : 2)
Query Neighborhood Hits	5	Target Neighborhood Hits	1088	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

M4A10_HUMAN
NC score	0.036282 (rank : 3)	θ value	5.27518 (rank : 4)
Query Neighborhood Hits	5	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PG2, Q96PG3	Gene names	MS4A10
Domain Architecture
Description	Membrane-spanning 4-domains subfamily A member 10.

AT8B1_HUMAN
NC score	0.010415 (rank : 4)	θ value	6.88961 (rank : 5)
Query Neighborhood Hits	5	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O43520, Q9BTP8	Gene names	ATP8B1, ATPIC, FIC1, PFIC
Domain Architecture
Description	Probable phospholipid-transporting ATPase IC (EC 3.6.3.1) (Familial intrahepatic cholestasis type 1) (ATPase class I type 8B member 1).

LRP1B_MOUSE
NC score	0.009089 (rank : 5)	θ value	5.27518 (rank : 3)
Query Neighborhood Hits	5	Target Neighborhood Hits	606	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).