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Network neighborhood for query Sequence : GSH0_HUMAN

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GSH0_HUMAN
SwissProt Accessions	P48507, Q6FHC1, Q9NPX9, Q9NU74	Gene names	GCLM, GLCLR
Domain Architecture
Description	Glutamate--cysteine ligase regulatory subunit (EC 6.3.2.2) (Gamma- glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GSH0_HUMAN
θ value	1.68038e-147 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P48507, Q6FHC1, Q9NPX9, Q9NU74	Gene names	GCLM, GLCLR
Domain Architecture
Description	Glutamate--cysteine ligase regulatory subunit (EC 6.3.2.2) (Gamma- glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit).

GSH0_MOUSE
θ value	1.47209e-143 (rank : 2)	NC score	0.998813 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	O09172	Gene names	Gclm, Glclr
Domain Architecture
Description	Glutamate--cysteine ligase regulatory subunit (EC 6.3.2.2) (Gamma- glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit).

SYNE1_HUMAN
θ value	0.813845 (rank : 3)	NC score	0.020689 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	1484	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

AK1A1_HUMAN
θ value	3.0926 (rank : 4)	NC score	0.057740 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P14550	Gene names	AKR1A1, ALDR1, ALR
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1A1_MOUSE
θ value	3.0926 (rank : 5)	NC score	0.054947 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JII6, Q9CQI5, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3	Gene names	Akr1a1, Akr1a4
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1D1_MOUSE
θ value	3.0926 (rank : 6)	NC score	0.047291 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VCX1	Gene names	Akr1d1
Domain Architecture	No domain graphic available
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.99.6) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

AK1E1_MOUSE
θ value	4.03905 (rank : 7)	NC score	0.046676 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DCT1, O09125	Gene names	Akr1e1
Domain Architecture
Description	Aldo-keto reductase family 1 member E1 (EC 1.1.1.-).

AK1BA_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.044966 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O60218, O75890	Gene names	AKR1B10
Domain Architecture
Description	Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (Aldose reductase-like) (ARL-1) (Small intestine reductase) (SI reductase) (Aldose reductase-related protein) (ARP) (hARP).

ALDR_HUMAN
θ value	6.88961 (rank : 9)	NC score	0.040195 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	P15121, Q9BS21, Q9UCI9	Gene names	AKR1B1, ALDR1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

IGBP1_MOUSE
θ value	6.88961 (rank : 10)	NC score	0.029580 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

K0406_MOUSE
θ value	6.88961 (rank : 11)	NC score	0.030084 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

AK1D1_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.042591 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P51857	Gene names	AKR1D1, SRD5B1
Domain Architecture
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

CLIC2_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.018972 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O15247, O15174, Q5JT80, Q8TCE3	Gene names	CLIC2
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel protein 2 (XAP121).

RN5A_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.011157 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	608	Shared Neighborhood Hits	3
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

Hits sorted by NC score

GSH0_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.68038e-147 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P48507, Q6FHC1, Q9NPX9, Q9NU74	Gene names	GCLM, GLCLR
Domain Architecture
Description	Glutamate--cysteine ligase regulatory subunit (EC 6.3.2.2) (Gamma- glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit).

GSH0_MOUSE
NC score	0.998813 (rank : 2)	θ value	1.47209e-143 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	O09172	Gene names	Gclm, Glclr
Domain Architecture
Description	Glutamate--cysteine ligase regulatory subunit (EC 6.3.2.2) (Gamma- glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit).

AK1A1_HUMAN
NC score	0.057740 (rank : 3)	θ value	3.0926 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P14550	Gene names	AKR1A1, ALDR1, ALR
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1A1_MOUSE
NC score	0.054947 (rank : 4)	θ value	3.0926 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JII6, Q9CQI5, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3	Gene names	Akr1a1, Akr1a4
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1D1_MOUSE
NC score	0.047291 (rank : 5)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VCX1	Gene names	Akr1d1
Domain Architecture	No domain graphic available
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.99.6) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

AK1E1_MOUSE
NC score	0.046676 (rank : 6)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DCT1, O09125	Gene names	Akr1e1
Domain Architecture
Description	Aldo-keto reductase family 1 member E1 (EC 1.1.1.-).

AK1BA_HUMAN
NC score	0.044966 (rank : 7)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O60218, O75890	Gene names	AKR1B10
Domain Architecture
Description	Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (Aldose reductase-like) (ARL-1) (Small intestine reductase) (SI reductase) (Aldose reductase-related protein) (ARP) (hARP).

AK1D1_HUMAN
NC score	0.042591 (rank : 8)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P51857	Gene names	AKR1D1, SRD5B1
Domain Architecture
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

ALDR_HUMAN
NC score	0.040195 (rank : 9)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	P15121, Q9BS21, Q9UCI9	Gene names	AKR1B1, ALDR1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

K0406_MOUSE
NC score	0.030084 (rank : 10)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

IGBP1_MOUSE
NC score	0.029580 (rank : 11)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

SYNE1_HUMAN
NC score	0.020689 (rank : 12)	θ value	0.813845 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	1484	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CLIC2_HUMAN
NC score	0.018972 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O15247, O15174, Q5JT80, Q8TCE3	Gene names	CLIC2
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel protein 2 (XAP121).

RN5A_HUMAN
NC score	0.011157 (rank : 14)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	608	Shared Neighborhood Hits	3
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).