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Network neighborhood for query Sequence : GREM2_HUMAN

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GREM2_HUMAN
SwissProt Accessions	Q9H772, Q86UD9	Gene names	GREM2, CKTSF1B2, DAND3, PRDC
Domain Architecture	No domain graphic available
Description	Gremlin-2 precursor (Cysteine knot superfamily 1, BMP antagonist 2) (Protein related to DAN and cerberus).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GREM2_HUMAN
θ value	1.40038e-85 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H772, Q86UD9	Gene names	GREM2, CKTSF1B2, DAND3, PRDC
Domain Architecture	No domain graphic available
Description	Gremlin-2 precursor (Cysteine knot superfamily 1, BMP antagonist 2) (Protein related to DAN and cerberus).

GREM2_MOUSE
θ value	3.81361e-83 (rank : 2)	NC score	0.999388 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O88273	Gene names	Grem2, Cktsf1b2, Prdc
Domain Architecture	No domain graphic available
Description	Gremlin-2 precursor (Cysteine knot superfamily 1, BMP antagonist 2) (Protein related to DAN and cerberus).

GREM1_MOUSE
θ value	6.7944e-48 (rank : 3)	NC score	0.972606 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	O70326	Gene names	Grem1, Cktsf1b1, Drm
Domain Architecture	No domain graphic available
Description	Gremlin-1 precursor (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein).

GREM1_HUMAN
θ value	1.15895e-47 (rank : 4)	NC score	0.972352 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	O60565, Q52LV3, Q8N914, Q8N936	Gene names	GREM1, CKTSF1B1, DAND2, DRM, PIG2
Domain Architecture	No domain graphic available
Description	Gremlin-1 precursor (Cysteine knot superfamily 1, BMP antagonist 1) (Increased in high glucose protein 2) (IHG-2) (Down-regulated in Mos- transformed cells protein) (Proliferation-inducing gene 2 protein).

NBL1_HUMAN
θ value	1.58096e-12 (rank : 5)	NC score	0.715106 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	P41271, Q96L68	Gene names	NBL1, DAN
Domain Architecture
Description	Neuroblastoma suppressor of tumorigenicity 1 precursor (Zinc finger protein DAN) (N03).

NBL1_MOUSE
θ value	1.02475e-11 (rank : 6)	NC score	0.719782 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q61477	Gene names	Nbl1, Dan, Dana
Domain Architecture
Description	Neuroblastoma suppressor of tumorigenicity 1 precursor (Zinc finger protein DAN) (N03).

CER1_HUMAN
θ value	1.9326e-10 (rank : 7)	NC score	0.644922 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	O95813, Q6ISJ1, Q6ISJ6, Q6ISQ2, Q6ISS1	Gene names	CER1
Domain Architecture	No domain graphic available
Description	Cerberus precursor (Cerberus-related protein).

CER1_MOUSE
θ value	6.21693e-09 (rank : 8)	NC score	0.604769 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O55233, O35213	Gene names	Cer1, Cerl, Cerr1
Domain Architecture	No domain graphic available
Description	Cerberus precursor (Cerberus-related protein) (Cerberus-like protein) (Cer-l).

MUC2_HUMAN
θ value	0.00134147 (rank : 9)	NC score	0.109158 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SOST_HUMAN
θ value	0.21417 (rank : 10)	NC score	0.093116 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQB4	Gene names	SOST
Domain Architecture
Description	Sclerostin precursor.

PACN3_HUMAN
θ value	1.38821 (rank : 11)	NC score	0.030186 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	385	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NCOA2_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.036457 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

SOST_MOUSE
θ value	3.0926 (rank : 13)	NC score	0.064815 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P68, Q9D3L7	Gene names	Sost
Domain Architecture
Description	Sclerostin precursor.

NCOA2_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.032636 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

PACN3_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.024783 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	380	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NCOA1_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.025559 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

VWF_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.039273 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	381	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

Hits sorted by NC score

GREM2_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.40038e-85 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H772, Q86UD9	Gene names	GREM2, CKTSF1B2, DAND3, PRDC
Domain Architecture	No domain graphic available
Description	Gremlin-2 precursor (Cysteine knot superfamily 1, BMP antagonist 2) (Protein related to DAN and cerberus).

GREM2_MOUSE
NC score	0.999388 (rank : 2)	θ value	3.81361e-83 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O88273	Gene names	Grem2, Cktsf1b2, Prdc
Domain Architecture	No domain graphic available
Description	Gremlin-2 precursor (Cysteine knot superfamily 1, BMP antagonist 2) (Protein related to DAN and cerberus).

GREM1_MOUSE
NC score	0.972606 (rank : 3)	θ value	6.7944e-48 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	O70326	Gene names	Grem1, Cktsf1b1, Drm
Domain Architecture	No domain graphic available
Description	Gremlin-1 precursor (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein).

GREM1_HUMAN
NC score	0.972352 (rank : 4)	θ value	1.15895e-47 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	O60565, Q52LV3, Q8N914, Q8N936	Gene names	GREM1, CKTSF1B1, DAND2, DRM, PIG2
Domain Architecture	No domain graphic available
Description	Gremlin-1 precursor (Cysteine knot superfamily 1, BMP antagonist 1) (Increased in high glucose protein 2) (IHG-2) (Down-regulated in Mos- transformed cells protein) (Proliferation-inducing gene 2 protein).

NBL1_MOUSE
NC score	0.719782 (rank : 5)	θ value	1.02475e-11 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q61477	Gene names	Nbl1, Dan, Dana
Domain Architecture
Description	Neuroblastoma suppressor of tumorigenicity 1 precursor (Zinc finger protein DAN) (N03).

NBL1_HUMAN
NC score	0.715106 (rank : 6)	θ value	1.58096e-12 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	P41271, Q96L68	Gene names	NBL1, DAN
Domain Architecture
Description	Neuroblastoma suppressor of tumorigenicity 1 precursor (Zinc finger protein DAN) (N03).

CER1_HUMAN
NC score	0.644922 (rank : 7)	θ value	1.9326e-10 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	O95813, Q6ISJ1, Q6ISJ6, Q6ISQ2, Q6ISS1	Gene names	CER1
Domain Architecture	No domain graphic available
Description	Cerberus precursor (Cerberus-related protein).

CER1_MOUSE
NC score	0.604769 (rank : 8)	θ value	6.21693e-09 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O55233, O35213	Gene names	Cer1, Cerl, Cerr1
Domain Architecture	No domain graphic available
Description	Cerberus precursor (Cerberus-related protein) (Cerberus-like protein) (Cer-l).

MUC2_HUMAN
NC score	0.109158 (rank : 9)	θ value	0.00134147 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SOST_HUMAN
NC score	0.093116 (rank : 10)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQB4	Gene names	SOST
Domain Architecture
Description	Sclerostin precursor.

SOST_MOUSE
NC score	0.064815 (rank : 11)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P68, Q9D3L7	Gene names	Sost
Domain Architecture
Description	Sclerostin precursor.

VWF_MOUSE
NC score	0.039273 (rank : 12)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	381	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

NCOA2_MOUSE
NC score	0.036457 (rank : 13)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.032636 (rank : 14)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

PACN3_HUMAN
NC score	0.030186 (rank : 15)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	385	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NCOA1_HUMAN
NC score	0.025559 (rank : 16)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

PACN3_MOUSE
NC score	0.024783 (rank : 17)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	380	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.