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Network neighborhood for query Sequence : GI24_MOUSE

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GI24_MOUSE
SwissProt Accessions	Q9D659, Q6KAT9	Gene names
Domain Architecture	No domain graphic available
Description	Platelet receptor Gi24 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GI24_MOUSE
θ value	2.18449e-163 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D659, Q6KAT9	Gene names
Domain Architecture	No domain graphic available
Description	Platelet receptor Gi24 precursor.

GI24_HUMAN
θ value	1.06234e-117 (rank : 2)	NC score	0.974710 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H7M9, Q6UXF3, Q8WUG3, Q8WYZ8	Gene names	C10orf54
Domain Architecture	No domain graphic available
Description	Platelet receptor Gi24 precursor.

PDL1_MOUSE
θ value	7.1131e-05 (rank : 3)	NC score	0.211319 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_HUMAN
θ value	0.000786445 (rank : 4)	NC score	0.185850 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	195	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

BCL9_HUMAN
θ value	0.0148317 (rank : 5)	NC score	0.058069 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	1008	Shared Neighborhood Hits	3
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SHPS1_MOUSE
θ value	0.125558 (rank : 6)	NC score	0.064015 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	439	Shared Neighborhood Hits	15
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

SCN2B_HUMAN
θ value	0.163984 (rank : 7)	NC score	0.089023 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O60939, O75302, Q9UNN3	Gene names	SCN2B
Domain Architecture
Description	Sodium channel beta-2 subunit precursor.

TIMD4_MOUSE
θ value	0.163984 (rank : 8)	NC score	0.103269 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q6U7R4, Q6U7R3, Q8CIC7	Gene names	Timd4, Tim4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4) (Spleen, mucin- containing, knockout of lymphotoxin protein) (SMUCKLER).

PTPR2_HUMAN
θ value	0.365318 (rank : 9)	NC score	0.022428 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

BT2A2_HUMAN
θ value	0.62314 (rank : 10)	NC score	0.043534 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	191	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

TIMD3_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.123694 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDQ0, Q8WW60, Q96K94	Gene names	HAVCR2, TIM3, TIMD3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

BT2A3_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.039898 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

ICOSL_MOUSE
θ value	1.06291 (rank : 13)	NC score	0.085277 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

MACF4_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.014013 (rank : 37)
Query Neighborhood Hits	34	Target Neighborhood Hits	1321	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

SHPS1_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.055863 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SCN3B_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.059412 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NY72, Q9ULR2	Gene names	SCN3B, KIAA1158
Domain Architecture
Description	Sodium channel beta-3 subunit precursor.

SCN3B_MOUSE
θ value	2.36792 (rank : 17)	NC score	0.060907 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHK2, Q91Z99	Gene names	Scn3b
Domain Architecture
Description	Sodium channel beta-3 subunit precursor.

TIMD1_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.125107 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

VSIG2_HUMAN
θ value	2.36792 (rank : 19)	NC score	0.038199 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	321	Shared Neighborhood Hits	13
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

SIRB1_HUMAN
θ value	3.0926 (rank : 20)	NC score	0.049152 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	422	Shared Neighborhood Hits	9
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

TIMD2_MOUSE
θ value	3.0926 (rank : 21)	NC score	0.082270 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

HPLN4_MOUSE
θ value	4.03905 (rank : 22)	NC score	0.019947 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

TREM2_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.036846 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

FPRP_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.031749 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	116	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

KV2A_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.008555 (rank : 39)
Query Neighborhood Hits	34	Target Neighborhood Hits	240	Shared Neighborhood Hits	8
SwissProt Accessions	P01614	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-II region Cum.

BMP3B_HUMAN
θ value	6.88961 (rank : 26)	NC score	0.009793 (rank : 38)
Query Neighborhood Hits	34	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	P55107, Q9UCX6	Gene names	GDF10, BMP3B
Domain Architecture
Description	Bone morphogenetic protein 3b precursor (BMP-3b) (Growth/differentiation factor 10) (GDF-10) (Bone-inducing protein) (BIP).

CM35A_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.041112 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	65	Shared Neighborhood Hits	15
SwissProt Accessions	Q08708	Gene names	CD300C, CMRF35, CMRF35A
Domain Architecture
Description	CMRF35-A antigen precursor (CMRF-35) (CD300c antigen).

PDL2_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.089922 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

TIMD4_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.077473 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	Q96H15	Gene names	TIMD4, TIM4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4).

FMN2_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.014774 (rank : 36)
Query Neighborhood Hits	34	Target Neighborhood Hits	484	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

LV1D_MOUSE
θ value	8.99809 (rank : 31)	NC score	0.005091 (rank : 41)
Query Neighborhood Hits	34	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	P01726	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda-1 chain V region H2020 precursor.

RHG07_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.007954 (rank : 40)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

SCN2B_MOUSE
θ value	8.99809 (rank : 33)	NC score	0.079752 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q56A07	Gene names	Scn2b
Domain Architecture	No domain graphic available
Description	Sodium channel beta-2 subunit precursor.

VSIG2_MOUSE
θ value	8.99809 (rank : 34)	NC score	0.031447 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	316	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CD276_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.051726 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	261	Shared Neighborhood Hits	13
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

CD276_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.055413 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	243	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD80_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.052182 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	136	Shared Neighborhood Hits	10
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

ICOSL_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.060599 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

PDL2_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.073027 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

TIMD1_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.060113 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

TIMD3_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.083869 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VIM0	Gene names	Havcr2, Tim3, Timd3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 homolog precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

Hits sorted by NC score

GI24_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.18449e-163 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D659, Q6KAT9	Gene names
Domain Architecture	No domain graphic available
Description	Platelet receptor Gi24 precursor.

GI24_HUMAN
NC score	0.974710 (rank : 2)	θ value	1.06234e-117 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H7M9, Q6UXF3, Q8WUG3, Q8WYZ8	Gene names	C10orf54
Domain Architecture	No domain graphic available
Description	Platelet receptor Gi24 precursor.

PDL1_MOUSE
NC score	0.211319 (rank : 3)	θ value	7.1131e-05 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_HUMAN
NC score	0.185850 (rank : 4)	θ value	0.000786445 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	195	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

TIMD1_MOUSE
NC score	0.125107 (rank : 5)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

TIMD3_HUMAN
NC score	0.123694 (rank : 6)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDQ0, Q8WW60, Q96K94	Gene names	HAVCR2, TIM3, TIMD3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

TIMD4_MOUSE
NC score	0.103269 (rank : 7)	θ value	0.163984 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q6U7R4, Q6U7R3, Q8CIC7	Gene names	Timd4, Tim4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4) (Spleen, mucin- containing, knockout of lymphotoxin protein) (SMUCKLER).

PDL2_HUMAN
NC score	0.089922 (rank : 8)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

SCN2B_HUMAN
NC score	0.089023 (rank : 9)	θ value	0.163984 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O60939, O75302, Q9UNN3	Gene names	SCN2B
Domain Architecture
Description	Sodium channel beta-2 subunit precursor.

ICOSL_MOUSE
NC score	0.085277 (rank : 10)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

TIMD3_MOUSE
NC score	0.083869 (rank : 11)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	34	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VIM0	Gene names	Havcr2, Tim3, Timd3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 homolog precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

TIMD2_MOUSE
NC score	0.082270 (rank : 12)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

SCN2B_MOUSE
NC score	0.079752 (rank : 13)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q56A07	Gene names	Scn2b
Domain Architecture	No domain graphic available
Description	Sodium channel beta-2 subunit precursor.

TIMD4_HUMAN
NC score	0.077473 (rank : 14)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	Q96H15	Gene names	TIMD4, TIM4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4).

PDL2_MOUSE
NC score	0.073027 (rank : 15)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	34	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

SHPS1_MOUSE
NC score	0.064015 (rank : 16)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	439	Shared Neighborhood Hits	15
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

SCN3B_MOUSE
NC score	0.060907 (rank : 17)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHK2, Q91Z99	Gene names	Scn3b
Domain Architecture
Description	Sodium channel beta-3 subunit precursor.

ICOSL_HUMAN
NC score	0.060599 (rank : 18)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	34	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

TIMD1_HUMAN
NC score	0.060113 (rank : 19)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	34	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

SCN3B_HUMAN
NC score	0.059412 (rank : 20)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NY72, Q9ULR2	Gene names	SCN3B, KIAA1158
Domain Architecture
Description	Sodium channel beta-3 subunit precursor.

BCL9_HUMAN
NC score	0.058069 (rank : 21)	θ value	0.0148317 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	1008	Shared Neighborhood Hits	3
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SHPS1_HUMAN
NC score	0.055863 (rank : 22)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

CD276_MOUSE
NC score	0.055413 (rank : 23)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	34	Target Neighborhood Hits	243	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD80_MOUSE
NC score	0.052182 (rank : 24)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	34	Target Neighborhood Hits	136	Shared Neighborhood Hits	10
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CD276_HUMAN
NC score	0.051726 (rank : 25)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	261	Shared Neighborhood Hits	13
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

SIRB1_HUMAN
NC score	0.049152 (rank : 26)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	422	Shared Neighborhood Hits	9
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

BT2A2_HUMAN
NC score	0.043534 (rank : 27)	θ value	0.62314 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	191	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

CM35A_HUMAN
NC score	0.041112 (rank : 28)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	65	Shared Neighborhood Hits	15
SwissProt Accessions	Q08708	Gene names	CD300C, CMRF35, CMRF35A
Domain Architecture
Description	CMRF35-A antigen precursor (CMRF-35) (CD300c antigen).

BT2A3_HUMAN
NC score	0.039898 (rank : 29)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

VSIG2_HUMAN
NC score	0.038199 (rank : 30)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	321	Shared Neighborhood Hits	13
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

TREM2_HUMAN
NC score	0.036846 (rank : 31)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

FPRP_MOUSE
NC score	0.031749 (rank : 32)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	116	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

VSIG2_MOUSE
NC score	0.031447 (rank : 33)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	316	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

PTPR2_HUMAN
NC score	0.022428 (rank : 34)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

HPLN4_MOUSE
NC score	0.019947 (rank : 35)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

FMN2_HUMAN
NC score	0.014774 (rank : 36)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	484	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

MACF4_HUMAN
NC score	0.014013 (rank : 37)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	1321	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

BMP3B_HUMAN
NC score	0.009793 (rank : 38)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	P55107, Q9UCX6	Gene names	GDF10, BMP3B
Domain Architecture
Description	Bone morphogenetic protein 3b precursor (BMP-3b) (Growth/differentiation factor 10) (GDF-10) (Bone-inducing protein) (BIP).

KV2A_HUMAN
NC score	0.008555 (rank : 39)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	240	Shared Neighborhood Hits	8
SwissProt Accessions	P01614	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-II region Cum.

RHG07_MOUSE
NC score	0.007954 (rank : 40)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

LV1D_MOUSE
NC score	0.005091 (rank : 41)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	P01726	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda-1 chain V region H2020 precursor.