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Network neighborhood for query Sequence : F262_HUMAN

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F262_HUMAN
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

F261_HUMAN
θ value	0 (rank : 1)	NC score	0.991632 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
θ value	0 (rank : 3)	NC score	0.999054 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F263_HUMAN
θ value	0 (rank : 4)	NC score	0.991669 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

F264_HUMAN
θ value	0 (rank : 5)	NC score	0.990773 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

CN37_HUMAN
θ value	0.0431538 (rank : 6)	NC score	0.112620 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P09543	Gene names	CNP
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

PGAM2_HUMAN
θ value	0.21417 (rank : 7)	NC score	0.084622 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

CN37_MOUSE
θ value	0.279714 (rank : 8)	NC score	0.095213 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P16330, Q61424, Q8C7C9, Q91V42, Q923F3	Gene names	Cnp, Cnp1
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

PGAM2_MOUSE
θ value	0.62314 (rank : 9)	NC score	0.086679 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

ARF6_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.022452 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P62330, P26438	Gene names	ARF6
Domain Architecture
Description	ADP-ribosylation factor 6.

ARF6_MOUSE
θ value	0.813845 (rank : 11)	NC score	0.022452 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P62331, P26438	Gene names	Arf6
Domain Architecture
Description	ADP-ribosylation factor 6.

EXOC2_HUMAN
θ value	0.813845 (rank : 12)	NC score	0.038615 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KP1, Q5JPC8, Q96AN6, Q9NUZ8, Q9UJM7	Gene names	EXOC2, SEC5, SEC5L1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

PGAM1_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.087690 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
θ value	1.38821 (rank : 14)	NC score	0.087670 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

XAB1_MOUSE
θ value	1.38821 (rank : 15)	NC score	0.032813 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCE2	Gene names	Xab1, Mbdin
Domain Architecture
Description	XPA-binding protein 1.

YLPM1_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.028562 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	670	Shared Neighborhood Hits	6
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

YLPM1_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.028962 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	505	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SEM6A_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.006817 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

LNK_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.008877 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	132	Shared Neighborhood Hits	2
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ORCT4_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.011172 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y267, Q6DJT3	Gene names	SLC22A14, ORCTL4
Domain Architecture	No domain graphic available
Description	Organic-cation transporter-like 4 (Solute carrier family 22 member 14).

EPIPL_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.006851 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

SEM6A_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.006044 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).

PGAM4_HUMAN
θ value	θ > 10 (rank : 23)	NC score	0.055276 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

Hits sorted by NC score

F262_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
NC score	0.999054 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F263_HUMAN
NC score	0.991669 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

F261_HUMAN
NC score	0.991632 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F264_HUMAN
NC score	0.990773 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

CN37_HUMAN
NC score	0.112620 (rank : 6)	θ value	0.0431538 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P09543	Gene names	CNP
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

CN37_MOUSE
NC score	0.095213 (rank : 7)	θ value	0.279714 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P16330, Q61424, Q8C7C9, Q91V42, Q923F3	Gene names	Cnp, Cnp1
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

PGAM1_HUMAN
NC score	0.087690 (rank : 8)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
NC score	0.087670 (rank : 9)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM2_MOUSE
NC score	0.086679 (rank : 10)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_HUMAN
NC score	0.084622 (rank : 11)	θ value	0.21417 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM4_HUMAN
NC score	0.055276 (rank : 12)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

EXOC2_HUMAN
NC score	0.038615 (rank : 13)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KP1, Q5JPC8, Q96AN6, Q9NUZ8, Q9UJM7	Gene names	EXOC2, SEC5, SEC5L1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

XAB1_MOUSE
NC score	0.032813 (rank : 14)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCE2	Gene names	Xab1, Mbdin
Domain Architecture
Description	XPA-binding protein 1.

YLPM1_MOUSE
NC score	0.028962 (rank : 15)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	505	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

YLPM1_HUMAN
NC score	0.028562 (rank : 16)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	670	Shared Neighborhood Hits	6
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ARF6_HUMAN
NC score	0.022452 (rank : 17)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P62330, P26438	Gene names	ARF6
Domain Architecture
Description	ADP-ribosylation factor 6.

ARF6_MOUSE
NC score	0.022452 (rank : 18)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P62331, P26438	Gene names	Arf6
Domain Architecture
Description	ADP-ribosylation factor 6.

ORCT4_HUMAN
NC score	0.011172 (rank : 19)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y267, Q6DJT3	Gene names	SLC22A14, ORCTL4
Domain Architecture	No domain graphic available
Description	Organic-cation transporter-like 4 (Solute carrier family 22 member 14).

LNK_MOUSE
NC score	0.008877 (rank : 20)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	132	Shared Neighborhood Hits	2
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

EPIPL_HUMAN
NC score	0.006851 (rank : 21)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

SEM6A_HUMAN
NC score	0.006817 (rank : 22)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

SEM6A_MOUSE
NC score	0.006044 (rank : 23)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).