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Network neighborhood for query Sequence : ERG7_HUMAN

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ERG7_HUMAN
SwissProt Accessions	P48449, Q8IYL6, Q9UEZ1	Gene names	LSS, OSC
Domain Architecture
Description	Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ERG7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	5	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	P48449, Q8IYL6, Q9UEZ1	Gene names	LSS, OSC
Domain Architecture
Description	Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC).

ERG7_MOUSE
θ value	0 (rank : 2)	NC score	0.998269 (rank : 2)
Query Neighborhood Hits	5	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLN5, Q8BVJ4, Q8K307	Gene names	Lss
Domain Architecture	No domain graphic available
Description	Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC).

CP2J6_MOUSE
θ value	1.38821 (rank : 3)	NC score	0.009386 (rank : 5)
Query Neighborhood Hits	5	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	O54750	Gene names	Cyp2j6
Domain Architecture
Description	Cytochrome P450 2J6 (EC 1.14.14.1) (CYPIIJ6) (Arachidonic acid epoxygenase).

PGTB_HUMAN
θ value	1.38821 (rank : 4)	NC score	0.033381 (rank : 3)
Query Neighborhood Hits	5	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P53611, Q92697	Gene names	RABGGTB, GGTB
Domain Architecture
Description	Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (Rab geranylgeranyltransferase subunit beta) (Rab geranyl- geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta).

OPTN_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.014026 (rank : 4)
Query Neighborhood Hits	5	Target Neighborhood Hits	827	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

Hits sorted by NC score

ERG7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	5	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	P48449, Q8IYL6, Q9UEZ1	Gene names	LSS, OSC
Domain Architecture
Description	Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC).

ERG7_MOUSE
NC score	0.998269 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	5	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLN5, Q8BVJ4, Q8K307	Gene names	Lss
Domain Architecture	No domain graphic available
Description	Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC).

PGTB_HUMAN
NC score	0.033381 (rank : 3)	θ value	1.38821 (rank : 4)
Query Neighborhood Hits	5	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P53611, Q92697	Gene names	RABGGTB, GGTB
Domain Architecture
Description	Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (Rab geranylgeranyltransferase subunit beta) (Rab geranyl- geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta).

OPTN_HUMAN
NC score	0.014026 (rank : 4)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	5	Target Neighborhood Hits	827	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

CP2J6_MOUSE
NC score	0.009386 (rank : 5)	θ value	1.38821 (rank : 3)
Query Neighborhood Hits	5	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	O54750	Gene names	Cyp2j6
Domain Architecture
Description	Cytochrome P450 2J6 (EC 1.14.14.1) (CYPIIJ6) (Arachidonic acid epoxygenase).