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Network neighborhood for query Sequence : ACSL4_HUMAN

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ACSL4_HUMAN
SwissProt Accessions	O60488, O60848, O60849	Gene names	ACSL4, ACS4, FACL4, LACS4
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ACSL3_HUMAN
θ value	0 (rank : 1)	NC score	0.995601 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	O95573, Q60I92, Q8IUM9	Gene names	ACSL3, ACS3, FACL3, LACS3
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3).

ACSL3_MOUSE
θ value	0 (rank : 2)	NC score	0.995189 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CZW4	Gene names	Acsl3, Acs3, Facl3
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3).

ACSL4_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	O60488, O60848, O60849	Gene names	ACSL4, ACS4, FACL4, LACS4
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4).

ACSL4_MOUSE
θ value	0 (rank : 4)	NC score	0.999048 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUJ7, Q9JHT4, Q9R0H3	Gene names	Acsl4, Acs4, Facl4
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4) (mACS4).

ACSL5_HUMAN
θ value	1.07224e-85 (rank : 5)	NC score	0.916573 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ULC5, Q6UX44, Q9UIU4	Gene names	ACSL5, ACS5, FACL5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

ACSL1_HUMAN
θ value	2.02215e-84 (rank : 6)	NC score	0.913608 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P33121, P41215, Q8N8V7, Q8TA99	Gene names	ACSL1, FACL1, FACL2, LACS, LACS1, LACS2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2).

ACSL1_MOUSE
θ value	2.02215e-84 (rank : 7)	NC score	0.915985 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P41216, Q9DBK5	Gene names	Acsl1, Acsl2, Facl2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1).

ACSL6_HUMAN
θ value	6.50502e-83 (rank : 8)	NC score	0.910693 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKU0, O94924, O95829	Gene names	ACSL6, ACS2, FACL6, KIAA0837, LACS5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

ACSL6_MOUSE
θ value	1.2268e-81 (rank : 9)	NC score	0.911599 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WC3, Q80ZF1	Gene names	Acsl6, Facl6
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

ACSL5_MOUSE
θ value	6.08852e-81 (rank : 10)	NC score	0.913771 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8JZR0	Gene names	Acsl5, Facl5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

S27A2_MOUSE
θ value	9.29e-05 (rank : 11)	NC score	0.183455 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	O35488, O70550, O88560	Gene names	Slc27a2, Acsvl1, Facvl1, Fatp2, Vlacs, Vlcs
Domain Architecture
Description	Very-long-chain acyl-CoA synthetase (EC 6.2.1.-) (VLCS) (Very-long- chain-fatty-acid-CoA ligase) (VLACS) (THCA-CoA ligase) (Fatty-acid- coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Fatty acid transport protein 2) (FATP-2) (Solute carrier family 27 member 2).

S27A2_HUMAN
θ value	0.000270298 (rank : 12)	NC score	0.200785 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	O14975	Gene names	SLC27A2, ACSVL1, FACVL1, FATP2, VLACS
Domain Architecture
Description	Very-long-chain acyl-CoA synthetase (EC 6.2.1.-) (VLCS) (Very-long- chain-fatty-acid-CoA ligase) (VLACS) (THCA-CoA ligase) (Fatty-acid- coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Fatty acid transport protein 2) (FATP-2) (Solute carrier family 27 member 2).

ACS2L_HUMAN
θ value	0.00509761 (rank : 13)	NC score	0.171299 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NUB1, Q5TF42, Q8IV99, Q8N234, Q96JI1, Q96JX6, Q9NU28	Gene names	ACSS1, ACAS2L, KIAA1846
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (Acyl- CoA synthetase short-chain family member 1).

S27A5_HUMAN
θ value	0.00509761 (rank : 14)	NC score	0.227273 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2P5	Gene names	SLC27A5, ACSB, ACSVL6, FACVL3, FATP5
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long-chain acyl-CoA synthetase homolog 2) (VLCSH2) (VLCS-H2) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty-acid- coenzyme A ligase, very long-chain 3) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

S27A4_MOUSE
θ value	0.00665767 (rank : 15)	NC score	0.202450 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q91VE0, O88562	Gene names	Slc27a4, Acsvl4, Fatp4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

ACSA_HUMAN
θ value	0.0193708 (rank : 16)	NC score	0.152194 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NR19, Q5QPH2, Q96EL0, Q9NQP7, Q9UJ15	Gene names	ACSS2, ACAS2
Domain Architecture
Description	Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2).

S27A3_HUMAN
θ value	0.0193708 (rank : 17)	NC score	0.201103 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q5K4L6, Q5VUQ7, Q5VUQ8, Q6ZV16, Q8N2X7, Q96SW5, Q9BTJ5, Q9BTY5	Gene names	SLC27A3, ACSVL3, FATP3
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 3 (EC 6.2.1.-) (Fatty acid transport protein 3) (FATP-3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (Solute carrier family 27 member 3).

S27A3_MOUSE
θ value	0.0193708 (rank : 18)	NC score	0.202083 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	O88561, Q6PAU1, Q8BK70	Gene names	Slc27a3, Acsvl3, Fatp3
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 3 (EC 6.2.1.-) (Fatty acid transport protein 3) (FATP-3) (Solute carrier family 27 member 3).

S27A4_HUMAN
θ value	0.0193708 (rank : 19)	NC score	0.176556 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P1M0, O95186	Gene names	SLC27A4, ACSVL4, FATP4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

ACSA_MOUSE
θ value	0.0431538 (rank : 20)	NC score	0.144841 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXG4	Gene names	Acss2, Acas2, Acecs1
Domain Architecture
Description	Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2).

S27A5_MOUSE
θ value	0.0431538 (rank : 21)	NC score	0.216113 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q4LDG0, O88694, Q91VD5	Gene names	Slc27a5, Acsb, Acsvl6, Fatp5, Vlacsr
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

S27A1_HUMAN
θ value	0.0961366 (rank : 22)	NC score	0.161331 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PCB7	Gene names	SLC27A1, ACSVL5, FATP1
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 1 (EC 6.2.1.-) (Fatty acid transport protein 1) (FATP-1) (Solute carrier family 27 member 1).

ACS2L_MOUSE
θ value	0.163984 (rank : 23)	NC score	0.165807 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q99NB1, Q8K0M6	Gene names	Acss1, Acas2, Acas2l
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1).

TCF20_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.024058 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	323	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

CI123_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.051836 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GE9, Q5T6Y9, Q9NT74	Gene names	C9orf123
Domain Architecture	No domain graphic available
Description	Protein C9orf123.

MRP2_MOUSE
θ value	2.36792 (rank : 26)	NC score	0.005073 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	113	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VI47	Gene names	Abcc2
Domain Architecture
Description	Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2).

ADA17_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.005528 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

HNF6_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.006839 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	127	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBC0, Q99744, Q9UMR6	Gene names	ONECUT1, HNF6, HNF6A
Domain Architecture
Description	Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1).

LEG4_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.006002 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K419, O88353, Q91X74	Gene names	Lgals4
Domain Architecture
Description	Galectin-4 (Lactose-binding lectin 4).

TRA2B_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.005490 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	P62995, O15449, Q15815, Q64283	Gene names	SFRS10, TRA2B
Domain Architecture	No domain graphic available
Description	Arginine/serine-rich-splicing factor 10 (Transformer-2-beta) (HTRA2- beta) (Transformer 2 protein homolog).

TRA2B_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.005490 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	P62996, O15449, Q15815, Q64283	Gene names	Sfrs10, Silg41, Tra2b
Domain Architecture	No domain graphic available
Description	Arginine/serine-rich-splicing factor 10 (Transformer-2-beta) (HTRA2- beta) (Transformer 2 protein homolog) (Silica-induced gene 41 protein) (SIG-41).

S27A1_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.140133 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	Q60714	Gene names	Slc27a1, Fatp, Fatp1
Domain Architecture
Description	Long-chain fatty acid transport protein 1 (EC 6.2.1.-) (Fatty acid transport protein 1) (FATP-1) (Solute carrier family 27 member 1).

S27A6_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.131110 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2P4, Q6IAM5, Q7Z6E6, Q86YF6	Gene names	SLC27A6, ACSVL2, FACVL2, FATP1
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 6 (Fatty acid transport protein 6) (FATP-6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Solute carrier family 27 member 6).

Hits sorted by NC score

ACSL4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	O60488, O60848, O60849	Gene names	ACSL4, ACS4, FACL4, LACS4
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4).

ACSL4_MOUSE
NC score	0.999048 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUJ7, Q9JHT4, Q9R0H3	Gene names	Acsl4, Acs4, Facl4
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4) (mACS4).

ACSL3_HUMAN
NC score	0.995601 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	O95573, Q60I92, Q8IUM9	Gene names	ACSL3, ACS3, FACL3, LACS3
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3).

ACSL3_MOUSE
NC score	0.995189 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CZW4	Gene names	Acsl3, Acs3, Facl3
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3).

ACSL5_HUMAN
NC score	0.916573 (rank : 5)	θ value	1.07224e-85 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ULC5, Q6UX44, Q9UIU4	Gene names	ACSL5, ACS5, FACL5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

ACSL1_MOUSE
NC score	0.915985 (rank : 6)	θ value	2.02215e-84 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P41216, Q9DBK5	Gene names	Acsl1, Acsl2, Facl2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1).

ACSL5_MOUSE
NC score	0.913771 (rank : 7)	θ value	6.08852e-81 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8JZR0	Gene names	Acsl5, Facl5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

ACSL1_HUMAN
NC score	0.913608 (rank : 8)	θ value	2.02215e-84 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P33121, P41215, Q8N8V7, Q8TA99	Gene names	ACSL1, FACL1, FACL2, LACS, LACS1, LACS2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2).

ACSL6_MOUSE
NC score	0.911599 (rank : 9)	θ value	1.2268e-81 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WC3, Q80ZF1	Gene names	Acsl6, Facl6
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

ACSL6_HUMAN
NC score	0.910693 (rank : 10)	θ value	6.50502e-83 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKU0, O94924, O95829	Gene names	ACSL6, ACS2, FACL6, KIAA0837, LACS5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

S27A5_HUMAN
NC score	0.227273 (rank : 11)	θ value	0.00509761 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2P5	Gene names	SLC27A5, ACSB, ACSVL6, FACVL3, FATP5
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long-chain acyl-CoA synthetase homolog 2) (VLCSH2) (VLCS-H2) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty-acid- coenzyme A ligase, very long-chain 3) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

S27A5_MOUSE
NC score	0.216113 (rank : 12)	θ value	0.0431538 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q4LDG0, O88694, Q91VD5	Gene names	Slc27a5, Acsb, Acsvl6, Fatp5, Vlacsr
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

S27A4_MOUSE
NC score	0.202450 (rank : 13)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q91VE0, O88562	Gene names	Slc27a4, Acsvl4, Fatp4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

S27A3_MOUSE
NC score	0.202083 (rank : 14)	θ value	0.0193708 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	O88561, Q6PAU1, Q8BK70	Gene names	Slc27a3, Acsvl3, Fatp3
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 3 (EC 6.2.1.-) (Fatty acid transport protein 3) (FATP-3) (Solute carrier family 27 member 3).

S27A3_HUMAN
NC score	0.201103 (rank : 15)	θ value	0.0193708 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q5K4L6, Q5VUQ7, Q5VUQ8, Q6ZV16, Q8N2X7, Q96SW5, Q9BTJ5, Q9BTY5	Gene names	SLC27A3, ACSVL3, FATP3
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 3 (EC 6.2.1.-) (Fatty acid transport protein 3) (FATP-3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (Solute carrier family 27 member 3).

S27A2_HUMAN
NC score	0.200785 (rank : 16)	θ value	0.000270298 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	O14975	Gene names	SLC27A2, ACSVL1, FACVL1, FATP2, VLACS
Domain Architecture
Description	Very-long-chain acyl-CoA synthetase (EC 6.2.1.-) (VLCS) (Very-long- chain-fatty-acid-CoA ligase) (VLACS) (THCA-CoA ligase) (Fatty-acid- coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Fatty acid transport protein 2) (FATP-2) (Solute carrier family 27 member 2).

S27A2_MOUSE
NC score	0.183455 (rank : 17)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	O35488, O70550, O88560	Gene names	Slc27a2, Acsvl1, Facvl1, Fatp2, Vlacs, Vlcs
Domain Architecture
Description	Very-long-chain acyl-CoA synthetase (EC 6.2.1.-) (VLCS) (Very-long- chain-fatty-acid-CoA ligase) (VLACS) (THCA-CoA ligase) (Fatty-acid- coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Fatty acid transport protein 2) (FATP-2) (Solute carrier family 27 member 2).

S27A4_HUMAN
NC score	0.176556 (rank : 18)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P1M0, O95186	Gene names	SLC27A4, ACSVL4, FATP4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

ACS2L_HUMAN
NC score	0.171299 (rank : 19)	θ value	0.00509761 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NUB1, Q5TF42, Q8IV99, Q8N234, Q96JI1, Q96JX6, Q9NU28	Gene names	ACSS1, ACAS2L, KIAA1846
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (Acyl- CoA synthetase short-chain family member 1).

ACS2L_MOUSE
NC score	0.165807 (rank : 20)	θ value	0.163984 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q99NB1, Q8K0M6	Gene names	Acss1, Acas2, Acas2l
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1).

S27A1_HUMAN
NC score	0.161331 (rank : 21)	θ value	0.0961366 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PCB7	Gene names	SLC27A1, ACSVL5, FATP1
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 1 (EC 6.2.1.-) (Fatty acid transport protein 1) (FATP-1) (Solute carrier family 27 member 1).

ACSA_HUMAN
NC score	0.152194 (rank : 22)	θ value	0.0193708 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NR19, Q5QPH2, Q96EL0, Q9NQP7, Q9UJ15	Gene names	ACSS2, ACAS2
Domain Architecture
Description	Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2).

ACSA_MOUSE
NC score	0.144841 (rank : 23)	θ value	0.0431538 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXG4	Gene names	Acss2, Acas2, Acecs1
Domain Architecture
Description	Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2).

S27A1_MOUSE
NC score	0.140133 (rank : 24)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	Q60714	Gene names	Slc27a1, Fatp, Fatp1
Domain Architecture
Description	Long-chain fatty acid transport protein 1 (EC 6.2.1.-) (Fatty acid transport protein 1) (FATP-1) (Solute carrier family 27 member 1).

S27A6_HUMAN
NC score	0.131110 (rank : 25)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2P4, Q6IAM5, Q7Z6E6, Q86YF6	Gene names	SLC27A6, ACSVL2, FACVL2, FATP1
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 6 (Fatty acid transport protein 6) (FATP-6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Solute carrier family 27 member 6).

CI123_HUMAN
NC score	0.051836 (rank : 26)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GE9, Q5T6Y9, Q9NT74	Gene names	C9orf123
Domain Architecture	No domain graphic available
Description	Protein C9orf123.

TCF20_HUMAN
NC score	0.024058 (rank : 27)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	323	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

HNF6_HUMAN
NC score	0.006839 (rank : 28)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	127	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBC0, Q99744, Q9UMR6	Gene names	ONECUT1, HNF6, HNF6A
Domain Architecture
Description	Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1).

LEG4_MOUSE
NC score	0.006002 (rank : 29)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K419, O88353, Q91X74	Gene names	Lgals4
Domain Architecture
Description	Galectin-4 (Lactose-binding lectin 4).

ADA17_MOUSE
NC score	0.005528 (rank : 30)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

TRA2B_HUMAN
NC score	0.005490 (rank : 31)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	P62995, O15449, Q15815, Q64283	Gene names	SFRS10, TRA2B
Domain Architecture	No domain graphic available
Description	Arginine/serine-rich-splicing factor 10 (Transformer-2-beta) (HTRA2- beta) (Transformer 2 protein homolog).

TRA2B_MOUSE
NC score	0.005490 (rank : 32)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	P62996, O15449, Q15815, Q64283	Gene names	Sfrs10, Silg41, Tra2b
Domain Architecture	No domain graphic available
Description	Arginine/serine-rich-splicing factor 10 (Transformer-2-beta) (HTRA2- beta) (Transformer 2 protein homolog) (Silica-induced gene 41 protein) (SIG-41).

MRP2_MOUSE
NC score	0.005073 (rank : 33)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	113	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VI47	Gene names	Abcc2
Domain Architecture
Description	Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2).